Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: June 14, 2024
Despite
laparoscopic-guided
minimally
invasive
hepatectomy
emerging
as
the
primary
approach
for
resecting
hepatocellular
carcinoma
(HCC),
there
is
still
a
significant
gap
in
suitable
biomaterials
that
seamlessly
integrate
with
these
techniques
to
achieve
effective
hemostasis
and
suppress
residual
tumors
at
surgical
margin.
Electrospun
films
are
increasingly
used
wound
closure,
yet
employment
of
prefabricated
electrospun
during
HCC
resection
hindered
by
prolonged
operation
times,
complexity
implementation,
limited
visibility
surgery,
inadequate
postoperative
prevention
recurrence.
In
this
study,
montmorillonite-iron
oxide
sheets
integrated
into
polyvinylpyrrolidone
(PVP)
polymer
framework,
enhancing
resulting
PVP/montmorillonite-iron
(MI)
film
(abbreviated
PMI)
robustness,
hemostatic
capability,
magnetocaloric
properties.
contrast
vitro
films,
PMI
designed
be
formed
situ
on
liver
wounds
under
laparoscopic
guidance
hepatectomy.
This
design
affords
superior
adaptability,
facilitating
meticulous
closure
expeditious
hemostasis,
thereby
simplifying
operative
process
ultimately
alleviating
workload
healthcare
professionals.
Moreover,
when
exposed
an
alternating
magnetic
field,
can
efficiently
ablate
tumors,
significantly
augmenting
treatment
efficacy
HCC.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 100911 - 100911
Published: April 14, 2024
Precision
therapy
has
become
the
preferred
choice
attributed
to
optimal
drug
concentration
in
target
sites,
increased
therapeutic
efficacy,
and
reduced
adverse
effects.
Over
past
few
years,
sprayable
or
injectable
thermosensitive
hydrogels
have
exhibited
high
potential.
These
can
be
applied
as
cell-growing
scaffolds
drug-releasing
reservoirs
by
simply
mixing
a
free-flowing
sol
phase
at
room
temperature.
Inspired
their
unique
properties,
been
widely
delivery
treatment
platforms
for
precision
medicine.
In
this
review,
state-of-the-art
developments
are
investigated,
which
covers
from
thermo-gelling
mechanisms
main
components
biomedical
applications,
including
wound
healing,
anti-tumor
activity,
osteogenesis,
periodontal,
sinonasal
ophthalmic
diseases.
The
most
promising
applications
trends
of
also
discussed
light
features.
The Innovation Materials,
Journal Year:
2024,
Volume and Issue:
2(1), P. 100051 - 100051
Published: Jan. 1, 2024
<p>Magnetic
nanoparticle-mediated
hyperthermia
(MHT)
is
a
promising
tumor
theranostic
technology
due
to
its
noninvasive
nature
and
ability
penetrate
deep
tissues
without
greatly
damaging
normal
tissues.
To
advance
the
clinical
translation
application
of
MHT,
we
present
comprehensive
overview
topics
related
including
basic
physical
heating
principles,
magnetic
nanoparticle
design,
biological
effects
applications.
First,
fundamental
principles
through
which
nanoparticles
mediate
are
reviewed
in
detail.
Subsequently,
strategies
increase
magnetothermal
effect
MHT
highlighted.
Then,
multitechnology
integration
applications
precision
diagnosis
treatment
introduced.
Finally,
key
challenges
outlooks
for
purposes
discussed.</p>
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(44)
Published: Oct. 7, 2024
Abstract
Endometriosis
is
a
prevalent
gynecological
condition
characterized
by
chronic
pelvic
pain,
dysmenorrhea,
and
infertility,
affecting
≈176
million
women
of
reproductive
age
worldwide.
Current
treatments,
including
pharmacological
surgical
interventions,
are
often
associated
with
significant
side
effects
high
recurrence
rates.
Consequently,
there
an
urgent
need
for
innovative
safer
therapeutic
approaches.
In
this
study,
injectable
magnetic
hydrogel
nanosystem
developed
designed
the
dual‐purpose
magnetothermal
anti‐inflammatory
treatment
endometriosis.
This
incorporates
Fe
3
O
4
nanoparticles
alongside
peptide.
Upon
activation,
induce
localized
hyperthermic
response,
raising
temperature
endometriotic
lesions
to
63.3
°C,
effectively
destroying
cells.
Concurrently,
thermally
responsive
facilitates
controlled
release
peptide,
thus
modulating
inflammatory
milieu.
The
biocompatibility
complete
in
vivo
degradability
further
enhance
its
potential.
studies
demonstrated
that
system
achieved
90%
reduction
volume
significantly
decreased
markers,
offering
promising
non‐invasive
modality
By
integrating
precise
lesion
ablation
modulation
microenvironment,
represents
novel
approach
clinical
management
Percutaneous
local
thermal
therapy,
containing
radio
frequency
and
microwave
ablation,
is
widely
utilized
in
the
clinical
management
of
hepatocellular
carcinoma
(HCC)
due
to
its
minimal
invasiveness
favorable
therapeutic
outcomes.
