Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review DOI Creative Commons
Tingyu Yang, Rina Sa, Furong Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 13, 2024

Piezoelectric materials, as a class of materials capable generating electrical charges under mechanical vibration, have special piezoelectric effects and been widely applied in various disease treatment fields. People generate vibrations the oral cavity during daily activities such brushing teeth, using electric toothbrushes, chewing, speaking. These natural (or external ultrasound) provide ideal conditions for activating leading to their high potential applications protecting health treating diseases. Based on this, this review reports research progress trends protection diseases past 5 years, discusses its mechanism, challenges shortcomings, aiming theoretical basis new ideas future application field cavity. Finally, brief outlook is provided, suggesting that may enable them quickly move towards real clinical applications.

Language: Английский

Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect DOI
Huijuan Zheng, Huimin Lin, Hao Tian

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

Citations

11
Piezo‐Electrons Induced Endoplasmic Reticulum Protein Misfolding to Enhance Immune Checkpoint Blockage Cancer Therapy DOI
Zhuo Li, Meng Yuan, Jinhui Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract The endoplasmic reticulum (ER) is a crucial organelle in eukaryotic cells that regulates protein synthesis, folding, and transport, playing vital role maintaining homeostasis functions. Tumor evade the immune surveillance killing of body by synthesizing checkpoint proteins ER, thereby inhibiting T cell‐mediated antitumor responses enhancing tumor tolerance, leading to poor efficacy cancer immunotherapy. Herein, an ultrasound‐triggered piezo‐nanomedicine designed with targeting function (BTO v ‐T ER ) achieve novel blockade therapy. Under ultrasound irradiation, BTO releases piezo‐electrons reducing properties disrupt redox cell reticulum, inducing misfolding apoptosis, which activates response. Meanwhile, due abnormal folding expression proteins, such as Programmed death ligand 1 (PD‐L1) downregulated, reactivating promoting strategy interfering processing various within via piezo‐catalysis provides approach for

Language: Английский

Citations

1
Near-infrared-II photocharging nanozyme for enhanced tumor immunotherapy DOI
Anshuo Li,

Shuzhen Chu,

Meng Yuan

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 676, P. 783 - 794

Published: July 22, 2024

Language: Английский

Citations

4
Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO3 Piezoelectric Nanomaterials in Tumor Treatment DOI Creative Commons

Yajuan Gong,

Qi Jin, Shuo Huang

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Language: Английский

Citations

0
Homologous Boron Nitride Heterostructure: Piezoelectricity, Catalysis, and Nitric Oxide Release to Reprogram the Tumor Microenvironment for Anticancer DOI

Xinyan Huang,

Fengyu Qu,

Yajie Ma

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

The tumor microenvironment (TME) inherently exhibits treatment resistance, which restrains the therapeutic effect. Here, intracellular piezoelectric catalysis and stepwise nitric oxide (NO) release were integrated to modulate TME for anticancer therapy. A homologous boron nitride (BN) heterostructure (BN3:1) was prepared, promotes character facilitates spatial separation of ultrasound (US)-generated charges. electrons dominate reactive oxygen species (ROS) generation, holes also consume endogenous glucose nicotinamide adenine dinucleotide phosphate (NADPH). simultaneous reactions not only facilitate charge but disrupt metabolism. In addition, BN3:1 releases NO in response TME-specific H+/H2O2. Under US irradiation, increased ROS generation boosts damage DNA/mitochondria decompose extracellular matrix (ECM). Without US, moderate is conducive vascular normalization, hypoxia relief, PD-L1 downregulation. Furthermore, microbubbles amplify imaging contrast, endowing efficient monitoring vitro vivo. It first time employing BN nanosheets as sonosensitizers donors. synergistic effect grants great efficiency, can arouse an immune further fight against metastasis recurrence.

