Carbon, Journal Year: 2024, Volume and Issue: unknown, P. 119971 - 119971
Published: Dec. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134606 - 134606
Published: Aug. 8, 2024
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139535 - 139535
Published: Jan. 5, 2025
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 71 - 99
Published: Feb. 13, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Solanesol (Sol) and chlorogenic acid (CHA) are naturally active compounds. Sol exhibits a significant free radical absorption ability strong antioxidant activity. CHA, typical phenolic acid, excellent anticancer, anti-inflammation, antibacterial properties. Herein, bifunctional nanomicelles (CI@SPK) were skillfully designed to take advantage of the unique properties CHA treat Alzheimer's disease (AD). Hydrophobic was modified with poly(ethylene glycol) self-assemble into stable (SP). could be encapsulated hydrophobic core these nanomicelles, which increased its bioavailability greatly. Short peptide K (CKLVFFAED) incorporated facilitate their crossing blood-brain barrier. Then, CI@SPK targeted AD lesion area, released in greater quantities help IR780 under irradiation an 808 nm laser, resulting synergistically scavenging reactive oxygen species (ROS) Sol. Consequently, demonstrated capabilities ROS, inhibiting β-amyloid (Aβ) aggregation, eventually modulating microglia phenotype from M1 M2 promote Aβ phagocytosis clearance. In vivo studies indicated that improved learning cognitive impairments APP/PS1 mice by reducing plaque inflammation, signifying potential value clinical application for treatment.
Language: Английский
Citations
0
Exploration, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
ABSTRACT Amyloid‐β (Aβ) deposition was an important pathomechanisms of Alzheimer's disease (AD). Aβ generation highly regulated by beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. The silence BACE1 function to slow down production accepted as effective strategy combating AD. Herein, interfering RNA, metallothionein (MT) and ruthenium complexes ([Ru(bpy) 2 dppz] 2+ ) were all loaded in Prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect triggered instantaneous opening blood‐brain barrier (BBB) enhanced delivery. siRNA slowed Cu chelation synergistically inhibited aggregation. Ruthenium (Ru) could real‐timely track degradation results indicated that significantly blocked aggregation attenuated Aβ‐induced neurotoxicity apoptosis vitro inhibiting ROS‐mediated oxidative damage mitochondrial dysfunction through regulating the Bcl‐2 family. vivo effectively improved APP/PS1 mice learning memory alleviating neural loss, neurofibrillary tangles activation astrocytes microglial cells BACE1, tau phosphorylation. Taken together, our findings validated siRNA‐loaded nanocomplexes BBB penetrability synergy
Language: Английский
Citations
0
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
ABSTRACT Alzheimer's disease (AD) is one of the most prevalent forms neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) recognized to play an essential role in pathophysiology AD. The Aβ species are known exist various forms, including soluble monomers, oligomers, and insoluble aggregates. Despite extensive efforts regulate aggregation, no successful medications have been developed date. Among strategies for AD treatment, phototherapy, photodynamic therapy (PDT), photothermal (PTT), photopharmacology, photobiomodulation (PBM) attracted increased attention because spatiotemporal controllability. Representative examples PDT, PTT, PBM discussed terms inhibitory mechanism, unique properties materials, design phototherapy modulators. major challenges against addressed promising prospects proposed. It concluded that noninvasive light‐assisted approaches will become a strategy intensifying modulation aggregation or promoting clearance thus facilitating treatment.
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137401 - 137401
Published: March 1, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1572 - 1572
Published: March 31, 2025
Peptide-functionalized nanomedicine has emerged as a transformative approach in precision therapeutics and diagnostics, leveraging the specificity of peptides to enhance performance nanocarriers, including gold nanoparticles, polymeric liposomes, mesoporous silica quantum dots. These systems enable targeted drug delivery, molecular imaging, biosensing, regenerative medicine, offering unparalleled advantages bioavailability, cellular uptake, therapeutic selectivity. This review provides comprehensive analysis peptide-functionalization strategies, nanocarrier design, their applications across oncology, neurodegenerative disorders, inflammatory diseases, infectious tissue engineering. We further discuss critical role physicochemical characterization, vitro vivo validation, regulatory considerations translating these technologies into clinical practice. Despite rapid progress peptide-functionalized platforms, challenges related stability, immune response, off-target effects, large-scale reproducibility remain key obstacles widespread adoption. Addressing through advanced peptide engineering, optimized synthesis methodologies, harmonization will be essential for integration. By bridging fundamental research with translational advancements, this an interdisciplinary roadmap next generation nanomedicines poised revolutionize therapy diagnostics.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Abstract Depression, a severe disorder affecting both physical and mental health, is commonly treated with first‐line antidepressants, which often exhibit limited efficacy due to poor penetration of the blood‐brain barrier (BBB) significant side effects, thus requiring exploitation biocompatible effective treatments. Recent studies suggest that depression closely linked an imbalance in oxidative stress subsequent inflammatory responses. Antioxidant therapies targeting are therefore emerging as promising strategies. In this study, exosome‐functionalized geniposide (GEN) self‐carried Prussian blue (PB) nanotherapeutic approach fabricated realize efficient BBB for synergistic therapy. The porous PB carrier possesses multi‐enzyme capabilities, can effectively scavenge accumulated ROS, protecting slightly acidic environment released GEN from oxidation, subsequently works simultaneously activate Nrf2‐ARE pathway, enhancing body's defense mechanisms synergistically. triple‐amplified anti‐oxidant strategy nanomaterial shown mitigate microglial activation reduction neuroplasticity, ultimately alleviating pathological markers depression. Overall, constructed nanomaterials underscore therapeutic potential anti‐oxidative removal ROS pathway treatment
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154265 - 154265
Published: July 24, 2024
Language: Английский
Citations
3