Organic Peroxides in Transition-Metal-Free Cyclization and Coupling Reactions (C–C) via Oxidative Transformation DOI Creative Commons
Amin Rezaeifard, Fatemeh Doraghi, Fatemeh Akbari

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Transition-metal-free transformations are recognized as green and sustainable methods for constructing carbon-carbon bonds in organic synthesis. This review describes the application of six peroxides, including tert-butyl hydroperoxide (TBHP), di-tert-butyl peroxide (DTBP), peroxybenzoate (TBPB), benzoyl (BPO), dialauroyl (DLP), diguyl (DCP), C-C bond construction, highlighting selected examples mechanisms challenging transformations. Each section concludes with a detailed overview suitable reagents various coupling reactions strengths weaknesses reported works. work aims to inspire further innovations transition-metal-free oxidative transformations, promoting eco-friendly chemical processes paving way new peroxide-based synthesis methods.

Language: Английский

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways DOI Creative Commons
Zhu Liang,

Yanchi Bi,

Ting Liang

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 5, 2025

Osteoarthritis (OA) is considered an advancing chronic degenerative joint disease, leading to severe physical functional impairment of patients. Its development closely related increased inflammation and oxidative stress within the joint. Ginkgetin (GK), a natural non-toxic chemical, has proven anti-inflammatory, antioxidant, anti-tumor, neuroprotective effects. First, this study utilizes network pharmacology explore intrinsic connection between GK OA. In vitro, SW1353 human cartilage cells were stimulated with Tert-butyl hydrogen peroxide (TBHP), different concentrations pre-treated evaluate its protective GK's anti-inflammatory antioxidative effects comprehensively assessed via MTT assay, western blot, cell immunofluorescence, ELISA, transcriptome sequencing. Potential underlying mechanisms also explored. vivo, OA was induced in rats anterior cruciate ligament transection (ACLT), impact on protection further histological analysis blot. Network revealed that regulates several key pathways, especially NF-κB, HIF-1, PI3K-AKT, substances like reactive oxygen species. vitro experiments showed effectively reverses damage from TBHP, inhibits inflammatory factor release, protects Extracellular matrix (ECM) degradation. These functions may be achieved NF-κB MAPK signaling pathways. vivo significantly reduced proteoglycan loss ACLT inhibited metalloproteinase 13 (MMP13) ADAMTS5 (A disintegrin thrombospondin motifs 5) production, preventing degeneration rats. findings suggest potential as therapeutic agent for OA, offering new strategies directions treatment.

Language: Английский

Citations

1
CuI-Catalyzed Dearomatization/Peroxidation/Cyclization Cascade of Pyrrole-Tethered Indoles DOI

Xue Sheng,

Yang Liu,

Jiayi Han

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

A mild CuI-catalyzed dearomatization/peroxidation/cyclization cascade of pyrrole-tethered indoles has been reached, providing peroxide-incorporated indolizino[8,7-b]indole derivatives in acceptable to good yields (46–76%). Dehydrogenated peroxide can be obtained by the use a FeCl3/TBHP (tBuOOH)/2,2,2-trifluoroethanol (TFE) system at 50 °C.

Language: Английский

Citations

0
Role of tert-Butyl Hydroperoxide (TBHP) in Cross-Coupling Reactions DOI Creative Commons
Ravi Varala,

Murali Mohan Achari Kamsali,

Durga Prasad Beda

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

tert-Butyl hydroperoxide (tBuOOH, TBHP) is a common used in variety of oxidation processes. The primary reasons for TBHP’s increased usability are its low cost, environmental friendliness, high efficiency, and capacity to replace dangerous or scarce heavy metal oxidants. In this book chapter, we have reviewed briefed up representative applications TBHP cross-coupling reactions from 2014 the present.

Language: Английский

Citations

0
Organic Peroxides in Transition-Metal-Free Cyclization and Coupling Reactions (C–C) via Oxidative Transformation DOI Creative Commons
Amin Rezaeifard, Fatemeh Doraghi, Fatemeh Akbari

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Transition-metal-free transformations are recognized as green and sustainable methods for constructing carbon-carbon bonds in organic synthesis. This review describes the application of six peroxides, including tert-butyl hydroperoxide (TBHP), di-tert-butyl peroxide (DTBP), peroxybenzoate (TBPB), benzoyl (BPO), dialauroyl (DLP), diguyl (DCP), C-C bond construction, highlighting selected examples mechanisms challenging transformations. Each section concludes with a detailed overview suitable reagents various coupling reactions strengths weaknesses reported works. work aims to inspire further innovations transition-metal-free oxidative transformations, promoting eco-friendly chemical processes paving way new peroxide-based synthesis methods.

Language: Английский

Citations

0