ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(37)
Published: Sept. 27, 2024
Abstract
The
aim
of
this
study
was
to
develop
a
new
nicotine
transdermal
patch:
S‐(‐)‐Nicotine‐loaded
nano
flexible
liposome
hydrogel
patch
(S‐(‐)‐Nicotine‐NFL‐HGP),
which
combined
and
achieve
the
long‐lasting
sustained
release
S‐(‐)‐Nicotine
for
treatment
withdrawal
syndrome
(NWS).
nanoscale
liposomes
(S‐(‐)‐Nicotine‐NFL)
were
prepared
using
thin
film
hydration
method,
then
with
three‐dimensional
structured
prepare
S‐(‐)‐Nicotine‐NFL‐HGP.
initial
bond
strength
(IBS)
(18
±
2)
s,
lasting
(EBS)
(23.5
3.4)
appearance
pale
yellow.
cumulative
rate
64.8%
within
48
h
Higuchi
equation
drug
process
y
=
9.47x
1/2
−1.13
(
R
2
0.99412).
transmittance
per
unit
area
after
(1047
25.0)
µg/cm
dermal
retention
(35.1
4.2)
.
showed
highest
fit
in
experiments
S‐(‐)‐Nicotine.
Stability
results
that
IBS,
EBS,
appearance,
performance
almost
unchanged
90
days,
had
excellent
stability.
has
potential
application
prospects.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Hydrogel
microspheres
are
important
in
regenerative
medicine
and
tissue
engineering,
acting
as
cargos
of
cells,
drugs,
growth
factors,
bio‐inks
for
3D
printing,
medical
devices.
The
antimicrobial
anti‐inflammatory
characteristics
hydrogel
good
treating
injured
tissues.
However,
the
biological
properties
should
be
modified
optimal
treatment
various
body
parts
with
different
physiological
biochemical
environments.
In
addition,
specific
preparation
methods
required
to
produce
customized
shapes
sizes
clinical
applications.
Herein,
advances
biomedical
applications
reviewed.
Synthesis
precursor
solutions,
manufacturing
methods,
strategies
enhancing
functions
these
described.
involvement
bioactive
repair
is
also
discussed.
This
review
anticipates
fostering
more
insights
into
design,
production,
application
biomedicine.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Osteoporosis
(OP)
is
a
systemic
disease
characterized
by
decreased
bone
density
and
quality,
leading
to
fragile
bones
osteoporotic
fractures
(OPF).
Conventional
treatments
for
OPF
often
exhibit
limited
therapeutic
efficacy
significant
side
effects.
Synthetic
biology-based
bacterial
extracellular
vesicles
(BEVs)
offer
safe
effective
alternative
treatment.
Here,
we
constructed
bioengineered
BEVs
loaded
with
pBMP-2-VEGF
(BEVs-BP)
encapsulated
them
together
IL-4
in
GelMA
hydrogels
form
IL-4/BEVs-BP@GelMA.
Initially,
alleviated
chronic
inflammation
modulating
immune
cells,
while
BEVs-BP
subsequently
enhanced
osteogenesis
vascularization
upregulating
BMP-2
VEGF
expression.
In
vitro,
IL-4/BEVs-BP@GelMA
polarized
M1
macrophages
toward
the
M2
phenotype,
osteogenesis,
increased
angiogenesis.
Moreover,
effectively
promoted
maturation
mineralization
of
organoids
vivo.
Finally,
successfully
accelerated
fracture
repair
mice.
summary,
developed
an
easy-to-build
powerful
biomaterial,
IL-4/BEVs-BP@GelMA,
which
offers
strategy
management.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
266, P. 130998 - 130998
Published: March 22, 2024
Although
calcium‑magnesium
phosphate
cements
(CMPCs)
have
been
widely
applied
to
treating
critical-size
bone
defects,
their
repair
efficiency
is
unsatisfactory
owing
weak
surface
bioactivity
and
uncontrolled
ion
release.
In
this
study,
we
lyophilized
alginate
sodium
(AS)
as
a
coating
for
HAp/K-struvite
(H@KSv)
develop
AS/HAp/K-struvite
(AH@KSv),
which
promotes
regeneration.
The
compressive
strength
hydrophilicity
of
AH@KSv
significantly
improved,
leading
enhanced
cell
adhesion
in
vitro.
Importantly,
the
SA
enables
continuous
ions
release
Mg2+
Ca2+,
finally
osteogenesis
vitro/vivo
different
patterns
new
growth
vivo.
Furthermore,
these
composites
increased
expression
levels
biomarkers
TRPM7/PI3K/Akt
signaling
pathway
via
an
equilibrium
effect
Ca2+.
conclusion,
our
study
provides
novel
insights
into
mechanisms
Mg-based
biomaterials
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Exosomes
are
nano-sized
extracellular
vesicles
(EVs)
released
by
diverse
types
of
cells,
which
affect
the
functions
targeted
cells
transporting
bioactive
substances.
As
main
component
exosomes,
non-coding
RNA
(ncRNA)
is
demonstrated
to
impact
multiple
pathways
participating
in
bone
healing.
Herein,
this
review
first
introduces
biogenesis
and
secretion
elucidates
role
cargo
ncRNAs,
mediating
intercellular
communication.
Subsequently,
potential
molecular
mechanism
exosomes
accelerating
healing
elucidated
from
following
four
aspects:
macrophage
polarization,
vascularization,
osteogenesis
osteoclastogenesis.
Then,
we
systematically
introduce
construction
strategies
based
on
modified
regeneration
field.
Finally,
clinical
trials
for
challenges
exosome-based
therapies
biomedical
field
briefly
introduced,
providing
solid
theoretical
frameworks
optimization
methods
application
orthopedics.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Regeneration
of
oral
craniofacial
bone
defects
is
a
complex
process,
and
reconstruction
large
without
the
use
exogenous
cells
or
bioactive
substances
remains
major
challenge.
Hydrogels
are
highly
hydrophilic
polymer
networks
with
potential
to
promote
tissue
regeneration.
In
this
study,
functional
peptide
Dentonin
was
loaded
onto
self-assembled
hydrogels
(RAD)
constitute
functionally
self-assembling
RAD/Dentonin
hydrogel
scaffolds
view
that
could
facilitate
vascularized
regeneration
in
critical-size
calvarial
defects.
The
functionalized
forms
ordered
β-sheet
supramolecular
structures
via
non-covalent
interactions
like
hydrogen
bonding,
ultimately
assembling
into
nano-fiber
network.
exhibited
desirable
porosity
swelling
properties,
appropriate
biodegradability.
supported
adhesion,
proliferation
three-dimensional
migration
marrow
mesenchymal
stem
(BMSCs)
has
induce
differentiation
BMSCs
towards
osteogenesis
through
activation
Wnt/β-catenin
pathway.
Moreover,
modulated
paracrine
secretion
increased
migration,
tube
formation
angiogenic
gene
expression
human
umbilical
vein
endothelial
(HUVECs),
which
boosted
capacity
HUVECs.
vivo,
significantly
strengthened
rat
defect.
Taken
together,
these
results
indicated
effectively
enhance
osteogenic
BMSCs,
indirectly
effects
HUVECs,
vivo.
Thus,
it
promising
material
for
maxillofacial
