Chemosphere,
Journal Year:
2022,
Volume and Issue:
299, P. 134474 - 134474
Published: March 31, 2022
Salinity
is
a
global
issue
limiting
efficient
agricultural
production.
Nano-enabled
plant
salt
tolerance
hot
topic.
However,
the
role
of
nanoparticles
induced
possible
early
stimulation
on
antioxidant
system
in
its
improved
still
largely
unknown.
Here,
poly
(acrylic)
acid
coated
nanoceria
(cerium
oxide
nanoparticles)
(PNC,
7.8
nm,
-31
mV)
with
potent
ROS
(reactive
oxygen
species)
scavenging
ability
are
used.
Compared
control,
no
significant
difference
H2O2
and
O2•─
content,
MDA
(malondialdehyde)
relative
electric
conductivity,
Fv/Fm
was
found
leaves
and/or
roots
cucumber
before
onset
salinity
stress,
regardless
leaf
or
root
application
PNC.
While,
compared
activities
SOD
(superoxide
dismutase,
up
to
1.8
folds
change),
POD
(peroxidase,
2.5
change)
CAT
(catalase,
2.3
content
GSH
(glutathione,
3.0
ASA
(ascorbic
acid,
2.4
PNC
spray
were
significantly
increased.
RNA
seq
analysis
further
confirmed
that
foliar
upregulates
more
genes
over
than
application.
These
results
showed
sprayed
have
stronger
effect
applied
one
sensitive
root.
After
plants
better
improvement
one.
Also,
higher
whole
cerium
after
stress.
In
summary,
we
optimal
terms
improving
tolerance,
this
associated
plants.
Small,
Journal Year:
2021,
Volume and Issue:
18(3)
Published: Nov. 27, 2021
Abstract
Metal‐free
carbon
nanozymes
could
be
promising
with
the
unique
features
of
intrinsic
catalytic
ability,
structure
diversity,
and
strong
tolerance
to
acidic/alkaline
media.
However,
date,
study
metal‐free
fell
far
behind
metal‐based
nanomaterials,
in
which,
majority
reported
much
more
peroxidase‐like
activity
than
other
enzyme‐mimicking
behavior
(e.g.,
oxidase).
Thus,
exploit
high‐performance
is
importance
but
challenging.
In
this
work,
nitrogen‐rich
conjugated
polymer
(Aza‐CPs)
rigid
network
utilized
as
precursor
yield
N
‐doped
material
QAU‐Z1
high
via
a
direct
pyrolysis
method.
Surprisingly,
stood
out
oxidase‐like
behavior,
which
significantly
outperformed
control
materials
GNC‐900
QAU‐Z2
nucleobase
or
small
molecule
precursor,
respectively.
More
importantly,
it
crucial
revelation
that
performance
closely
related
change
zeta
potential
for
nanozyme
during
substrate
3,3′,5,5′‐tetramethylbenzidine
oxidation
process,
well
its
catalytical
capacity
O
2
,
insightful
understand
inherent
mechanism.
This
work
not
only
presents
polymers
constructing
highly
efficient
nanozyme,
also
reveals
vital
role
interaction
mode
between
performance.
Small,
Journal Year:
2021,
Volume and Issue:
17(51)
Published: Aug. 6, 2021
Research
on
cerium
oxide
nanoparticles
(nanoceria)
has
captivated
the
scientific
community
due
to
their
unique
physical
and
chemical
properties,
such
as
redox
activity
oxygen
buffering
capacity,
which
made
them
available
for
many
technical
applications,
including
biomedical
applications.
The
mimetic
antioxidant
properties
of
nanoceria
have
been
effective
in
treatment
diseases
caused
by
reactive
species
(ROS)
nitrogen
species.
mechanism
ROS
scavenging
is
still
elusive,
its
controversial
mixed
reports
literature
showing
pro-oxidant
activity.
In
lieu
current
research
interest,
it
critical
understand
behaviour
biological
environment
provide
answers
some
open
issues.
