Critical Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21
Published: May 9, 2025
Indole was first identified around 1869, this being an indole ring system which is a fused benzene and pyrrole system. Research findings illustrate that derivatives have gained acceptance as therapeutic agents because they contain structural versatility access different biological targets. Scientific research has established their strong pharmaceutical properties, especially for oncology medicines control essential cellular processes while interrupting defective enzymatic activities of topoisomerases, kinases, histone deacetylases. proves indole-based compounds display broad antibacterial, antifungal antiparasitic effects in addition to cancer-fighting properties. The nucleus creates targeted interactions with central nervous receptors enzymes visualization neurological delivery. indicates provide benefits managing anti-inflammatory responses lowering blood pressure diabetes markers although benefiting cardiovascular health through ability affect specific disease pathways. ongoing development optimization methods synthetic improvements leads surpass present treatments according clinical trials. Structural modifications the core been explored recent studies improve its pharmacological versatility. from 2020 2024, featuring potency, mechanism action, strategies overcome resistance, highlighted, focus on diseases. Finds databases such ScienceDirect, Google Scholar, PubMed, EMBASE are included analysis.
Language: Английский