Tumor microenvironment-responsive macrophage-mediated immunotherapeutic drug delivery DOI
Xueyang Zhang, Ludan Yue, Lei Cao

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 186, P. 369 - 382

Published: Aug. 2, 2024

Language: Английский

Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance DOI
Zhijie Xu,

Zhou Hai-yan,

Tongfei Li

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 75, P. 101098 - 101098

Published: June 1, 2024

Language: Английский

Citations

10
Exploring the immuno-nano nexus: A paradigm shift in tumor vaccines DOI Open Access
Yuanyuan Li, Yuxing Xu,

Wenwen Su

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897

Published: Feb. 7, 2025

Language: Английский

Citations

1
Dual quenching ECL strategy based on AgInZnS quantum dots and a new co-reaction promoter oxygen vacancy-modified P5AIn/TiO2 for sensitive CEA detection DOI
Qinghua Gong, Yanting Guo, Xianhong Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136844 - 136844

Published: Oct. 1, 2024

Language: Английский

Citations

5
A polyvalent vaccine for selectively killing tumor-associated bacteria to prevent cancer metastasis DOI Creative Commons

Zheyu Kang,

Linfu Chen,

P. li

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(11)

Published: March 14, 2025

Specific bacteria, including Fusobacterium nucleatum , Streptococcus sanguis Enterococcus faecalis and Staphylococcus xylosus have been identified as contributors to breast cancer metastasis. Due limitations such lack of selectivity, traditional antibiotic therapies face obstacles in eliminating intratumoral bacteria. Herein, this work proposes the use therapeutic vaccines selectively target eliminate harmful bacteria within tumors. A multivalent vaccine encapsulating both insoluble soluble bacterial antigens was developed, addressing shortcomings antibacterial by balancing broad antigen coverage with effective immune activation. This induces robust downstream responses F. S. E. demonstrating notable preventive efficacy bacteria-induced metastasis models. Unexpectedly, vaccinated infected mice showed even slower tumor than uninfected mice. Overall, study validates potential nanovaccines modulating microbiome for therapy highlights tumor-associated infections promising antitumor targets.

Language: Английский

Citations

0
Tumor microenvironment-responsive macrophage-mediated immunotherapeutic drug delivery DOI
Xueyang Zhang, Ludan Yue, Lei Cao

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 186, P. 369 - 382

Published: Aug. 2, 2024

Language: Английский

Citations

3