Visualizing Singularity Phenomenon DOI Creative Commons
Tomonobu M. Watanabe,

Tsuyoshi Shiina

Biophysics and Physicobiology, Journal Year: 2024, Volume and Issue: 21(Supplemental), P. n/a - n/a

Published: Jan. 1, 2024

In a multicellular system, cells interact and communicate with the surrounding cells.A small number of that considerably impact emerge, either by chance or necessity.When cell-cell interaction centered in these minority triggers an avalanche interactions, system irreversibly undergoes phase transition collective state cells.In case is essential fatal for life phenomena, such as development, metamorphosis, lesions, cell defined "singularity cell," phenomenon."This definition nominal.Systems constantly undergo transitions physical regardless whether observer looking.Based on this definition, humans can explore mechanisms only exist rather than complex combinations principles.In conventional biology, which based statistical quantification using average values, emergence singularity recognized outlier has not been experimentally predicted because its extreme rarity.In recent years, owing to development single-cell omics technologies, experimental data sciences have become more voluminous, enabling detection rare-emerged cells.However, they could prove causal relationship between lack temporal information data.It necessary measure dynamic parameters quantitatively represent screening express detail discover cells.The basic procedure identifying follows: (1) macroscopically detect entire system; (2) microscopically retrogradely search all candidates starting (or) interaction; (3) theoretically mathematically screen candidate causally related transition.Therefore, first principle visualization biology "see forest trees."This means behaviors interactions comprise everywhere, simultaneous observation behavior system.This poses dilemmas measurement systems, example, wide field view high resolution are incompatible optical microscope.Innovations elemental technology will gradually resolve dilemmas; abovementioned incompatibility be overcome specially upsizing apertures objective lens detector [1,2].On other hand, era specification improvements but also simplifying lowering prices needed, various trials biological events what establish new discipline.Research management team overcame dilemma combination simple machinery.They adopted machine vision camera telecentric macro instead at expense three-

Language: Английский

J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores DOI
Xiaoming Hu,

Caijun Zhu,

Fengwei Sun

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

Citations

68
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

19
Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine DOI
Mei Yang,

Yongqi Han,

Alberto Bianco

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(18), P. 11560 - 11572

Published: April 29, 2024

Second near-infrared (NIR-II) carbon dots, with absorption or emission between 1000 and 1700 nm, are gaining increasing attention in the biomaterial field due to their distinctive properties, which include straightforward preparation processes, stable photophysical characteristics, excellent biocompatibility, low cost. As a result, there is growing focus on controlled synthesis modulation of photochemical properties NIR-II aim further expand biomedical applications, current research hotspot. This account aims provide comprehensive overview recent advancements dots within field. The review will cover following topics: (i) design, synthesis, purification (ii) surface modification strategies, (iii) particularly domain cancer theranostics. Additionally, this addresses challenges encountered by outline future directions realm By exploring carbon-based biomaterials, we can anticipate that contribution garner increased contribute development next-generation advanced functional thereby offering enhanced tools strategies

Language: Английский

Citations

18
Dependence of Extinction Cross-Section, Absorption and Surface Plasmon Resonance of Nanoparticle Surface Size and Concentration of Silica@Gold Nanoparticles DOI
Hassan Nasiri, Mohammad Salahandish, Hadi Sharifi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Gold-coated nanoparticles have garnered significant attention in recent years due to their exceptional thermal stability and distinct optical properties. This paper investigates the characteristics of various nanoparticles, including Silica, Gold, Silica using Mie theory, Gan's effective medium approach. Plasmonic been extensively studied for medical applications across scientific fields. Their surface plasmon resonance remarkable ability absorb scatter light revolutionized diagnosis, treatment, assessment numerous diseases, particularly cancer. One valuable these linked plasmonic properties, is use photothermal therapy cancer treatment. Nanoparticle-based phototherapy has emerged as one most treatment methods years, owing its high efficiency destroying cancerous tumors while minimizing side effects.

Language: Английский

Citations

2
Advances in near-infrared-activated lanthanide-doped optical nanomaterials: imaging, sensing, and therapy DOI Creative Commons
Hao Li, Gongxun Bai,

Yanbang Lian

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 231, P. 112036 - 112036

Published: May 25, 2023

As the population ages, cancer has become a major health concern. Although surgical treatment, chemoradiotherapy, and other clinical treatments have dominant, their strong invasiveness intolerable toxic side effects seriously affect patients' quality of life. Therefore, developing non-invasive optical therapy with high safety is great significance. In last two decades development, progress been made in lanthanide doped nanoparticles on biomedical applications under near-infrared (NIR) light due to unique properties. These nanomaterials used wide range applications, including bioluminescence marker detection, vitro vivo imaging, photodynamic (PDT), photothermal (PTT), therapeutic applications. therapies rapidly developed profession involving oncology non-invasive, spatiotemporal controllability, efficiency. For this key review, based listed as follows: bioimaging, biosensors, PDT PTT. Some emerging biological lanthanide-doped currently at forefront nano/biological interface are also discussed. Finally, review summarizes future opportunities challenges nanotechnology research nanoparticles.

Language: Английский

Citations

27
Emerging NIR-II Luminescent Gold Nanoclusters for In Vivo Bioimaging DOI
Siqi Ni, Yizhuo Liu,

Shufen Tong

et al.

Journal of Analysis and Testing, Journal Year: 2023, Volume and Issue: 7(3), P. 260 - 271

Published: Aug. 14, 2023

Language: Английский

Citations

23
Enhancing NIR‐II Upconversion Monochromatic Emission for Temperature Sensing DOI
Xiaomeng Liu,

Tongtong Liu,

Langping Tu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(27)

Published: Jan. 28, 2024

The upconversion luminescence (UCL) in the second near-infrared window (NIR-II) is highly attractive due to its excellent performance high-resolution bioimaging, anticounterfeiting, and temperature sensing. However, upconvertion nanoparticles (UCNPs) are normally emitted visible light, potentially impacting imaging quality. Here, a monochromatic Er

Language: Английский

Citations

13
Preparation of rare earth-doped nano-fluorescent materials in the second near-infrared region and their application in biological imaging DOI

Hetong Zhu,

Xin Ding, Chang Wang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(8), P. 1947 - 1972

Published: Jan. 1, 2024

Advantages of rare earth-doped nanoparticles in second near-infrared fluorescence imaging and commonly used earth ions.

Language: Английский

Citations

11
Brightness Strategies toward NIR-II Emissive Conjugated Materials: Molecular Design, Application, and Future Prospects DOI
Xiliang Li, Huan Chen,

Zihan Su

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.

Language: Английский

Citations

10
Gold Nanoclusters as High Resolution NIR-II Theranostic Agents DOI Creative Commons
Nancy Sharma,

Walaa Mohammad,

Xavier Le Guével

et al.

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: 2(7), P. 462 - 480

Published: June 18, 2024

In the realm of nanomaterials, atomically precise quasi-molecular gold nanoclusters (AuNCs) play a prime role due to their unique, stable, and highly tunable optical properties. They are extensively structure-engineered for modulation surface electronic states toward long wavelength photoluminescence, particularly in NIR-II (1000 1700 nm) window. Contrast agents with emission can potentially transform imaging terms higher spatial resolution, deeper tissue penetration, reduced autofluorescence. These advantages allow real-time living organisms observing disease progression treatment response. this short review, we discuss origin rationally designed AuNCs application high resolution vasculatures hard soft structures identification pathological conditions such as stroke injury. Further, recent employment these rapidly growing field tumor theranostics is also summarized. Final remarks provided on scope improvement properties persisting challenges clinical translation.

Language: Английский

Citations

9