International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13540 - 13540
Published: Dec. 18, 2024
Gene
transfection
is
a
fundamental
technique
in
the
fields
of
biological
research
and
therapeutic
innovation.
Due
to
their
biocompatibility
membrane-mimetic
properties,
lipid
vectors
serve
as
essential
tools
transfection.
The
successful
delivery
genetic
material
into
cytoplasm
contingent
upon
fusion
vector
cellular
membranes,
which
enables
hydrophilic
polynucleic
acids
traverse
hydrophobic
barriers
two
intervening
membranes.
This
review
examines
critical
role
membrane
lipofection
efficiency,
with
particular
focus
on
molecular
mechanisms
that
govern
lipoplex–membrane
interactions.
analysis
will
examine
key
challenges
inherent
process,
from
achieving
initial
proximity
facilitating
final
content
release
through
remodeling.
In
contrast
viral
vectors,
utilize
specialized
proteins,
necessitate
strategic
formulation
environmental
optimization
enhance
fusogenicity.
discusses
recent
advances
design
fusion-promoting
strategies,
emphasizing
potential
improve
gene
yield.
It
highlights
importance
understanding
for
developing
next-generation
systems
emphasizes
need
continued
advance
lipid-mediated
technology.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(6), P. 624 - 634
Published: April 23, 2024
Scientific
knowledge
of
cancer
has
advanced
greatly
throughout
the
years,
with
most
recent
studies
findings
includes
many
hallmarks
that
capture
disease's
multifaceted
character.
One
novel
approach
utilized
for
delivery
anti-cancer
agents
mesenchymal
stem
cell
mediated
drug
delivery.
Mesenchymal
cells
(MSCs)
are
non-hematopoietic
progenitor
may
be
extracted
from
bone
marrow,
tooth
pulp,
adipose
tissue
and
placenta/umbilical
cord
blood
dealing
adult
cells.
MSCs
mostly
involved
in
regeneration
tissue,
they
have
also
been
shown
to
preferentially
migrate
location
several
types
tumor
in-vivo.
Usage
ought
improve
both
effectiveness
safety
drugs
by
enhancing
efficiency
therapies
site.
Numerous
researches
demonstrated
various
drugs,
when
delivered
via
can
elicit
anti-tumor
effect
cancers
breast
thyroid
minimal
immunogenicity
because
lack
co-stimulatory
molecule
expression,
which
means
there
is
no
requirement
immunosuppression
after
allogenic
transplantation.
This
current
review
elaborates
advancements
mesenchyma
along
its
mechanism
previously
reported
manufactured
this
system.
The
construction
of
cell
mimics
replicating
the
surface
landscape
and
biological
functions
membrane
offers
promising
prospects
for
biomedical
research
applications.
Inspired
by
inherent
recognition
capability
immune
cells
toward
pathogens,
we
have
fabricated
activated
macrophage
membrane-coated
magnetic
silicon
nanoparticles
(aM-MSNPs)
in
this
work
as
an
isolation
tool
enhanced
bacterial
analysis.
Specifically,
natural
protein
receptors
on
endow
MSNPs
with
a
broad-spectrum
binding
capacity
to
different
pathogen
species.
By
further
incorporation
tyramide
amplification
strategy,
direct
naked-eye
analysis
specific
bacteria
detection
limit
10
CFU/mL
can
be
achieved.
Moreover,
application
diagnosis
urinary
tract
infections
has
also
been
validated,
positive
samples
spiked
clearly
distinguished
accuracy
100%.
This
may
enrich
membrane-based
architectures
provide
experimental
paradigm
point-of-care
testing
(POCT)
bacteria.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 27, 2024
Abstract
Corneal
neovascularization
(CNV)
is
one
of
the
common
blinding
factors
worldwide,
leading
to
reduced
vision
or
even
blindness.
However,
current
treatments
such
as
surgical
intervention
and
anti-VEGF
agent
therapy
still
have
some
shortcomings
evoke
adverse
effects.
Recently,
SU6668,
an
inhibitor
targeting
angiogenic
tyrosine
kinases,
has
demonstrated
growth
inhibition
neovascularization.
But
hydrophobicity
low
ocular
bioavailability
limit
its
application
in
cornea.
Hereby,
we
proposed
preparation
SU6668
pure
nanoparticles
(NanoSU6668;
size
~135
nm)
using
a
super-stable
pure-nanomedicine
formulation
technology
(SPFT),
which
possessed
uniform
particle
excellent
aqueous
dispersion
at
1
mg/mL.