This
review
critically
analyses
status
application
treat
ROS.
It
reviews
proposed
action
shows
effect
surface
coatings
also
discusses
crucial
issues
deciphering
suggests
areas
future
research.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(1)
Published: Jan. 25, 2022
Abstract
Nanozymes
are
nanomaterials
with
similar
catalytic
activities
to
natural
enzymes.
Compared
enzymes,
they
have
numerous
advantages,
including
higher
physiochemical
stability,
versatility,
and
suitability
for
mass
production.
In
the
past
decade,
synthesis
of
nanozymes
their
mechanisms
advanced
beyond
simple
replacement
allowing
fascinating
applications
in
various
fields
such
as
biosensing
disease
treatment.
particular,
exploration
powerful
toolkits
diagnostic
viral
testing
antiviral
therapy
has
attracted
growing
attention.
It
can
address
great
challenges
faced
by
current
enzyme‐based
technologies,
high
cost
storage
difficulties.
Therefore,
nanozyme
provide
a
novel
nanozyme‐based
therapeutic
regime
broader
availability
generalizability
that
keys
fighting
pandemic
COVID‐19.
Herein,
we
timely
review
state‐of‐the‐art
regarding
activities,
well
focused
discussion
on
recent
research
into
use
therapy.
The
remaining
future
perspectives
will
also
be
outlined.
Ultimately,
this
inform
readers
knowledge
inspire
more
innovative
studies
push
forward
frontier
field.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(35)
Published: April 26, 2022
Abstract
Ischemic
heart
disease
(IHD)
is
the
leading
cause
of
disability
and
mortality
worldwide.
Reactive
oxygen
species
(ROS)
have
been
shown
to
play
key
roles
in
progression
diabetes,
hypertension,
hypercholesterolemia,
which
are
independent
risk
factors
that
lead
atherosclerosis
development
IHD.
Engineered
biomaterial‐based
nanomedicines
under
extensive
investigation
exploration,
serving
as
smart
multifunctional
nanocarriers
for
synergistic
therapeutic
effect.
Capitalizing
on
cell/molecule‐targeting
drug
delivery,
present
enhanced
specificity
safety
with
favorable
pharmacokinetics
pharmacodynamics.
Herein,
ROS
both
IHD
its
discussed,
highlighting
cardiovascular
medications
antioxidant
properties,
summarizing
advantages,
recent
achievements
scavenging
capacity
treatment
atherosclerosis,
ischemia/reperfusion,
myocardial
infarction.
Finally,
current
challenges
ROS‐scavenging
possible
future
directions
discussed
from
a
clinical
perspective.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: May 17, 2023
Organoids
are
three-dimensional
(3D)
miniaturized
versions
of
organs
or
tissues
that
derived
from
cells
with
stem
potential
and
can
self-organize
differentiate
into
3D
cell
masses,
recapitulating
the
morphology
functions
their
in
vivo
counterparts.
Organoid
culture
is
an
emerging
technology,
organoids
various
tissues,
such
as
brain,
lung,
heart,
liver,
kidney,
have
been
generated.
Compared
traditional
bidimensional
culture,
organoid
systems
unique
advantage
conserving
parental
gene
expression
mutation
characteristics,
well
long-term
maintenance
function
biological
characteristics
vitro.
All
these
features
open
up
new
opportunities
for
drug
discovery,
large-scale
screening,
precision
medicine.
Another
major
application
disease
modeling,
especially
hereditary
diseases
difficult
to
model
vitro
modeled
by
combining
genome
editing
technologies.
Herein,
we
introduce
development
current
advances
technology
field.
We
focus
on
applications
basic
biology
clinical
research,
also
highlight
limitations
future
perspectives.
hope
this
review
provide
a
valuable
reference
developments
organoids.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(10)
Published: Feb. 16, 2023
Abstract
The
growing
interest
in
nanomedicine
over
the
last
20
years
has
carved
out
a
research
field
called
“nanocatalytic
therapy,”
where
catalytic
reactions
mediated
by
nanomaterials
are
employed
to
intervene
disease‐critical
biomolecular
processes.
