ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
13(1), P. 507 - 517
Published: Dec. 19, 2024
Ethyl
cellulose
(EC)
is
a
biocompatible,
renewable,
and
recyclable
material
with
diverse
sources,
making
it
an
attractive
candidate
for
industrial
applications.
Electrospinning
has
gained
significant
attention
the
production
of
EC
fibers.
However,
conventional
electrospinning
methods
face
challenges
such
as
bead
formation,
low
yield,
absence
porous
internal
structures,
limiting
both
functional
performance
scalability.
This
study
presents
optimized
approach
producing
fibers
by
using
gravity-driven
ultrahigh-speed
(GUHS-ES)
system.
system
leverages
gravity
to
reshape
Taylor
cone
morphology
during
electrospinning,
enhancing
stability
dramatically
increasing
throughput.
As
flow
rates
increase,
contracts
inward,
while
tip
structure
expands
stabilizes,
reaching
maximum
size
at
ultrahigh
(100–150
mL/h).
unique
enables
fiber
rate
24.5
g/h,
hundreds
times
greater
than
techniques.
Another
advantage
GUHS-ES
its
ability
achieve
high
diameter
uniformity
adjustable
porosity.
At
rates,
pore
sizes
reached
321
nm.
The
highly
exhibited
absorption
capacity
56.6
110.7
their
weight,
exceeding
most
previously
reported
oil-absorbing
materials
demonstrating
efficacy
rapid
waste
oil
absorption.
green,
efficient
technology
represents
promising
advancement
large-scale
application
natural
polymer
broad
implications
sustainable
processes.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(7), P. 4114 - 4144
Published: June 3, 2024
Nanofiber
scaffolds
have
gained
significant
attention
in
the
field
of
bone
tissue
engineering.
Electrospinning,
a
straightforward
and
efficient
technique
for
producing
nanofibers,
has
been
extensively
researched.
When
used
engineering
scaffolds,
electrospun
nanofibers
with
suitable
surface
properties
promote
new
growth
enhance
cell
adhesion.
Recent
advancements
electrospinning
technology
provided
innovative
approaches
scaffold
fabrication
This
review
comprehensively
examines
utilization
evaluates
relevant
literature.
The
begins
by
presenting
fundamental
principles
methodologies
electrospinning.
It
then
discusses
various
materials
production
nanofiber
engineering,
including
natural
synthetic
polymers,
as
well
certain
inorganic
materials.
challenges
associated
these
are
also
described.
focuses
on
novel
techniques
construction
such
multilayer
multifluid
electrospinning,
integration
other
methods.
enabled
precisely
aligned
nanoscale
architectures.
These
methods
facilitate
biomimetic
structures,
wherein
bioactive
substances
can
be
incorporated
released
controlled
manner
drug
delivery
purposes.
Moreover,
they
address
issues
encountered
traditional
mechanical
characteristics
biocompatibility.
Consequently,
development
implementation
technologies
revolutionized
BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(4), P. 94 - 94
Published: April 4, 2024
The
human
mandible's
cancellous
bone,
which
is
characterized
by
its
unique
porosity
and
directional
sensitivity
to
external
forces,
crucial
for
sustaining
biting
stress.
Traditional
computer-
aided
design
(CAD)
models
fail
fully
represent
the
bone's
anisotropic
structure
thus
depend
on
simple
isotropic
assumptions.
For
our
research,
we
use
latest
versions
of
nTOP
4.17.3
Creo
Parametric
8.0
software
make
biomimetic
Voronoi
lattice
that
accurately
reflect
complex
geometry
mechanical
properties
trabecular
bone.
bone
modeled
in
this
work
using
models.
porosities
range
from
70%
95%,
can
be
achieved
changing
pore
sizes
1.0
mm,
1.5
2.0
2.5
mm.
Finite
element
analysis
(FEA)
was
used
examine
displacements,
stresses,
strains
acting
dental
implants
with
a
buttress
thread,
abutment,
retaining
screw,
load
surface.
results
show
model
depicts
anatomy
jaw,
compared
standard
solid
block
ideal
size
2
taking
account
both
von
Mises
stress
distribution
over
implant,
screw
retention,
cortical
micromotions.
This
displayed
balanced
performance
successfully
matching
natural
characteristics.
Advanced
FEA
improves
biomechanical
understanding
how
bones
interact
creating
more
accurate
biological
problems
dynamic
loading
situations.
makes
engineering
better.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
This
study
focuses
on
developing
hybrid
scaffolds
incorporating
phytotherapeutic
agents
via
a
combination
of
three‐dimensional
(3D)
printing
and
electrospinning
to
enhance
mechanical
properties
provide
antibacterial
activity,
in
order
address
the
limitations
traditional
antibiotics.
In
this
regard,
3D‐printed
polycaprolactone
(PCL)
struts
are
first
fabricated
using
fused
deposition
modeling
(FDM).
Then,
alkaline
surface
treatment
is
applied
improve
adhesion
electrospun
nanofibers.
Finally,
peppermint
oil
(PEP)
or
clove
(CLV)‐incorporated
PCL‐gelatin
(GEL)
nanofibers
collected
top
PCL
by
electrospinning.
Incorporating
PEP
CLV
into
PCL‐GEL
enhances
scaffold's
layer
detachment
force.
addition,
DPPH
free
radical
scavenging
activity
assay
indicates
that
improves
antioxidant
scaffolds.
Further,
results
reveal
incorporated
exhibit
inhibition
against
Staphylococcus
aureus
Escherichia
coli
bacteria.
Moreover,
anti‐inflammatory
assays
show
reduce
concentration
nitric
oxide
(NO)
released
from
Raw
264.7
macrophage‐like
cells.
On
other
hand,
hierarchical
have
no
toxic
effect
normal
human
dermal
fibroblast
(NHDF)
cells,
cell
attachment
proliferation.
Overall,
natural
shows
promise
for
advancing
wound
healing
applications.