Amelioration of radiation cystitis by tetrahedral framework nucleic acid nanostructures functionalized with quercetin DOI
Wei Wang, Ran Yan, Lede Lin

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152736 - 152736

Published: June 1, 2024

Language: Английский

Multi‐Route Administration Delivery System Based on Tetrahedral Framework Nucleic Acids for Alleviating Type I Hypersensitivity Reactions DOI
Wen Chen, Hao Wang,

Yangxue Yao

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Type I hypersensitivity reactions are the most common type of and can cause various symptoms in different body systems. Currently, there is no standard treatment for manifestations at sites. To address this challenge, a nanocomposite named tFNAs‐siRNA‐siRNA (TSS) designed based on tetrahedral framework nucleic acids (tFNAs). It loaded with two siRNAs enter through multi‐route administration. In terms realization siRNAs’ functions, TSS successfully delivers them downregulates expression Gab2 Syk, thereby inhibiting migration release granules to extracellular space RBL‐2H3 cells. Interestingly, also exhibits effect hindering Ca 2+ efflux from mitochondria stabilize energy metabolism. passive cutaneous anaphylaxis allergic rhinitis model, shows excellent anti‐allergic ability, demonstrates an advantage intraperitoneal injection, transdermal, transnasal routes sum, offers new therapeutic strategy multiple symptoms, highlighting application potential acids‐based administration delivery system.

Language: Английский

Citations

0
Natural multi-actives composited hydrogel patches for diabetic wound healing DOI
Youjun Ding,

Xiangyi Wu,

Yi Cheng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153335 - 153335

Published: June 20, 2024

Language: Английский

Citations

3
A Multifunctional Nanocomplex as miRNA/Antibiotic Co‐Delivery System Based on Tetrahedral Framework DNA: Application to Infected Wound Healing DOI
Xiaoying Lyu,

Haoyan Wu,

Ye Chen

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Infected wounds are a complex disease involving bacterial infections and dysregulated inflammation. However, current research has mostly focused on inhibition rather than Thus, combined therapeutic strategies with anti‐bacterial anti‐inflammation efficacies urgently needed. Antibiotics the main treatment strategy for infections. excessive use of antibiotics throughout body can cause serious side effects. In addition, miRNA‐based therapeutics superior wounds, but their rapid degradation poor cellular uptake limit clinical application. Tetrahedral framework DNA (tFNA) is an ideal drug delivery system owing to its excellent stability remarkable transport ability. Herein, novel multi‐functional miRNA antibiotic co‐delivery based tFNA presented first time, called B/L. B/L heightened resistance serum codelivery After transdermal administration, specifically target TNF receptor‐associated factor 6(TRAF6) IL‐1receptor‐associated kinase 1(IRAK1), thereby regulating nuclear kappa‐B (NF‐𝜿B) thus effectively reducing inflammation promoting healing infected wounds. This provides versatile, simple, biocompatible, powerful platform personalized multiple diseases.

Language: Английский

Citations

3
Macrophage membrane coated functionalized nanoparticles for targeted drug delivery and neural function repair in cerebral ischemia–reperfusion injury DOI
Ting Li, Wenzhu Wang, Weijin Liu

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 672, P. 125329 - 125329

Published: Feb. 7, 2025

Language: Английский

Citations

0
Amelioration of radiation cystitis by tetrahedral framework nucleic acid nanostructures functionalized with quercetin DOI
Wei Wang, Ran Yan, Lede Lin

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152736 - 152736

Published: June 1, 2024

Language: Английский

Citations

2