Photosensitizer Delivery and Improved Anticancer Photodynamic Application Using Redox‐Sensitive Nanocarriers DOI
Elina E. Mansurova, M. M. Shulaeva, Anna P. Lyubina

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract This study introduces innovative redox‐sensitive polymeric nanocarriers designed to deliver the photosensitizer meso ‐tetra( N ‐methyl‐4‐pyridyl)porphine and enhance anticancer photodynamic therapy. These release from a hydrophobic core in response elevated glutathione levels, enabling generation of reactive oxygen species upon irradiation. The glutathione‐sensitive is constructed using disulfide‐linked molecules, while hydrophilic shell, consisting 6‐methyluracil derivative, enhances stability promotes cellular uptake photosensitizer. paper details synthesis, physicochemical properties, encapsulation efficiency nanocarriers. It further explores how structure influences glutathione‐induced degradation, kinetics, under Additionally, evaluates hemocompatibility photosensitizer/nanocarrier composites their cytotoxic effects on human liver cells (Chang Liver), healthy embryonic lung (WI38), cancer cell lines (M‐HeLa HuTu80). Notably, treatment with these composites, followed by irradiation, significantly reduces viability M‐HeLa line, demonstrating potential for targeted

Language: Английский

Photosensitizer Delivery and Improved Anticancer Photodynamic Application Using Redox‐Sensitive Nanocarriers DOI
Elina E. Mansurova, M. M. Shulaeva, Anna P. Lyubina

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract This study introduces innovative redox‐sensitive polymeric nanocarriers designed to deliver the photosensitizer meso ‐tetra( N ‐methyl‐4‐pyridyl)porphine and enhance anticancer photodynamic therapy. These release from a hydrophobic core in response elevated glutathione levels, enabling generation of reactive oxygen species upon irradiation. The glutathione‐sensitive is constructed using disulfide‐linked molecules, while hydrophilic shell, consisting 6‐methyluracil derivative, enhances stability promotes cellular uptake photosensitizer. paper details synthesis, physicochemical properties, encapsulation efficiency nanocarriers. It further explores how structure influences glutathione‐induced degradation, kinetics, under Additionally, evaluates hemocompatibility photosensitizer/nanocarrier composites their cytotoxic effects on human liver cells (Chang Liver), healthy embryonic lung (WI38), cancer cell lines (M‐HeLa HuTu80). Notably, treatment with these composites, followed by irradiation, significantly reduces viability M‐HeLa line, demonstrating potential for targeted

Language: Английский

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