ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 7535 - 7543
Published: Oct. 12, 2024
The
search
for
drug
nanocarriers
with
stimuli-responsive
properties
and
high
payloads
targeted
delivery
precision
medicine
is
currently
a
focal
point
of
biomedical
research,
but
this
endeavor
still
encounters
various
challenges.
Herein,
porous
organic
cage
(POC)
applied
to
paclitaxel
(PTX)
cancer
therapy
the
first
time.
Specifically,
water-soluble,
stable,
biocompatible
POC-based
nanocapsules
(PTX@POC@RH40)
PTX
encapsulation
efficiency
over
98%
can
be
synthesized
by
simply
grafting
nonionic
surfactant
(Polyoxyl
40
hydrogenated
castor
oil,
RH40)
on
POC
surface.
These
PTX@POC@RH40
demonstrate
remarkable
stability
more
than
week
without
aggregation
exhibit
pH-responsive
behavior
under
acidic
conditions
(pH
5.5)
display
sustained
release
at
both
pH
7.4
5.5.
Intravenous
administration
led
3.5-fold
increase
in
bioavailability
compared
free
group
rats.
Moreover,
vivo
mouse
model
experiments
involving
4T1
subcutaneous
breast
tumors
revealed
that
exhibited
enhanced
anticancer
efficacy
minimal
toxicity
PTX.
findings
underscore
potential
POCs
as
promising
therapeutic
applications.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23262 - 23298
Published: Nov. 27, 2023
Cancer
stem
cells
(CSCs)
drive
tumor
initiation,
progression,
and
therapeutic
resistance
due
to
their
self-renewal
differentiation
capabilities.
Despite
encouraging
progress
in
cancer
treatment,
conventional
approaches
often
fail
eliminate
CSCs,
necessitating
the
development
of
precise
targeted
strategies.
Recent
advances
materials
science
nanotechnology
have
enabled
promising
CSC-targeted
approaches,
harnessing
power
tailoring
nanomaterials
diverse
applications.
This
review
provides
an
update
on
current
landscape
nanobased
precision
targeting
against
CSCs.
We
elucidate
nuanced
application
organic,
inorganic,
bioinspired
across
a
spectrum
paradigms,
encompassing
therapy,
immunotherapy,
multimodal
synergistic
therapies.
By
examining
accomplishments
challenges
this
potential
field,
we
aim
inform
future
efforts
advance
nanomaterial-based
therapies
toward
more
effective
"sniping"
CSCs
clearance.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Cancer
immunotherapy,
which
leverages
the
body's
immune
system
to
combat
cancer,
offers
promise
of
lower
toxicity
and
higher
therapeutic
efficacy
compared
conventional
treatments.
However,
current
immunotherapeutic
approaches
face
significant
challenges
including
variable
patient
response,
immune‐related
adverse
events,
high
costs,
underscoring
urgent
need
for
innovative
strategies.
Metal‐based
nanomaterials
have
emerged
as
a
promising
avenue
in
cancer
immunotherapy
due
their
unique
physicochemical
properties
immune‐regulating
capabilities.
Despite
potential,
concerns
about
toxicity,
incomplete
understanding
modulation
mechanisms,
early‐stage
design
strategies
hinder
clinical
translation.
This
review
summarizes
recent
advancements
metal‐based
elucidates
mechanisms
by
they
enhance
antitumor
immunity
responses,
explores
potential
synergistic
effects
combining
multiple
metals.
We
also
discuss
key
future
perspectives
application,
aiming
provide
theoretical
foundation
development
immunotherapies
promote
broader
application
treatment.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 2, 2025
GTPase
IMAP
family
member
8
(GIMAP8)
plays
a
key
role
in
pathophysiology
of
several
malignancies.
The
objective
this
current
research
endeavor
was
to
investigate
the
prognosis
value
GIMAP8
lung
adenocarcinoma
and
examine
how
it
relates
immunity.
Expression
profiles
associated
with
related
clinical
details
were
acquired
from
Cancer
Genome
Atlas
database,
we
conducted
survival
analysis,
enrichment
analysis
immune
infiltration
studies.
Additionally,
evaluated
effect
on
radiation
resistance
tumor
by
vivo
vitro
experiments.
Our
results
showed
that
tissues
exhibited
lower
levels
compared
nearby
normal
tissues.
Furthermore,
decreased
expression
strongly
correlated
poorer
OS.
is
closely
formation
cells.
GSEA
identified
multiple
signaling
pathways
linked
GIMAP8,
including
immune-related,
chemokine,
cell
adhesion
molecule,
NF-κB
pathways.
checkpoint
molecules,
mutational
burden,
neoantigen
cells,
microenvironment.
found
have
an
inhibitory
response.
Moreover,
may
also
influence
tumors.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 5955 - 5955
Published: Aug. 8, 2023
As
a
therapeutic
tool
inherited
for
thousands
of
years,
traditional
Chinese
medicine
(TCM)
exhibits
superiority
in
tumor
therapy.
The
antitumor
active
components
TCM
not
only
have
multi-target
treatment
modes
but
can
also
synergistically
interfere
with
growth
compared
to
chemotherapeutics.
However,
most
the
characteristics
poor
solubility,
high
toxicity,
and
side
effects,
which
are
often
limited
clinical
application.
In
recent
delivering
by
nanosystems
has
been
promising
field.
advantages
nano-delivery
systems
include
improved
water
targeting
efficiency,
enhanced
stability
vivo,
controlled
release
drugs,
achieve
higher
drug-delivery
efficiency
bioavailability.
According
method
drug
loading
on
nanocarriers,
be
categorized
into
two
types,
including
physically
encapsulated
nanoplatforms
chemically
coupled
platforms.
this
review,
approaches
considered,
namely
physical
encapsulation
chemical
coupling,
both
commonly
used
deliver
TCM,
we
summarized
limitations
different
types
systems.
Meanwhile,
applications
potential
toxicity
future
development
challenges
these
discussed,
aiming
lay
foundation
practical
application
settings.
Photofunctional
nanomaterials
have
shown
great
potential
in
biomedical
applications
due
to
their
unique
optical
properties
and
size
effects.
This
chapter
focuses
on
"General
Introduction
Background
of
Nanomaterials
Biomedical
Applications."
First,
a
brief
introduction
is
given,
describing
basic
importance
various
fields.
Secondly,
the
concepts
photofunctional
physicochemical
effects
under
light
conditions,
such
as
photothermal
effect,
photoluminescence,
photovoltaic
photochemical
are
presented.
Next,
an
overview
nanobiomedicine
presented,
highlighting
for
applications.
Then,
different
types
nanomaterials,
including
fluorescent,
photothermal,
photodynamic,
photoelectrochemical
photoacoustic
discussed
detailed
classification
fields
bioimaging,
antimicrobial,
oncological
diagnosis
treatment,
biodetection
sensing
discussed.
Finally,
current
research
results
summarized
future
development
field
envisaged.
