Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1177 - 1192
Published: Dec. 1, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(42)
Published: June 27, 2024
Acute myeloid leukemia (AML) is a common and catastrophic hematological neoplasm with high mortality rates. Conventional therapies, including chemotherapy, hematopoietic stem cell transplantation (HSCT), immune therapy, targeted agents, have unsatisfactory outcomes for AML patients due to drug toxicity, off-target effects, resistance, side relapse refractoriness. These intrinsic limitations of current treatments promoted the development application nanomedicine more effective safer therapy. In this review, classification nanoparticles applied in liposomes, polymersomes, micelles, dendrimers, inorganic nanoparticles, reviewed. addition, various strategies enhancing therapeutic targetability nanomedicine, use conjugating ligands, biomimetic-nanotechnology, bone marrow targeting, which indicates potential reverse are discussed. The assisting immunotherapy also involved. Finally, advantages possible challenges transition from preclinical phase clinical
Language: Английский
Citations
5
Smart Medicine, Journal Year: 2023, Volume and Issue: 2(4)
Published: Nov. 1, 2023
Abstract Circulating tumor DNA (ctDNA) is naked molecules shed from the cells into peripheral blood circulation. They contain tumor‐specific gene mutations and other valuable information. ctDNA considered to be one of most significant analytes in liquid biopsies. Over past decades, numerous researchers have developed various detection strategies perform quantitative or qualitative analysis, including PCR‐based sequencing‐based detection. More more studies illustrated great value as a biomarker diagnosis, prognosis heterogeneity tumor. In this review, we first outlined development digital PCR (dPCR)‐based next generation sequencing (NGS)‐based systems. Besides, presented introduction emerging analysis based on biosensors, such electrochemical fluorescent surface plasmon resonance Raman spectroscopy, well their applications field biomedicine. Finally, summarized essentials preceding discussions, existing challenges prospects for future are also involved.
Language: Английский
Citations
12
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 37, P. 101997 - 101997
Published: March 23, 2024
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131722 - 131722
Published: April 21, 2024
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Cyclophosphamide has a certain therapeutic effect on treating systemic sclerosis (SSc), while difficulties exist in controlling severe systematic side effects and enhancing targeting capacity. Here, inspired from the natural extracellular matrix composition, we propose cyclophosphamide-encapsulated nanogel based dendritic polymers polyamidoamine (PAMAM) for SSc treatment. We combine bovine serum albumin generation 5 (G5) PAMAM dendrimers with polyphenol modification to obtain nanogels featured antioxidant anti-inflammatory effects. The can possess excellent biocompatibility prevent fibroblasts oxidative stress damage TGF-β-mediated activation. Furthermore, bleomycin-induced mouse model, dendrimer encapsulating cyclophosphamide also exhibit ability attenuate fibrosis by modulating immunity, suppressing inflammation, reducing collagen synthesis. These findings underscore value of this polymer treatment chronic SSc, indicating its broader potential clinical applications.
Language: Английский
Citations
0
Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract Polymeric nanoarchitectures are crafted from amphiphilic block copolymers through a meticulous self‐assembly process. The composition of these is finely adjustable, bestowing precise control over the characteristics and properties resultant polymeric assemblies. These nanoparticles have garnered significant attention, particularly in realm biological sciences, owing to their biocompatibility, favorable pharmacokinetics, facile chemically modifiable nature. Among myriad nanoarchitectures, micelles polymersomes stand out as frontrunners, exhibiting much potential cargo carrier systems for diverse bio‐applications. This review elucidates design strategies employed assemblies, specifically focusing on polymersomes. Subsequently, it discusses wide‐ranging bio‐applications, spanning drug delivery diagnostics bioimaging artificial cell applications. Finally, reflective analysis will be provided, highlighting current landscape carriers, discussing opportunities challenges that lie ahead. With this review, aimed summarize recent advances assemblies applications biomedical field.
Language: Английский
Citations
0
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 503 - 523
Published: Feb. 11, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101583 - 101583
Published: Feb. 16, 2025
The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like imprecise delivery, poor bioavailability, high dose requirement, and tendency develop multidrug resistance. With protection NCs, drugs can reach lesion site then release accurately completely. Although some reviews have summarized biological applications little attention has been given advantages disadvantages analyzing organic, inorganic, hybrid NCs separately for targeted therapy identifying means further improve targeting ability. First, in this review, we emphasize three factors that marked impact on therapy: tumor microenvironment (TME), different administration modalities (intravenous, oral, intracavitary administration), pathways (passive active). Second, systematic examination polymeric dendrimers, micelles, liposomes, mesoporous silica gold quantum dots, nano clay, core-shell MOFs are reviewed. Further, propose ways efficiency therapy, including regulating size, shape, surface properties NCs.
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Multivalency enables interactions with higher affinities and specificities than monovalent interactions. The strategy exploited by nature to modulate biorecognition has inspired the design of multivalent conjugates therapeutic properties. However, chemical functionalization often requires coupling agents, additives, or metal catalysts that complicate isolation purification. Herein, azide–alkyne cycloaddition (AAC) alkynyl dicarbamates (Alk-R) is presented as a flexible, reliable, atom-economical, user-friendly for polymeric scaffolds. Alk-R functionalized biologically relevant ligands have been prepared used AAC azide-bearing dendrimers block copolymers. resulting polymers double multivalency reveal platform development bioinspired functional systems promising applications in drug delivery: copolymer micelles multifunctional nanocarriers synergistically integrated probes-ligands-drugs. extension this other scaffolds expected open up wide range diagnostic opportunities.
Language: Английский
Citations
0