Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113531 - 113531
Published: April 1, 2025
Language: Английский
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113531 - 113531
Published: April 1, 2025
Language: Английский
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(22), P. 12371 - 12430
Published: Aug. 24, 2023
Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on photoresponsive materials have become a new trend in inactivation due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective promising strategy recent years. In process treatment, are excited by different wavelengths lights produce reactive oxygen species (ROS) or other toxic killing various microbes, such bacteria, viruses, fungi, parasites, algae. Therefore, this review timely summarizes latest progress PCAT field, with emphasis development antimicrobials (PCAMs), underlying mechanisms, design multiple practical applications local infections therapy, personal protective equipment, water purification, coatings, wound dressings, food safety, antibacterial textiles, air purification. Meanwhile, we also present challenges perspectives widespread implementation therapeutics. We hope result review, will flourish weapon against antibiotic
Language: Английский
Citations
149Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)
Published: Feb. 23, 2024
Abstract Antibacterial photocatalytic therapy (APCT) is one of the most promising non‐antibiotic treatment strategies for biofilm‐infected wounds and inflammation caused by drug‐resistant bacteria. However, it still faces issues such as inadequate single antibacterial capacity lack antioxidant capacity. In this study, a Z‐scheme heterojunction (Bi 2 S 3‐X @PDA) designed using polydopamine (PDA) shell firmly anchored to surface sulfur vacancy‐rich bismuth sulfide nanorods NRs). Under near‐infrared light hydrogen peroxide, Bi @PDA significantly improves efficiency reactive oxygen species generation shows nearly 100% broad‐spectrum effect against multiple bacterial strains biofilms in vitro. Interestingly, activity PDA remarkably downregulates expression pro‐inflammatory factors promotes macrophage reprogramming toward proregenerative M2 phenotype. mouse wound model methicillin‐resistant Staphylococcus aureus biofilm infection, effectively eliminates through APCT/mild photothermal therapy, while reducing normal tissues regulating immune microenvironment, thereby promoting rapid healing. Overall, light‐controlled strategy, which provides both anti‐inflammatory functions, reliable tool combating infection
Language: Английский
Citations
30Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 26, 2024
Carbon dots (CDs) are novel carbon-based nanomaterials that have been used as photosensitizer-mediated photodynamic therapy (PDT) in recent years due to their good photosensitizing activity. Photosensitizers (PSs) main components of PDT can produce large amounts reactive oxygen species (ROS) when stimulated by light source, which the advantages low drug resistance and high therapeutic efficiency. CDs generate ROS efficiently under irradiation therefore extensively studied disease local phototherapy. In tumor therapy, be PSs or PS carriers participate play an extremely important role. bacterial infectious diseases, exhibit bactericidal activity effective disrupting cell membranes leading death upon photoactivation. We focus on advances cancer bacteria with CDs, also briefly summarize mechanisms requirements for cancer, other diseases. discuss role combination potential future applications against pathogens.
Language: Английский
Citations
24Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)
Published: June 14, 2024
Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.
Language: Английский
Citations
18Small, Journal Year: 2024, Volume and Issue: 20(45)
Published: July 25, 2024
Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.
Language: Английский
Citations
17Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 1, 2024
The emergence of carbon dots (CDs) as anticancer agents had sparked a transformation in cancer research and treatment strategies. These fluorescent CDs, initially introduced the early 2000 s, possess exceptional biocompatibility, tunable fluorescence, surface modification capabilities, positioning them promising tools biomedical applications.
Language: Английский
Citations
11Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)
Published: July 27, 2024
Abstract The threat posed by antibiotic‐resistant bacteria and the challenge of biofilm formation has highlighted inadequacies conventional antibacterial therapies, leading to increased interest in photodynamic therapy (aPDT) recent years. This approach offers advantages such as minimal invasiveness, low systemic toxicity, notable effectiveness against drug‐resistant bacterial strains. Porphyrins their derivatives, known for high molar extinction coefficients singlet oxygen quantum yields, have emerged crucial photosensitizers aPDT. However, practical application is hindered challenges poor water solubility aggregation‐induced quenching. To address these limitations, extensive research focused on development porphyrin‐based nanomaterials aPDT, enhancing efficacy sterilization broadening range antimicrobial activity. review provides an overview various utilized aPDT eradication years, including porphyrin‐loaded inorganic nanoparticles, polymer assemblies, supramolecular metal–organic frameworks (MOFs), covalent organic (COFs). Additionally, insights into prospects offered, highlighting its potential implementation.
Language: Английский
Citations
11Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 385 - 399
Published: July 30, 2024
Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating infections. However, the excess ROS infection site after treatments may cause irreversible damage healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrO
Language: Английский
Citations
10Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(2)
Published: Feb. 3, 2025
Food microbial contamination results in serious food safety issues and numerous loss waste, presenting one of the most significant challenges facing global system. Photodynamic inactivation (PDI) technology, which combines light photosensitizers (PS) to provide antimicrobial effects, is an ideal nonthermal technique for industry. This review provides a comprehensive overview PDI beginning with fundamental photoactivation principles PS pathways photoinduced reactive oxygen species (ROS) generation. critical factor affecting efficiency, categorized into three types: organic, metal oxide-, carbon-based. systemically summarizes photophysical properties, vitro performances, potential enhancement strategies, advantages limitations each type PS. Furthermore, mechanisms technologies are analyzed at both microscopic molecular levels. Finally, current applications various systems discussed, along associated opportunities. Overall, this offers crucial insights optimizing advancing highlighting key suggesting future research directions enhance effectiveness scalability diverse applications.
Language: Английский
Citations
1Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(11)
Published: Dec. 6, 2023
Abstract Enhancing the covalent organic framework (COF)’s photocatalytic ability synergistically with gelling formulations remains an urgent challenge for extended bio‐applications. Herein, COF is homogeneously coated on oxidized carbon nanotube (OCNT) and coordinated by Fe 3+ to obtain tubular nanocomplex OCNT@COF‐Fe (O@CF). The results showed that photodynamic reactive oxygen species (ROS) generation of O@CF enhanced due wrapped OCNT , which can respectively serve as intermolecular charge transfer channel electron acceptors/substrates (O 2 H O) adsorbent narrow energy band gaps, increase light absorption, decrease photogenerated carrier recombination. Synergistically, exhibited pH‐dependent peroxidase catalase activities, further ROS relieved hypoxia, respectively. Meanwhile, possessed degradation coatings‐dependent photothermal performances. Then, evenly incorporated into Schiff base hydrogel via coating‐participated cross‐linking, electroconductive OCNT@COF‐Fe@Gel (O@CF@G). This O@CF@G not only improve mechanical properties pure gel but also inherit multifunction O@CF. Consequently, it well adhere diabetic wounds imbibition, drug‐resistant biofilm elimination, gram‐positive negative bacteria killing, hypoxia alleviation, intercellular electrical signal conduction, thus accelerating wound healing.
Language: Английский
Citations
20