“One‐Pot” Synthesized Phosphorus Corrole‐Based Metal–Organic Frameworks for Synergistic Phototherapy and Chemodynamic Therapy DOI Open Access
Wenbo Deng, Zixiang Wei,

Yunhao Xu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract As a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal–organic frameworks (MOFs) that incorporate photosensitive as functional ligands for synergistic remains formidable challenge. Herein, the first time, phosphorus corrole‐based MOFs Cor(P)‐Hf with (3,18)‐connected gea topology are reported, which constructed by Cs ‐symmetric dicarboxylate 3‐connected linkers, 10‐pentafluorophenyl‐5,15‐di( p ‐benzoate)phosphorus corrole (Cor(P)), and peculiar D 3h 18‐connected Hf 12 ‐oxo clusters. Interestingly, six para ‐position F substituents Cor(P) linkers found be coordinated apex cluster through Hf‐F bonds along c‐axis direction, is believed help stabilize framework. Furthermore, mixed corrolic ligand‐based Cor(P)/Cor(Cu)‐Hf Cor(P)/Cor(Fe)‐Hf involving Cor(Fe) or Cor(Cu) secondary simple “one‐pot” solvent‐thermal method, respectively. Remarkably, facilitates combining photodynamic therapy (PDT), photothermal (PTT), chemodynamic (CDT) when activated an 808 nm laser, evidenced vivo vitro experiments. This study demonstrates powerful multifunctional nanoplatform anti‐cancer phototherapy.

Language: Английский

Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip DOI

Yueqing Chen,

Genhui Lin,

Ziyi Wang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 264, P. 116668 - 116668

Published: Aug. 12, 2024

Language: Английский

Citations

5
NIR II Laser-Triggered Photothermal Nanoplatform for Multimodal Imaging-Guided Synergistic Therapy toward Colon Cancer DOI
Guodong Ren, Xuewei Wang, Jianbo Cao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Colon cancer is one kind of malignant digestive tract tumor with high morbidity and mortality worldwide, treatments for which still face great challenges. Recently emerged intervention strategies such as phototherapy gas therapy have displayed promising effects in the treatment colon cancer, but their application are hindered due to insufficient targeting deeper tissue penetrating capacity. Herein, present study, we developed theranostic nanoplatform Cet-CDs-SNO (CCS) realize multimodal imaging-guided synergistic therapy. Among CCS, Cetuximab (Cet), first-line clinical drugs colorectal endowed CCS tumor-targeting capacity enhanced drug accumulation cells; CDs doped by Ni2+ Mn2+ served NIR-II photothermal (PTT), chemodynamic (CDT), photothermal/magnetic resonance/fluorescence imaging (PTI/MRI/FLI) agents; SNO, a nitric oxide (NO) donor, exerted therapeutic (GT) under thermal stimulation derived from PTT. In vitro vivo experiments proved that had excellent cancer-targeting ability. Proliferation cells growth were significantly inhibited administration without detectable cytotoxicity. This study presented strategy developing multifunctional be applied precise

Language: Английский

Citations

0
NIR-responsive CaCO3@ BMP-2/PDA Nanocomposite for Multifunctional Therapy in Periodontitis DOI
Xue Chen, Jingxiu Bi, Haoyang Zhang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136520 - 136520

Published: Feb. 1, 2025

Language: Английский

Citations

0
Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors DOI
Ruipeng Li, Haitao Yuan,

Chuangxin Zhang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Overcoming the resistance of tumor cells to apoptosis and immunosuppression is an important challenge improve immunotherapy. Non‐apoptotic death mode ferroptosis has been regarded as a new strategy enhance immunotherapy against drug‐resistant cancers. The lethal accumulation lipid peroxides (LPO) determines progress ferroptosis. high susceptibleness provides opportunity for combating triple‐negative breast cancer. Reactive nitrogen species (RNS) produced by nitric oxide (NO) reactive oxygen (ROS) more than ROS cells. Herein, RNS‐mediated inducing pathway proposed improving LPO accumulation, constructed multifunctional liposome (Lipo‐MT‐SNAP) comprised peroxynitrite (ONOO − ) generator, targeted group, inhibiting glutathione peroxidase 4 (GPX4), basic units (dipalmitoyl phosphatidylcholine cholesterol). significant enhancement resulted from intense oxidative damage ONOO impaired synthesis GPX4 depleting glutathione, which further amplified triggered immunogenic cell death. In vivo, photoimmunotherapy can promote polarization M2 M1 macrophages dendritic maturation, infiltrate T cells, regulate secretion inflammatory factors, reprogram microenvironment. powerful induces strong immunogenicity effectively inhibit proliferation.

Language: Английский

Citations

2
DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy DOI

Cui Ren,

Zhiyong Shi, Xiaowen Zhang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 434 - 445

Published: Dec. 3, 2024

Language: Английский

Citations

1
Photoferroptosis as a potent strategy for neuroblastoma treatment DOI
Wenxin Zhang,

Xiaodie Li,

C. Q. Feng

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 59, P. 102498 - 102498

Published: Sept. 12, 2024

Language: Английский

Citations

0
“One‐Pot” Synthesized Phosphorus Corrole‐Based Metal–Organic Frameworks for Synergistic Phototherapy and Chemodynamic Therapy DOI Open Access
Wenbo Deng, Zixiang Wei,

Yunhao Xu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract As a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal–organic frameworks (MOFs) that incorporate photosensitive as functional ligands for synergistic remains formidable challenge. Herein, the first time, phosphorus corrole‐based MOFs Cor(P)‐Hf with (3,18)‐connected gea topology are reported, which constructed by Cs ‐symmetric dicarboxylate 3‐connected linkers, 10‐pentafluorophenyl‐5,15‐di( p ‐benzoate)phosphorus corrole (Cor(P)), and peculiar D 3h 18‐connected Hf 12 ‐oxo clusters. Interestingly, six para ‐position F substituents Cor(P) linkers found be coordinated apex cluster through Hf‐F bonds along c‐axis direction, is believed help stabilize framework. Furthermore, mixed corrolic ligand‐based Cor(P)/Cor(Cu)‐Hf Cor(P)/Cor(Fe)‐Hf involving Cor(Fe) or Cor(Cu) secondary simple “one‐pot” solvent‐thermal method, respectively. Remarkably, facilitates combining photodynamic therapy (PDT), photothermal (PTT), chemodynamic (CDT) when activated an 808 nm laser, evidenced vivo vitro experiments. This study demonstrates powerful multifunctional nanoplatform anti‐cancer phototherapy.

Language: Английский

Citations

0