Reactive Oxygen Species-Responsive Nanoparticle Delivery of Small Interfering Ribonucleic Acid Targeting Olfactory Receptor 2 for Atherosclerosis Theranostics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23599 - 23614

Published: Aug. 14, 2024

Atherosclerosis (AS) is a chronic inflammatory disorder characterized by arterial intimal lipid plaques. Small interfering ribonucleic acid (siRNA)-based therapies, with their ability to suppress specific genes high targeting precision and minimal side effects, have shown great potential for AS treatment. However, targets of siRNA therapies based on macrophages treatment are still limited. Olfactory receptor 2 (Olfr2), target plaque formation, was discovered recently. Herein, anti-Olfr2 (si-Olfr2) designed, the theranostic platform encapsulating si-Olfr2 within atherosclerotic lesions also developed, aim downregulating Olfr2, as well diagnosing through photoacoustic imaging (PAI) in second near-infrared (NIR-II) window resolution. By utilization reactive oxygen species (ROS)-responsive nanocarrier system, expression Olfr2 plaques effectively downregulated, leading inhibition NLR family pyrin domain containing 3 (NLRP3) inflammasome activation interleukin-1 β (IL-1β) secretion, thereby reducing formation As manifested decreased expression, exhibited significantly alleviated response that led reduced deposition, macrophage apoptosis, noticeable decrease necrotic areas. This study provides proof concept evaluating nanoplatform specifically deliver lesional diagnosis

Language: Английский

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Enhanced NIR-II Photoacoustic Imaging Performance of Donor-Acceptor Semiconducting Polymers Enabled by Donor Conjugation Extension

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112628 - 112628

Published: Jan. 1, 2025

Language: Английский

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Copper(II)-Complexed Polyethylenimine-Entrapped Gold Nanoparticles Enable Targeted CT/MR Imaging and Chemodynamic Therapy of Tumors

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 423 - 423

Published: Feb. 6, 2025

Transition-metal ion copper(II) (Cu(II)) has drawn increasing attention as a small-molecular cancer theranostic agent. However, delivering sufficient dosage of Cu(II) to the tumor site and integrating multiple imaging modalities achieve precise effective theranostics remains critical challenge. Herein, an emerging Cu(II)-based nanocomposite been synthesized for targeted computed tomography (CT)/magnetic resonance (MR) dual-mode chemodynamic therapy (CDT). Briefly, 2-picolinic acid (PA-COOH), polyethylene glycol (PEG)-linked folic (FA), fluorescein isothiocyanate (FI) were sequentially conjugated with polyethylenimine (PEI.NH2) then in situ fabrication gold nanoparticles (Au NPs) occurred within PEI.NH2 internal cavity. After acetylation terminal amines complexation, nanocomposites FA-Au/Cu(II) PENPs mean diameter 2.87 nm generated. The showed favorable stability colloidal dispersion, sustainable release properties pH-dependent manner, Fenton-like catalytic activity specifically. With FA-mediated targeting pathway, can specifically accumulate cells high expression FA receptors. Meanwhile, complementary CT/MR vitro vivo be afforded by based on excellent X-ray attenuation Au NPs applicable r1 relaxivity (0.7378 mM−1s−1) Cu(II). Notably, Cu(II)-mediated CDT mechanism enables elicit generation toxic hydroxyl radicals (·OH), depletion glutathione (GSH), promotion lipid peroxidation (LPO), induction cell apoptosis vitro, further demonstrates remarkable anti-tumor efficacy xenograft model. illustrated capacity towards tumors, this paradigm inspires construction advanced nanoplatforms incorporating alternative transition metal ions.

Language: Английский

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Exceptional Near-Infrared II Organic Small Molecule Nanoagent for Photoacoustic/Photothermal Imaging-Guided Highly Efficient Therapy in Cancer

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Near-infrared II (NIR-II) photoacoustic (PA)/photothermal imaging-guided tumor therapy holds great promise in precision medicine for cancer treatment. This work reports on the synthesis and application of an organic small molecule nanoagent that has exceptional PA photothermal properties near-infrared region. BCy-TPE was constructed by linking NIR-II absorbing cyanine dye BCy-Cl with a twisted tetraphenylethene unit. The synthesized exhibited intense absorption peak at 1032 nm. After encapsulation into water-dispersible nanoparticles (NPs), NPs two peaks 880 1046 Notably, under 1064 nm laser excitation, deliver remarkable conversion efficiency 92%, together superior biocompatibility, photostability, PA/photothermal imaging capability. Moreover, after intravenous administration 4T1 tumor-bearing mice treatment safe-intensity (1.0 W cm-2 nm) irradiation, temperature increased rapidly to 52 °C within 1 min tumors are completely ablated single Overall, this offers novel strategy develop superb agents highly efficient cancer.

Language: Английский

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Semiconducting Polymers Containing Benzobisthiadiazole Based on Donor Conjugation Extension Strategy Enabling NIR-II Photoacoustic Imaging Performance Improvement

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

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Regulating photothermal properties of near-infrared croconaine dyes by supramolecular assembly

Nano Research, Journal Year: 2024, Volume and Issue: 17(9), P. 8560 - 8570

Published: Aug. 1, 2024

Language: Английский

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Conjugated Polymer for NIR-II Phototheranostics toward Tumor

Chemistry of Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Due to the strong light trapping ability, good biocompatibility, and easily regulated molecular structure, conjugated polymers are becoming a promising tool for phototheranostics of tumors, which can achieve both precise diagnosis efficient therapeutics. Of particular interest is polymer-based theranostic agents applying second near-infrared (NIR-II) window (1000–1700 nm), exhibit great potential clinical applications on account extremely long wavelength. Herein, basic mechanism, advances in recent 6 years, perspectives polymer NIR-II toward tumor discussed successively. First, mechanisms most widely employed modalities presented. In view heat generation property under photoexcitation, fluorescence imaging (FLI)-guided photothermal therapy (PTT) photoacoustic (PAI)-guided PTT. Then, related FLI-guided PTT technology, PAI-guided multimodel theranostics introduced. Finally, development illustrated practical application simultaneously situ tumor.

Language: Английский

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Phototherapeutic applications of benzophenone-containing NIR emitting photosenzitisers based on different receptor modulations

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(38), P. 9533 - 9544

Published: Jan. 1, 2024

Photodynamic therapy (PDT) plays a crucial role in treating cancer and major infectious diseases. However, the hypoxic microenvironment deep-seated tumors often compromise effectiveness of photosensitizers (PSs). PSs primarily generate type-II reactive oxygen species (ROS), which are limited under conditions. Pyridinium salts frequently exhibit critical dark toxicity

Language: Английский

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Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

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A NIR-II Fluorescence Probe for Tracking Oxidative Stress in Plants Induced by Metal Contaminants

Analytical Methods, Journal Year: 2024, Volume and Issue: 16(48), P. 8316 - 8323

Published: Jan. 1, 2024

An activatable NIR-II probe has been developed for tracking metal ion-induced oxidative stress in plants, which generates fluorescence signals response to NO and is good advancing plant health assessment environmental monitoring.

Language: Английский

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