However,
further
development
limited
by
a
prolonged
ablation
duration
risk
excessive
heating.
Magnetic
hyperthermia
therapy
(MHT)
provides
new
perspective
for
percutaneous
tumor
superior
tissue
penetration
capability
safety.
Herein,
an
iron
foam-agarose
gel-drug
(IF-Aga-drug)
implant
prepared
using
minimalistic
method
combination
HCC.
The
excellent
conductivity
IF
endows
it
with
strong
heating
owing
eddy
current
loss
alternating
magnetic
field
(AMF),
while
abundant
pores
provide
ample
space
drug
loading.
Agarose
gel
imparts
platform
universal
efficient
drug-loading
capacity
controlled
drug-release
that
responsive
hyperthermia.
Doxorubicin
(DOX)
as
representative
construct
IF-Aga-DOX
implant,
which
successfully
employed
ultrasound-guided,
hyperthermia-based
chemotherapy
orthotopic
HCC
rabbits
under
ultralow-power
intensities
(Happl·fappl
=
2.25
×
108
A
m-1
s-1).
developed
IF-Aga-drug
offers
convenient
versatile
strategy
therapy.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
design
strategies
for
external
stimuli-driven
hydrogels
with
in
situ
catalytic
processes.
It
highlights
precise
control
over
the
properties,
elucidating
regulatory
mechanisms
and
deepening
understanding
of
applications.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Magneto-driven
soft
robots
featuring
remote
and
highly
permeable
controllability
are
considered
promising,
especially
in
biomedical
engineering
applications.
However,
there
is
still
lack
of
a
high-precision
method
to
regulate
the
distribution
magnetic
fillers
polymer
substrates,
which
severely
limits
improvement
actuating
functionality.
This
work
provides
photo-regulatable
develop
with
locally
distributed
Fe3O4
nanoparticles.
Solvent-casted
polyvinyl
alcohol/sodium
carboxymethyl
cellulose
film
prepared
as
substrate,
Fe3+
ions
introduced
coordinate
carboxylate
groups
by
surface
treatment.
Two
processes,
photo-reduction
Fe2+
hydrolytic
reaction
two
ions,
sequentially
combined
situ
generate
particles.
Spatiotemporal
control
UV
light
irradiation
determines
Fe3+/Fe2+
ratio
and,
therefore
amount
generated
nanoparticles
that
decide
field,
NIR
light,
moisture
responsive
functionalities.
Moreover,
external
geometry
composite
can
be
tuned
inducing
formation
Al3+-carboxylate
coordinates
for
strain
retention,
enables
shape
programming
exhibit
complex
3D-3D
behaviors.
The
proposed
design
preparation
spatially
tunable
magnetism
more
advanced
Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Ultrasound-enabled
nanomedicine
leverages
ultrasound
to
amplify
the
capabilities
of
engineered
nanosystems,
paving
way
for
innovative
diagnostic
and
therapeutic
breakthroughs
in
conventional
nanomedicine.
As
a
burgeoning
discipline,
past
overviews
have
sometimes
offered
fragmented
perspective,
lacking
comprehensive
view.
This
review
presents
systematic
exploration
latest
advancements
ultrasound-enabled
nanomedicine,
with
particular
emphasis
on
oncology.
Covered
topics
include
molecular
imaging
tumors,
separation
tumor
markers,
penetration
through
physiological
barriers,
perforation
cell
membranes,
targeted
drug
release
activation
strategies,
an
array
sonotherapies
oncological
treatments.
We
delve
into
research
framework
each
topic,
foundational
design
their
associated
mechanisms.
Moreover,
we
highlight
recent
pivotal
aimed
at
deepening
reader's
understanding
this
intricate
domain.
underscores
integration
theories
within
aspiring
ignite
advanced
theoretical
insights
introduce
paradigms.
In
conclusion,
outline
current
challenges
prospective
directions.
An
enhanced
focus
these
areas
will
expedite
advancement
Journal of nano research,
Journal Year:
2024,
Volume and Issue:
84, P. 95 - 116
Published: Sept. 20, 2024
In
this
study,
CuFe
2
O
4
nanoparticles
with
an
average
crystallite
size
of
approximately
10
nm
were
produced
using
the
sol-gel
autocombustion
method.
The
synthesis
was
conducted
in
presence
polymers
varying
monomer
counts,
aiming
to
optimize
magnetic
properties
for
possible
localized
heating
applications.
Comprehensive
characterization
all
samples
X-ray
diffraction
(XRD),
scanning
electron
microscopy
(SEM),
Fourier-transform
infrared
spectroscopy
(FT-IR),
and
Mössbauer
spectroscopy.
All
synthesized
exhibited
good
colloidal
stability,
zeta
potentials
around
-18.49mV,
+3mV
+24
+30
mV.
Specific
Absorption
Rate
(SAR)
assessed
calorimetric
SAR
values
calculated
both
Initial
Slope
Box-Lucas
methods.
For
sample
citric
acid,
12.6
W/g
13.23
W/g,
respectively.
polyethylene
glycol,
ranged
from
3
7
W/g.
parameters
alternating
field
33.3
kA/m
357
kHz.