Among
many
kinds
of
catalytic/enzyme‐mimetic
investigated
thus
far,
ceria
nanoparticles
stand
from
others
owing
their
unique
scavenging
properties
against
biologically
noxious
free
radicals,
including
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS),
exerting
enzyme
mimicry
nonenzymatic
activities.
Much
effort
been
made
utilize
as
self‐regenerating
antioxidative
anti‐inflammatory
agents
for
various
diseases,
given
detrimental
effects
ROS
RNS
therein
that
need
alleviation.
In
this
context,
review
is
intended
provide
an
overview
what
makes
merit
attention
disease
therapy.
introductory
part
describes
characteristics
oxygen‐deficient
metal
oxide.
pathophysiological
roles
then
presented,
well
mechanisms
nanoparticles.
Representative
examples
recent
ceria‐nanoparticle‐based
therapeutics
summarized
categorization
into
organ
types,
followed
discussion
on
remaining
challenges
future
directions.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
25, P. 95 - 106
Published: Jan. 26, 2023
The
excessive
reactive
oxygen
species
(ROS)
is
a
hallmark
associated
with
the
initiation
and
progression
of
inflammatory
bowel
disease
(IBD),
which
execrably
form
vicious
cycle
ROS
inflammation
to
continually
promote
progression.
Here,
gold
nanoparticles-embedded
ceria
nanoparticles
(Au/CeO2)
enhanced
antioxidant
activities
are
designed
block
this
reaction
for
treating
IBD
by
scavenging
overproduced
ROS.
Au/CeO2
core-shell
porous
structure
exhibits
significantly
higher
enzymatic
catalytic
compared
commercial
nanoparticles,
likely
due
effective
exposure
sites,
content
Ce
(III)
vacancy,
accelerated
reduction
from
(IV)
(III).
Being
coated
negatively-charged
hyaluronic
acid,
Au/CeO2@HA
facilitates
accumulation
in
inflamed
colon
tissues
via
oral
administration,
reduces
pro-inflammatory
cytokines,
effectively
alleviates
injury
colitis
mice.
Overall,
good
biocompatibility
promising
nano-therapeutic
IBD.
Cellular and Molecular Life Sciences,
Journal Year:
2023,
Volume and Issue:
80(2)
Published: Jan. 19, 2023
Abstract
Nanoceria
or
cerium
oxide
nanoparticles
characterised
by
the
co-existing
of
Ce
3+
and
4+
that
allows
self-regenerative,
redox-responsive
dual-catalytic
activities,
have
attracted
interest
as
an
innovative
approach
to
treating
cancer.
Depending
on
surface
characteristics
immediate
environment,
nanoceria
exerts
either
anti-
pro-oxidative
effects
which
regulate
reactive
oxygen
species
(ROS)
levels
in
biological
systems.
mimics
ROS-related
enzymes
protect
normal
cells
at
physiological
pH
from
oxidative
stress
induce
ROS
production
slightly
acidic
tumour
microenvironment
trigger
cancer
cell
death.
nanozymes
also
generates
molecular
relieves
hypoxia,
leading
sensitisation
improve
therapeutic
outcomes
photodynamic
(PDT),
photothermal
(PTT)
radiation
(RT),
targeted
chemotherapies.
has
been
engineered
a
nanocarrier
drug
delivery
combination
with
other
drugs
produce
synergistic
anti-cancer
effects.
Despite
reported
preclinical
successes,
there
are
still
knowledge
gaps
arising
inadequate
number
studies
reporting
findings
based
physiologically
relevant
disease
models
accurately
represent
complexities
This
review
discusses
activities
responding
tension
gradient
microenvironment,
highlights
recent
nanoceria-based
platforms
be
feasible
direct
indirect
agents
protective
healthy
tissues,
finally
addresses
challenges
clinical
translation
therapeutics.
