Multi-pronged approaches to the mechanism-based inactivation of aldose reductase by natural coumarins: molecular insights and experimental validation DOI
Emadeldin M. Kamel,

Sarah I. Othman,

Faris F. Aba Alkhayl

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(6)

Published: May 15, 2025

Language: Английский

Mechanistic insights into alkaloid-based inhibition of squalene epoxidase: A combined in silico and experimental approach for targeting cholesterol biosynthesis DOI
Emadeldin M. Kamel,

Sarah I. Othman,

Faris F. Aba Alkhayl

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140609 - 140609

Published: Feb. 1, 2025

Language: Английский

Citations

7
Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics DOI Creative Commons
Emadeldin M. Kamel,

Sarah I. Othman,

Hassan A. Rudayni

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3829 - 3848

Published: Jan. 1, 2025

Apigenin-7-O-glucoside, silibinin, and baicalin are potent squalene epoxidase inhibitors with promising therapeutic potential. Integrative in silico experimental studies pave the way for hypercholesterolemia antifungal therapies.

Language: Английский

Citations

7
Comprehensive Insights into Carbonic Anhydrase Inhibition: A Triad of In vitro, In silico, and In vivo Perspectives DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

et al.

Enzyme and Microbial Technology, Journal Year: 2025, Volume and Issue: 189, P. 110657 - 110657

Published: April 17, 2025

Language: Английский

Citations

0
Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Squalene epoxidase (SQLE) is a pivotal enzyme in sterol biosynthesis, catalyzing the conversion of squalene to 2,3-oxidosqualene. Beyond its core role cholesterol homeostasis, SQLE implicated cancer, hypercholesterolemia, and fungal infections, positioning it as valuable therapeutic target. We conducted comprehensive literature search across primary databases gather vitro, silico, vivo evidence on SQLE. This review explores enzyme's structural functional features, including substrate specificity catalytic mechanisms, examines inhibitor interactions. Computational methods predict - dynamics, guiding drug design, while investigations clarify SQLE's metabolic disorders tumorigenesis. Challenges include resistance study discrepancies, but emerging technologies, such cryo-electron microscopy CRISPR editing, offer new avenues for deeper exploration. an underexplored yet promising target, with particular relevance oxidative stress, ferroptosis, gut microbiota research. Overcoming current barriers through advanced technologies multidisciplinary strategies could propel SQLE-targeted treatments into clinical practice, supporting precision medicine broader translational applications.

Language: Английский

Citations

0
Multi-pronged approaches to the mechanism-based inactivation of aldose reductase by natural coumarins: molecular insights and experimental validation DOI
Emadeldin M. Kamel,

Sarah I. Othman,

Faris F. Aba Alkhayl

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(6)

Published: May 15, 2025

Language: Английский

Citations

0