Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field

Language: Английский

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An intelligent core–shell microneedle patch loaded with oxygen-vacancy-engineered ROS nanogenerators for a programmed ICB therapy against “cold” tumors

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160621 - 160621

Published: Feb. 1, 2025

Language: Английский

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Fe-Doped Carbon Dots-Incorporated In Situ Hydrogel for Near Infrared-Triggered Cascading Photothermal/Thermodynamic Therapy to Boost Cancer Immunity Cycle

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Photothermal therapy-triggered whole-tumor cell antigens release has revolutionized in situ cancer vaccine, but insufficient anticancer immunity cycle activation greatly limits its curative effect. Herein, we designed an NIR-triggered cascading vaccine (FCDs-A/C@HGs) by incorporating the Fe-doped carbon dots (FCDs), azo-initiator (AIPH), and immune adjuvant (cyclophosphamide) into thermosensitive hydrogel. Due to iron doping, as-prepared FCDs exhibited high photothermal conversion performance favorable MR imaging capability. Upon intratumoral injection, local hyperthermia mediated FCDs-A/C@HGs subsequent generation of alkyl radicals from AIPH synergistically induced immunogenic death tumor cells. Remarkably, elicited strong inhibiting regulatory T cells promoting dendritic maturation, thereby enhancing differentiation cytotoxic CD8+ memory This study presents effective therapeutic platform for suppression sustained cycle.

Language: Английский

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Heteroatom Doping Promoted Ultrabright and Ultrastable Photoluminescence of Water-Soluble Au/Ag Nanoclusters for Visual and Efficient Drug Delivery to Cancer Cells

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34510 - 34523

Published: July 1, 2024

Photoluminescence (PL) metal nanoclusters (NCs) have attracted extensive attention due to their excellent physicochemical properties, good biocompatibility, and broad application prospects. However, developing water-soluble PL NCs with a high quantum yield (QY) stability for visual drug delivery remains great challenge. Herein, we synthesized ultrabright l-Arg-ATT-Au/Ag (Au/Ag NCs) QY as 73% photostability by heteroatom doping surface rigidization in aqueous solution. The as-prepared Au/Ag can maintain of over 61% wide pH range various ionic environments well respectable resistance photobleaching. results from structure characterization steady-state time-resolved spectroscopic analysis reveal that Ag into Au not only effectively modifies the electronic but also significantly regulates interfacial dynamics excited states enhances NCs. Studies vitro indicate loading capacity pH-triggered release ability doxorubicin (DOX) be visualized quenching recovery intensity lifetime. Imaging-guided experiments cancer cells show DOX NCs–DOX agents efficiently delivered released nucleus preferential accumulation nucleolus, facilitating deep insight action sites pharmacological mechanisms. Moreover, evaluation anticancer activity vivo reveals an outstanding suppression rate 90.2% mice tumors. These findings demonstrate superior platform bioimaging biomedical applications.

Language: Английский

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Effect of hyaluronic acid on the formation of acellular dermal matrix-based interpenetrating network sponge scaffolds for accelerating diabetic wound healing through photothermal warm bath

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137268 - 137268

Published: Nov. 4, 2024

Language: Английский

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Photothermal-Triggered Extracellular Matrix Clearance and Dendritic Cell Maturation for Enhanced Osteosarcoma Immunotherapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Osteosarcoma, a predominant malignant tumor among adolescents, exhibits high mortality and suboptimal immunotherapy efficacy due to collagen-dense extracellular matrix (ECM) that hinders cytotoxic T lymphocyte (CTL) infiltration. Herein, we developed mesoporous polydopamine (MPDA) nanoparticles encapsulating bromelain the immune adjuvant R848 (M@B/R), aimed at enhancing photothermal immunotherapy. These efficiently accumulate site following injection. Upon near-infrared (NIR) light irradiation, therapy (PTT) induces immunogenic cell death in cells and, with aid of R848, promotes dendritic maturation, activating antitumor immunity leading CTL infiltration into tumor. Concurrently, NIR-induced heating activates bromelain, resulting ECM degradation improved penetration Our vivo evaluations demonstrate potent effects osteosarcoma-bearing mice. This integrated approach offers promising strategy for overcoming physical barriers ECM-rich tumors, marking significant advancement treatment osteosarcoma.

Language: Английский

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Natural lignin nanoparticles target tumor by saturating the phagocytic capacity of Kupffer cells in the liver

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133186 - 133186

Published: June 15, 2024

Language: Английский

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Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 1060 - 1074

Published: Aug. 31, 2024

Language: Английский

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Fe ₃ O ₄ nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

Cell Adhesion & Migration, Journal Year: 2024, Volume and Issue: 18(1), P. 38 - 53

Published: Nov. 13, 2024

This research aims to study the effect of magnetic nanoparticles Fe3O4 (MNP Fe3O4) containing gambogic acid (GA-MNP on colorectal cancer (CRC). MNP enhanced antitumor GA by inhibiting malignant behavior CRC cells. RORB was a target GA, and activated expression inhibit metastasis CRC. Knockdown impaired GA-MNP metastasis. EMILIN1 RORB, promoted transcription EMILIN1. Overexpression reversed knockdown inhibited in These findings revealed that promote

Language: Английский

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Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 232, P. 116695 - 116695

Published: Dec. 4, 2024

Language: Английский

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