Manganese Empowered Electronic Modulated Nanocatalysts Facilitate Bone Reconstruction via Osteoclastogenesis Inhibition and Osteogenesis Activation Bistimulatory Strategy

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112364 - 112364

Published: March 1, 2025

Language: Английский

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3D-printed bioceramic scaffolds for bone defect repair: bone aging and immune regulation

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

The management of bone defects, particularly in aging populations, remains a major clinical challenge. immune microenvironment plays an important role the repair defects and favorable environment can effectively promote defects. However, is closely associated with chronic low-grade systemic inflammation, which adversely affects healing. Persistent inflammation critically regulates through all stages. This review explores potential 3D-printed bioceramic scaffolds defect repair, focusing on their capacity to modulate counteract effects aging. not only provide structural support for regeneration but also serve as effective carriers anti-osteoporosis drugs, offering novel therapeutic strategy treating osteoporotic By regulating improving response, may significantly enhance context age-related degeneration. approach underscores advanced biomaterials addressing dual challenges dysregulation, promising avenues development treatments elderly. We hope concepts discussed this could offer strategies suggest future optimization scaffolds.

Language: Английский

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Intelligent Nanomaterials Design for Osteoarthritis Managements

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Language: Английский

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Engineered Pseudomonas mirabilis-Derived Outer Membrane Vesicles Targeting Bone Microenvironment to Improve Osteoporosis

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 847 - 847

Published: April 2, 2025

Introduction: Osteoporosis (OP) is a prevalent condition marked by reduced bone density and heightened risk of fractures. Current treatments often have side effects, underscoring the need for safer alternatives. Recent research highlights significant role gut microbiota their metabolites in maintaining health. Notably, bacterial outer membrane vesicles (OMVs) emerged as promising platform due to nanoscale sizes, low toxicity, drug-loading capabilities, excellent biocompatibility. Methods: In this study, we developed delivery system using OMVs derived from Pseudomonas mirabilis (PM). By anchoring bone-targeting peptides PM-OMVs membrane, equipped these deliver endogenous miRNAs microenvironment effectively. Results Discussion: The bone-targeted (PM-OMVs-BT) demonstrated exceptional abilities exhibited favorable safety profile vivo. Additionally, LGG-OMVs-BT were successfully internalized marrow stromal cells (BMSCs) without cytotoxicity, effectively promoting osteogenic differentiation mineralization. conclusion, our study indicates that PM-OMVs-BT could offer safe effective treatment option OP.

Language: Английский

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Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract As an enticing bone anabolic target, short‐term inhibition of Schnurri‐3 (SHN3) resulted in high‐bone mass due to augmented osteoblast activity. However, no studies are conducted identify natural products targeting SHN3 inhibition. Herein, a screening strategy for the discovery marine compounds that facilitate differentiation by silencing is presented. One leading quinolinone alkaloid, viridicatol (VDC), isolated from deep‐sea‐derived fungus, vigorously promotes osteogenic via Wnt/SHN3 signaling pathway osteoblasts, thereby preventing osteoporosis while enhancing bone‐fracture healing mouse model. Subsequently, SDSSD (Ser, Asp, Ser, Asp) further employed engineer bone‐targeting nanovesicles (BT‐NVs) optimal delivery VDC which mitigates loss observed severe osteogenesis imperfecta Hence, these results initially uncover promising product, VDC, treatment and highlighting its translational potential clinical applications.

Language: Английский

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Nanomaterials‐Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract The etiology of osteoporosis is rooted in the disruption intricate equilibrium between bone formation and resorption processes. Nevertheless, conventional anti‐osteoporotic medications hormonal therapeutic regimens currently employed clinical practice are associated with a multitude adverse effects, thereby constraining their overall efficacy potential. Recently, nanomaterials have emerged as promising alternative due to minimal side efficient drug delivery, ability enhance formation, aiding restoring balance. This review delves into fundamental principles remodeling microenvironment, well current treatment approaches for osteoporosis. It subsequently explores research status nanomaterial‐based delivery systems treatment, encompassing inorganic nanomaterials, organic cell‐mimicking carriers exosomes mimics emerging therapies targeting microenvironment. Finally, discusses potential nanomedicine treating outlines future trajectory this burgeoning field. aim provide comprehensive reference application strategies therapy, fostering further advancements innovations critical area medical