Furthermore,
mesenchymal
stem
cell
membrane
vesicle
(MSCm)
was
coated
on
surface
NanoSU6668,
then
conjugated
with
TAT
penetrating
peptide,
preparing
multifunctional
TAT-MSCm@NanoSU6668
(T-MNS).
The
T-MNS
concentration
200
µg/mL
treated
for
CNV
via
eye
drops,
accumulated
blood
vessels
high
performance,
resulting
elimination
recovery
cornea
transparency
after
4
days
treatment.
Meanwhile,
drug
safety
test
confirmed
that
did
not
cause
any
damage
cornea,
retina
other
tissues.
In
conclusion,
drop
had
potential
treat
effectively
safely
dosing
frequency,
broke
new
ground
theranostics.
Small,
Journal Year:
2024,
Volume and Issue:
20(47)
Published: Aug. 17, 2024
Conventional
drug
delivery
techniques
face
challenges
related
to
targeting
and
adverse
reactions.
Recent
years
have
witnessed
significant
advancements
in
nanoparticle-based
carriers.
Nevertheless,
concerns
persist
regarding
their
safety
insufficient
metabolism.
Employing
cells
derivatives,
such
as
cell
membranes
extracellular
vesicles
(EVs),
carriers
effectively
addresses
the
associated
with
nanoparticle
However,
an
essential
hurdle
remains
efficiently
loading
drugs
into
these
With
advancement
of
microfluidic
technology
its
advantages
precise
manipulation
at
micro-
nanoscales,
well
minimal
sample
loss,
it
has
found
extensive
application
using
thereby
fostering
development
drug-loading
techniques.
This
paper
outlines
characteristics
benefits
utilizing
derivatives
provides
overview
current
techniques,
particularly
those
rooted
technology.
The
potential
for
targeted
disease
therapy
through
systems
employing
is
foreseen.
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Journal Year:
2024,
Volume and Issue:
32(3), P. 433 - 437
Published: Jan. 1, 2024
The
main
aim
of
antineoplastic
treatment
is
to
maximize
patient
benefit
by
augmenting
the
drug
accumulation
within
affected
organs
and
tissues,
thus
incrementing
effects
and,
at
same
time,
reducing
damage
non-involved
tissues
cytotoxic
agents.
Mesenchymal
stromal
cells
(MSC)
represent
a
group
undifferentiated
multipotent
presenting
wide
self-renewal
features
capacity
differentiate
into
an
assortment
mesenchymal
family
cells.
During
last
year,
they
have
been
proposed
as
natural
carriers
for
selective
release
antitumor
drugs
malignant
cells,
optimizing
action
on
cancer
while
significantly
adverse
side
healthy
MSC
chemotherapeutic
loading
delivery
encouraging
new
area
cell
therapy
several
tumors,
especially
those
with
unsatisfactory
prognosis
limited
options
available.
Although
some
experimental
models
successfully
developed,
phase
I
clinical
studies
are
needed
confirm
this
potential
application
therapy,
in
particular
case
primary
secondary
lung
cancers.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13540 - 13540
Published: Dec. 18, 2024
Gene
transfection
is
a
fundamental
technique
in
the
fields
of
biological
research
and
therapeutic
innovation.
Due
to
their
biocompatibility
membrane-mimetic
properties,
lipid
vectors
serve
as
essential
tools
transfection.
The
successful
delivery
genetic
material
into
cytoplasm
contingent
upon
fusion
vector
cellular
membranes,
which
enables
hydrophilic
polynucleic
acids
traverse
hydrophobic
barriers
two
intervening
membranes.
This
review
examines
critical
role
membrane
lipofection
efficiency,
with
particular
focus
on
molecular
mechanisms
that
govern
lipoplex–membrane
interactions.
analysis
will
examine
key
challenges
inherent
process,
from
achieving
initial
proximity
facilitating
final
content
release
through
remodeling.
In
contrast
viral
vectors,
utilize
specialized
proteins,
necessitate
strategic
formulation
environmental
optimization
enhance
fusogenicity.
discusses
recent
advances
design
fusion-promoting
strategies,
emphasizing
potential
improve
gene
yield.
It
highlights
importance
understanding
for
developing
next-generation
systems
emphasizes
need
continued
advance
lipid-mediated
technology.
