Vinylation of Alcohols, Thiols, and Nitrogen Compounds Using a Stoichiometric Amount of In Situ Generated Acetylene

Organics, Journal Year: 2025, Volume and Issue: 6(1), P. 5 - 5

Published: Feb. 8, 2025

In this work, we developed a highly efficient and versatile environmentally benign methodology for the vinylation of broad scope substances, including alcohols, thiols, nitrogen compounds. The key advantage proposed method is use calcium carbide as robust acetylene source in stoichiometric ratio to substrates. Lacking requirement excess, protocol safe, economic, limits waste production. procedure allows large variety O-,S-,N-vinyl compounds be synthesized up quantitative yields. Our scalable, allowing us obtain vinyl derivatives Gram-scale quantities. We also demonstrated significant synthetic value our approach by performing label-economic synthesis 13C2-labeled using carbide-13C2. well-optimized process, conversion Ca13C2 reached 89%.

Language: Английский

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Synthesis of 3-Chloro-6-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)pyridazine and Its Deuterated Analogue

Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(11), P. 2833 - 2840

Published: Nov. 1, 2024

Language: Английский

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Base-Free Fluoride-Mediated Vinylation of Alcohols with Calcium Carbide

Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3155 - 3163

Published: Dec. 1, 2024

Language: Английский

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