Cited by Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications DOI

Bole Li,

Xiaotong Xu,

Yanfei Lv

et al.

Small, Journal Year: 2023, Volume and Issue: 20(3)

Published: Sept. 12, 2023

Abstract Artificial enzymes, as alternatives to natural have attracted enormous attention in the fields of catalysis, biosensing, diagnostics, and therapeutics because their high stability low cost. Polyoxometalates (POMs), a class inorganic metal oxides, recently shown great potential mimicking enzyme activity due well‐defined structure, tunable composition, catalytic efficiency, easy storage properties. This review focuses on recent advances POM‐based artificial enzymes. Different types POMs derivatives‐based mimetic functions are covered, well corresponding mechanisms (where available). An overview broad applications representative enzymes from biosensing theragnostic is provided. Insight into current challenges future directions for POMs‐based discussed.

Language: Английский

Citations

Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase DOI

Ran Hao,

Gangwan Zhang,

Jiahe Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 654, P. 212 - 223

Published: Oct. 11, 2023

Language: Английский

Citations

A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption DOI

Ke Liang, Fuchun Nan, Jian Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 23, 2024

Nanozyme-based metabolic regulation triggered by tumor-specific endogenous stimuli has emerged as a promising therapeutic strategy for tumors. The current efficacy, however, is constrained the limited concentration of substrates and plasticity Consequently, implementation efficient in tumor therapy urgently needed. Herein, versatile nanozyme-based nicotinamide adenine dinucleotide (NADH) circulating oxidation nanoreactor reported. First, synthesized cobalt-doped hollow carbon spheres (Co-HCS) possess NADH oxidase (NOX)-mimicking activity to disrupt oxidative phosphorylation (OXPHOS) pathway cells. Second, substrate-cycle manner Co-HCS can be used overcome limitation substrate deficiency. Finally, 2-Deoxy-D-glucose (2-DG) 6-aminonicotinamide (6-AN) are introduced block glycolysis pentose phosphate (PPP), thus creating (Co-HCS/D/A) through triple cellular metabolism disruption. In vitro vivo results demonstrate that designed not only enhances catalytic efficiency but also disrupts homeostasis, leading outcome. This study develops novel disruption, which addresses limitations therapy.

Language: Английский

Citations

Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

Citations

Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx DOI

Xiuxin Lu,

Yang Zheng,

Yan Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 667, P. 91 - 100

Published: April 10, 2024

Language: Английский

Citations