Bortezomib-encapsulated metal–phenolic nanoparticles for intracellular drug delivery DOI Creative Commons

Haidong Zhou,

Hongyu Xu,

Jiaping Man

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(36), P. 26176 - 26182

Published: Jan. 1, 2024

Bortezomib (BTZ) is an important boronate proteasome inhibitor that widely used in cancer therapy. However, the clinical application of BTZ suffers from poor stability and serious adverse effects. Herein, we fabricated metal-polyphenol nanoparticles for covalent encapsulation BTZ. BTZ-encapsulated tannic acid (TA)-Fe

Language: Английский

A polymyxin B loaded hypoxia-responsive liposome with improved biosafety for efficient eradication of bacterial biofilms DOI
Fang Liu, Lingyun Zou, Yongcheng Chen

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(9), P. 8325 - 8336

Published: July 5, 2024

Language: Английский

Citations

1
Targeted Bacterial Keratitis Treatment with Polyethylene Glycol-Dithiothreitol-Boric Acid Hydrogel and Gatifloxacin DOI

Xiao Shen,

Chunlian Huang,

Jianhai Bai

et al.

Current Drug Delivery, Journal Year: 2024, Volume and Issue: 21(11), P. 1548 - 1558

Published: March 1, 2024

Introduction/Objective: To prolong the ocular residence time of gatifloxacin and enhance its efficacy against bacterial keratitis, this study developed a velocity-controlled polyethylene glycol-dithiothreitol-boric acid (PDB) hydrogel loaded with gatifloxacin. Methods: First, basic properties synthesized PDB gatifloxacin-loaded were assessed. Secondly, in vitro degradation rate drug-loaded was measured simulated body fluid environment pH 7.4/5.5. The release behavior studied using dialysis method PBS solution 7.4/5.5 as medium. Finally, mouse model keratitis established, tissue morphology observed hematoxylin-eosin staining. Additionally, tear extracted to observe antibacterial effect hydrogel. Results: results showed that had particle size 124.9 nm zeta potential -23.3 mV, good porosity, thermosensitivity, viscosity distribution, rheological properties, high cell compatibility. encapsulation did not alter physical maintained appropriate swelling stability, drug acidic conditions. Furthermore, animal experiments demonstrated gatifloxacin- exhibited superior therapeutic effects compared eye drops displayed strong capabilities keratitis. Conclusion: This successfully system. responsiveness, excellent biocompatibility, which can retention, utilization, on surface.

Language: Английский

Citations

0
Metal–Polyphenol–Collagen Self-Assembled Bioadhesive with Immune Regulation for Infected Wound Healing DOI

Yeyu Zhao,

Yonggan Yan,

Shulei Xu

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(15), P. 9343 - 9352

Published: July 25, 2024

Destroyed skin barriers for extensive cutaneous wounds often bring about delayed healing and even systemic complications. Multifunctional dressing materials targeting different stages of the process have drawn growing concerns to obtain desirable tissue repair. In this study, a self-assembled collagen/tannic acid–zinc (ColTA-Zn) bioadhesive powder with dual cross-linking network was developed infected wound healing. The hydrogen bonds between collagen chains tannic acid, together metal coordination formed by Zn2+ mainly contribute adhesion performances mechanical properties bioadhesive. Furthermore, biocompatible ColTA-Zn exerts antimicrobial effects on Staphylococcus aureus. Crucially, can absorb blood or exudate quickly along rapid gelation adhere surface once contacting wounds, playing roles adsorption, convergence, adhesion. During process, self-gelled exhibits an immunomodulatory effect macrophage polarization ultimately accelerates Therefore, self-assembled, accessible, user-friendly adhesive might be potential candidate dressings adhesive, anti-infectious, conglutinant functions.

Language: Английский

Citations

0
Copper‐Polyphenol Nanocomplexes with Peroxidase‐Like Activity for Enhanced Fungal Eradication DOI
Fang Liu, Yongcheng Chen, Yi Huang

et al.

ChemCatChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract The increasing severity of fungal infections globally and the limited availability effective treatments necessitate novel therapeutic strategies. In this study, we prepared copper‐polyphenol nanocomplexes (CPE NPs) through a one‐step synthetic process by coordination self‐assembly copper sulfate (CuSO 4 ), protocatechuic acid (PA), ϵ‐poly‐L‐lysine (EPL). CPE NPs demonstrated peroxidase‐like activities, which could catalyze H 2 O to generate hydroxyl radicals (⋅OH) effectively eradicate fungi. were stable in physiological neutral environment. However, since metal‐phenolic interaction was unstable acidic pH, be dissociated environments, such as infection sites, leading release Cu 2+ EPL, thereby exerting antifungal effects. exhibited excellent fungicidal ability at both pH 7.4 6.0 against Candida albicans Aspergillus flavus . More importantly, fungi 20 % Sabouraud dextrose broth (SDB) medium containing rich inorganic salts proteins, dissociative completely lost its ability. summary, deliver surface for enhanced eradication generating ⋅OH, highlighting their great potential promising nano‐therapeutic agent treatment infections.

Language: Английский

Citations

0
Bortezomib-encapsulated metal–phenolic nanoparticles for intracellular drug delivery DOI Creative Commons

Haidong Zhou,

Hongyu Xu,

Jiaping Man

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(36), P. 26176 - 26182

Published: Jan. 1, 2024

Bortezomib (BTZ) is an important boronate proteasome inhibitor that widely used in cancer therapy. However, the clinical application of BTZ suffers from poor stability and serious adverse effects. Herein, we fabricated metal-polyphenol nanoparticles for covalent encapsulation BTZ. BTZ-encapsulated tannic acid (TA)-Fe

Language: Английский

Citations

0