Carbon and 2D nanomaterial smart hydrogels for therapeutic applications

Nanotechnology Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 1, 2025

Abstract Smart hydrogels, also known as environmentally responsive are a kind of intelligent polymer-based material network undergoing deformation and phase changes under external environmental stimuli. These special physicochemical properties make hydrogels great molecular systems for applications in controlled drug release. Particularly, loaded with nanomaterials show strong potential terms mechanical responsiveness. In this context, the use carbon two-dimensional (2D) has attracted widespread attention, they can trigger This review provides an overview current progress design biocompatible containing 2D nanomaterials, focusing on their preparation, properties, advantages release to treat different diseases such cancer, diabetes, inflammation.

Language: Английский

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Bimodal Poly(lactic-co-glycolic acid) Nanocarrier with Zinc Oxide and Iron Oxide for Fluorescence and Magnetic Resonance Imaging

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1818 - 1818

Published: April 18, 2025

Zinc oxide (ZnO) and iron (IO) nanoparticles have been identified as promising candidates for biomedical applications, based on their unique physicochemical properties. The association of these in a single system creates bimodal entity, allowing the excellent luminescent properties ZnO quantum dots to be combined with contrast agent IO magnetic resonance imaging (MRI). present study focuses MRI new poly(lactic-co-glycolic acid) (PLGA) nanocarrier formulation containing NPs different nominal ratios. Microscopic analysis (TEM SEM) reveals circular morphology NPs. average diameter particles was determined 220 nm, measured by DLS. luminescence results indicate that PLGA shows strong emission visible range, high r2 relaxivity 171 mM−1 s−1 at 7T. optimized formulation, exhibiting molar ratio Fe:Zn ranging from 1:10 1:13 (mol:mol), demonstrates superior fluorescence performance, underscoring significance nanoparticle composition applications. systems evaluated demonstrate no toxicity THP-1 cells doses up 128 µg mL−1, efficient labeling after 4 h incubation, yielding images T2 contrast. PLGA:ZnO:IO considerable potential platform diagnostic imaging.

Language: Английский

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Hyperpolarized ¹²⁹Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(25), P. 10152 - 10160

Published: May 31, 2024

Assessing the effectiveness of nanomedicines involves evaluating drug content at target site. Currently, most research focuses on monitoring signal responses from loaded drugs, neglecting changes caused by nanohosts. Here, we propose a strategy to quantitatively evaluate drugs detecting variations resulting alterations in microenvironment Specifically, hyperpolarized (HP) 129Xe atoms are employed as probes sense nanohosts' environment and generate specific magnetic resonance (MR) that indicates their accessibility. The introduction reduces available space nanohosts, leading crowded hinders access atoms. By employing source detect microenvironment, constructed three-dimensional (3D) map indicated concentration nanohosts established linear relationship measure within based corresponding MR signals. Using developed strategy, successfully quantified uptake living cells through HP imaging. Overall, proposed atom-sensing approach can be used monitor induced provides new perspective for quantitative evaluation presence various nanomedicines.

Language: Английский

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Self‐Healing Hyaluronic Acid‐based Hydrogel with miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Articular cartilage defects present a significant therapeutic challenge due to the inherent avascular and aneural characteristics of tissue. Gene therapy has emerged as promising strategy for regeneration, particularly through use functional RNA biomaterial‐assisted frameworks. In this study, an innovative gene‐activated self‐healing hydrogel is developed fabricated controlled release miR140‐5p, key regulator regeneration. The hydrogel, crosslinked via UV radiation, composed aminated hyaluronic acid modified photosensitizer (NB). To enhance scaffold's structural integrity gene delivery efficiency, mineralized silk fibroin miR140‐5p‐loaded MON‐PEI nanoparticles are incorporated. These findings demonstrate that novel (miR140‐5p‐CaP@mSF‐HA‐NB) effectively encapsulates releases exhibits excellent biocompatibility, promotes enhanced regeneration in both vitro vivo models. Therefore, holds potential clinical applications treatment articular defects.

Language: Английский

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Adsorption and detection tramadol in aqueous solution by fluorescent- magnetic molecularly imprinting polymers

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2023, Volume and Issue: 155, P. 105314 - 105314

Published: Dec. 22, 2023

Language: Английский

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