Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine DOI Creative Commons
Yuwen Wang, Xin Zhang, Denghui Xie

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as promising approach to regulating fate regenerative medicine. However, few reviews provide comprehensive examination recent advancements chiral applications regulation. Herein, various fabrication techniques available for biomaterials, including use molecules, surface patterning, self‐assembly discussed. The mechanisms through which influence responses, such modulation adhesion receptors, intracellular signaling, gene expression, explored. Notably, demonstrated ability guide stem cell differentiation augment tissue‐specific functions. potential musculoskeletal disorders, neurodegenerative diseases, cardiovascular wound healing highlighted. Challenges future perspectives, standardization methods translation clinical settings, addressed. In conclusion, offer exciting prospects precisely controlling fate, advancing medicine, enabling personalized therapeutic strategies.

Language: Английский

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications DOI

Sravan Baddi,

Auphedeous Y. Dang-i,

Fengli Gao

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

Citations

4
Chiral Supramolecular Hydrogels Regulating Both Osteoblastogenesis and Osteoclastogenesis DOI Creative Commons
Beibei Wu, Xiaoqiu Dou,

Sravan Baddi

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 112 - 112

Published: Feb. 5, 2025

Osteoporosis, a chronic bone disorder, poses global threat to the health of millions individuals. The disruption homeostasis is fundamental cause osteoporosis. Currently, clinical drugs are employed promote formation via enhancing osteogenesis and/or reduce loss inhibiting osteoclastogenesis. However, it difficult for current simultaneously address osteoblastogenesis and osteoclastogenesis issues associated with Hence, L/D-phenylalanine derivatives (L/DPF), combined Mg2+ ions, assemble into chiral supramolecular hydrogels which facilitate osteocyte activity inhibit osteoclast function. LPF_Mg DPF_Mg demonstrate opposite chirality. Specifically, composed left-handed (M-type) helical nanofibers right-handed (P-type) nanofibers, respectively. hydrogen bonding π–π stacking interactions crucial in process hydrogel formation. nanofibrous significantly osteogenic differentiation MC3T3 cells RAW267.4 cells, thereby demonstrating substantial potential applications improving skeletal health. These findings provide promising novel perspective on application functional materials osteoporosis therapy.

Language: Английский

Citations

0
Metabolic Reprogramming of Neural Stem Cells by Chiral Nanofiber for Spinal Cord Injury DOI Creative Commons
Haining Wu, Chao Xing, Beibei Yu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. This report discusses biomimetic dextral hydrogel (DH) with right-handed nanofibers that specifically reprograms lipid metabolism NSCs, promoting their differentiation and rapid damaged axons. The underlying mechanism is intrinsic stereoselectivity between DH fatty acid-binding protein 5 (FABP5), which facilitates transportation acids bound FABP5 into mitochondria endoplasmic reticulum, subsequently augmenting acid oxidation (FAO) levels enriching sphingosine biosynthesis. In rat SCI model, significantly improved Basso–Beattie–Bresnahan (BBB) locomotor scores (over 3-fold) hindlimbs' compound muscle action 4-fold) compared untreated group, conveying a significant return functional recovery. finding nanoscale chirality-dependent provides insights understanding cell physiology presents opportunities regenerative medicine.

Language: Английский

Citations

0
Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine DOI Creative Commons
Yuwen Wang, Xin Zhang, Denghui Xie

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as promising approach to regulating fate regenerative medicine. However, few reviews provide comprehensive examination recent advancements chiral applications regulation. Herein, various fabrication techniques available for biomaterials, including use molecules, surface patterning, self‐assembly discussed. The mechanisms through which influence responses, such modulation adhesion receptors, intracellular signaling, gene expression, explored. Notably, demonstrated ability guide stem cell differentiation augment tissue‐specific functions. potential musculoskeletal disorders, neurodegenerative diseases, cardiovascular wound healing highlighted. Challenges future perspectives, standardization methods translation clinical settings, addressed. In conclusion, offer exciting prospects precisely controlling fate, advancing medicine, enabling personalized therapeutic strategies.

Language: Английский

Citations

2