Language: Английский

Citations

0
Ultrasound-triggered piezoelectric biomaterials for enhanced cancer sonodynamic immunotherapy DOI Creative Commons
Yuchen V. Bai,

Kehua Jiang,

Wen Deng

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 119, P. 107402 - 107402

Published: May 29, 2025

Language: Английский

Citations

0
Biopiezoelectric-based nanomaterials; a promising strategy in cancer therapy DOI Creative Commons
Tingting Zuo, Saikat Dewanjee, Chao Zhang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: June 4, 2025

Language: Английский

Citations

0
NIR-Mediated Pyroelectric Catalysis for Sustained ROS/RNS Generation and Advanced Cancer Therapy In Vivo via Injectable Hydrogel DOI
Yandai Lin, Yanxi Yang,

Xueli Ren

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 38942 - 38955

Published: July 23, 2024

Exogenous electrical stimulation has attracted considerable attention due to the advantages of microelectric induction and subsequent biological effects such as actin reorganization reactive oxygen species (ROS) generation. Herein, an injectable hydrogel BPR-ARG@Gel (BAG) with pyroelectric BPR nanoparticle loading l-arginine (ARG) introduction was fabricated for advanced cancer therapy in vivo. Due photothermal effect, holes electrons nanoparticles were separated produce open-circuit voltage consequently catalyze water H2O generate toxic superoxide (•O2–) hydroxyl radicals (•OH). These ROS substances further oxidize ARG NO synergistic tumor treatments. The mice experiments indicated that employment BAG incorporation a near-infrared laser downregulated heat shock protein recruited immune cells 5-fold-enhanced expression proinflammatory cytokines interferon-γ. It also noteworthy substantially induced generation oxygen/nitrogen (ROS/RNS) reliable biosafety strong inhibition. Overall, these findings have provided potentially new inspirations feasible strategy translate this multifunctional toward manner.

Language: Английский

Citations

3
Revealing the Optimization Route of Piezoelectric Sonosensitizers: From Mechanism to Engineering Methods DOI

Pengyu Zang,

Chenghao Yu, Rui Zhang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Piezoelectric catalysis is a novel catalytic technology that has developed rapidly in recent years and attracted extensive interest among researchers the field of tumor therapy for its acoustic-sensitizing properties. Nevertheless, are still controversial about key technical difficulties modulation piezoelectric sonosensitizers applications, which undoubtedly major obstacle to performance sonosensitizers. Clarification this challenge will be beneficial design optimization future. Here, authors start from mechanism elaborate methods defect engineering phase based on energy band theory. The combined therapeutic strategy with enzyme immunotherapy introduced. Finally, challenges prospects highlighted. Hopefully, explorations can guide toward applied their own research.

Language: Английский

Citations

2
Characteristics of Ultrasound-Driven Barium Titanate Nanoparticles and the Mechanism of Action on Solid Tumors DOI Creative Commons

Shuao Li,

Ningning He, Xiao Yu Wu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12769 - 12791

Published: Nov. 1, 2024

Sonodynamic therapy (SDT) utilizes specific sound waves to activate sonosensitizers, generating localized biological effects eliminate tumor cells. With advancements in nanomedicine, the application of nano-acoustic sensitizers has significantly advanced development SDT. BaTiO3 (BTO), an inorganic sensitizer, possesses light refraction characteristics and a high dielectric constant, can generate electric field under ultrasound (US) stimulation. continuous progress multidisciplinary fields US research, scientists have developed various types barium titanate nanoparticles (BTNPs) further advance SDT research applications therapy. In this review, we present recently proposed representative BTNPs, including their pathways action, such as induction cell senescence, ferroptosis, glutathione depletion reshape microenvironment, well surface modifications. Research indicates that mechanisms action ultrasound-driven BTNPs are multifaceted. These mechanisms, whether utilized individually or synergistically, offer potent targeted strategy for cancer treatment. Furthermore, discuss types. Finally, summarize current challenges future prospects clinical translation BTNPs.

Language: Английский

Citations

1