Electrical
stimulation
has
been
shown
to
enhance
tissue
regeneration,
which
is
why
piezoelectric-polymer-based
scaffolds
are
on
the
rise
for
advanced
tissue-engineering
approaches.
Recent
studies
have
that
electrical
cues
can
modulate
cell
function
in
vitro
and
vivo
these
be
delivered
through
application
of
an
external
noninvasive
ultrasound
(US)
source
actuate
a
piezoelectric
polymer.
However,
poly(l-lactide)
(PLLA)
possesses
shear
coefficient
therefore
requires
different
strategies
US
relative
other
well-established
materials
such
as
poly(vinylidene
fluoride-trifluoroethylene)
P(VDF-TrFE).
Thus,
this
work
compares
three
methods
ranging
from
1
500
kHz
(a
nanokicking
bioreactor,
transducer,
bath)
PLLA
diaphragm
with
aim
creating
bioelectrical
culture
device.
The
bath
stimulated
films
(37
kHz)
generated
output
voltage
548
±
16
mV,
highest
all
tested
systems.
nanokicker
(1.3
were
associated
4.8
0.7
probe
(500
actuated
9.1
0.8
still
high
enough
stimulation.
Moreover,
influence
film
tension
was
examined,
reduced
observed
increase
response
by
118%
reduce
P(VDF-TrFE)
24%.
This
shows
PLLA-based
designed
manner
take
advantage
effect
PLLA,
when
applying
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
ABSTRACT
The
periosteum
is
crucial
in
the
processes
of
bone
formation,
regeneration,
and
remodelling.
Specifically,
periosteal
progenitor
cells
contribute
a
major
force
to
initiation
healing.
Biomimetic
(BP),
employed
for
treating
defects,
exhibits
superior
outcomes
terms
integrity,
proper
vascularization,
minimal
heterotopic
ossification
when
compared
conventional
direct
graft
void
fillers.
Therefore,
BP
has
emerged
as
contemporary
effective
approach
addressing
defects.
As
an
vivo
graft,
necessitates
excellent
biocompatibility
appropriate
mechanical
properties.
Furthermore,
it
should
closely
mirror
architecture
functionality
natural
periosteum.
This
review
provides
detailed
summary
recent
research
progress
on
BP,
incorporating
inspiring
studies
that
future
development
this
field.
Initially,
examines
structure
function
context
defect
repair.
Subsequently,
analyzes
current
design
concept
construction
comprehensive
overview
materials
techniques
constructing
BP.
Finally,
summarizes
strategies
used
defects
from
various
perspectives
including
structural
functional
biomimicry,
discusses
latest
advances
research.
Microstructures,
Journal Year:
2025,
Volume and Issue:
5(3)
Published: April 23, 2025
Tissue
damage
poses
a
significant
burden
on
patients’
daily
lives
and
has
long
driven
the
search
for
effective
clinical
treatments.
Recent
decades
have
witnessed
development
of
smart
biomedical
materials
satisfying
specific
requirements
such
as
irregular
shapes
dynamic
microenvironments
at
defective
sites.
Stimuli-responsive
polymeric
films
are
well-positioned
to
play
considerable
role
in
exploitation
next-generation
biomaterials
both
soft
hard
tissue
regeneration.
These
can
be
fabricated
through
diverse
approaches
engineered
with
versatile
structures
properties.
Furthermore,
responsive
stimuli
temperature,
water,
light,
these
exhibit
well-designed
functions
shape
adaption,
controlled
drug
release,
cell
adhesion
vivo
,
effectively
improving
In
this
work,
we
review
recent
advancements
stimuli-responsive
films,
beginning
introduction
their
fabrication
methods.
Subsequently,
mechanisms
discussed
scrutinized
terms
structure
property
variations.
An
overview
applications
regeneration,
including
skin,
cardiovascular,
nerve,
bone
is
provided.
Finally,
further
discuss
benefits
limitations
practical
applications,
proposing
our
expectations
perspectives
future
films.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 26, 2024
Abstract
Poly
(l-lactic
acid)
(PLLA)
is
a
biocompatible,
biodegradable
material
with
piezoelectric
properties,
making
it
promising
candidate
for
providing
self-powered
stimulation
to
accelerate
tissue
repair.
Repairs
various
tissues,
such
as
bone,
cartilage
and
nerve,
necessitate
distinct
characteristics
even
from
the
same
material.
However,
extensive
utilization
of
PLLA
scaffolds
in
hindered
by
their
low
single
constants.
In
this
study,
nanofiber
membranes
enhanced
adjustable
constants
(d33)
were
fabricated
through
oriented
electrospinning.
By
carefully
controlling
parameters
spinning
solution,
steady
increase
d33
values
0
30
pC/N
was
achieved.
This
advancement
allows
tailoring
meet
requirements
different
tissues.
As
an
example
optimal
constants,
we
developed
PLLA-2-0,
PLLA-2-10,
PLLA-2-15
PLLA-2-20
0,
5,
10
15
pC/N,
respectively.
The
impact
varying
on
cellular
behavior
repair
efficacy
validated
vitro
experiments
vivo
mandibular
critical
defect
results
indicated
that
demonstrated
superior
cell
proliferation
rate
up
130%
osteogenic
differentiation
level
approximately
twice
control.
addition,
significantly
promoted
adhesion
migration,
aspect
ratio
about
five
times
higher
than
control
group.
vivo,
restorative
effects
rat
mandibles
via
endogenous
mechanical
force-mediated
stimulation,
leading
complete
histological
restoration
within
8
weeks.
These
findings
highlight
potential
high
straightforward
process.
study
provides
novel
approach
development
highly
electroactive
tailored
specific
needs.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3314 - 3314
Published: Nov. 27, 2024
Biodegradable
piezoelectric
polymers
have
emerged
as
a
hot
research
focus
in
bioelectronics,
energy-harvesting
systems,
and
biomedical
applications,
well
sustainable
future
development.
Biopolymers
possess
plenty
of
features
which
make
them
promising
candidates
for
next-generation
electronic
technologies,
including
biocompatibility,
degradability,
flexibility.
This
review
discusses
biopolymers,
focusing
on
the
relationship
between
coupling
mechanisms,
material
structures,
performance.
Processing
techniques
such
annealing,
mechanical
drawing,
poling
are
introduced
further
studied
terms
achieving
high
work
reviews
strategies
enhancing
properties
via
molecular
engineering,
nano
structuring,
incorporation
additives.
Furthermore,
applications
these
biopolymers
energy
harvesting
biomedicine
provided,
with
discussion
their
potential
degradable
bioelectronic
devices.
There
still
challenges
optimizing
performance
ensuring
stability.
Our
is
expected
to
provide
an
understanding
help
achieve
wider
application
biopolymers.