Language: Английский

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Injectable Gypsogenin‐Based Composite Hydrogel Enhances Osteoporotic Bone Regeneration by Alleviating Oxidative Injury via Promoting AMPKα Phosphorylation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Osteoporosis is characterized by an imbalance between osteoblasts and osteoclasts coupling excessive oxidative stress in the bone microenvironment that impairs defect healing increases risk of non‐union. In this study, injectable gypsogenin (GN)‐based organic–inorganic composite hydrogel (CCT/nHA@GN) developed to treat osteoporotic defects. The made grafting sodium citrate (SC) nano‐hydroxyapatite (nHA)/GN nanoparticles onto carboxymethylated chitosan (CMCS). GN a natural small‐molecule saponin, which shows biocompatibility anti‐oxidant properties. resulting well‐defined porous structure, favorable degradability, controlled drug‐release properties, suitable rheological characteristics. Importantly, it reverses differentiation fate marrow‐derived mesenchymal stem cells (BMSCs) from patients promotes angiogenesis human umbilical vein endothelial (HUVECs). Furthermore, activates AMPKα‐FOXO3a‐CAT/MnSOD signaling pathway via AMPKα phosphorylation, thereby augmenting antioxidant capacity, promoting osteogenesis, inhibiting osteoclastogenesis, ultimately rectifying disrupted microenvironment. vivo studies reveal volume total (BV/TV) ratio bones regenerated with CCT/nHA@GN 2.85 times higher than control group. conclusion, these findings suggest can be promising alternative material for treatment

Language: Английский

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Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101789 - 101789

Published: April 22, 2025

Periodontitis is characterized by inflammation and alveolar bone loss, primarily caused immune cells activated oral bacteria, leading to an imbalance between osteogenesis resorption. Traditional treatments have limited efficacy, which has led the exploration of regulating microenvironment utilizing tissue engineering methods as new research directions. Our study demonstrates that macrophage membranes, LPS IFN-γ, can effectively neutralize inflammatory factors. By coating poly-L-lysine (PLL) modified poly (lactic-co-glycolic acid) (PLGA)/β-TCP microspheres with such membrane vesicles, MM@PPT regulate intercellular responses inhibiting M1 polarization osteoclast differentiation, promoting M2 polarization, enhancing osteogenic differentiation marrow stromal (BMSCs) even in environment. injecting into sites periodontitis induced resorption, it found they promote regeneration modulating immune-regeneration microenvironment. This work not only highlights potential but also provides insights how these modulate cell behavior interactions. The findings this offer novel therapeutic strategies for repair periodontitis.

Language: Английский

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The Correlations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Bone Mineral Density in Postmenopausal Women: A Cross-Sectional Study

Osteology, Journal Year: 2025, Volume and Issue: 5(2), P. 14 - 14

Published: May 6, 2025

Background/Objectives: Osteoporosis is a skeletal disorder characterized by reduced bone mineral density (BMD) and increased fracture risk. Chronic inflammation implicated in osteoporosis pathogenesis, with inflammatory mediators promoting resorption. The neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) are markers of systemic have emerged as potential indicators health. This study’s aim was to highlight the role NLR PLR health postmenopausal women affected or osteopenia evaluate possible influence autoimmune disease this context. Methods: cross-sectional study included 124 diagnosed at Orthopedic Unit Policlinico G. Rodolico Catania, Italy. Demographic, clinical, laboratory, diagnostic imaging data were collected. calculated from complete blood counts, BMD measured using dual-energy X-ray absorptiometry (DEXA). Statistical analyses correlations, group comparisons, multiple logistic regressions. Results: did not directly correlate incidence. However, weakly correlated vitamin D levels. Notably, without Hashimoto’s thyroiditis exhibited higher values than those condition. Hypertensive had lower non-hypertensive women, while euthyroid hyperthyroid hypothyroid women. Multiple regression analysis revealed that age, BMI, CKD stage, levels, NLR, PLR, diabetes, diseases significantly predicted femur neck, contributing significantly. Logistic confirmed these predictors for osteopenia, an being associated likelihood osteoporosis. Conclusions: While may independently predict health, their inclusion multifactorial assessment considering D, comorbidities could enhance management.

Language: Английский

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Leveraging Nanoscience and Strategic Delivery for the Expedition of Osteoporosis

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: May 8, 2025

Language: Английский

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