Copper homeostasis and Cuprotosis: Exploring novel therapeutic strategies for connective tissue diseases DOI
Wenlan Zhang, Zhijie Song, Yuanyuan Tian

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113698 - 113698

Published: Dec. 6, 2024

Language: Английский

Bimodal analysis of intracellular in situ self-assembled Au complexes based on single-cell electrochemistry DOI
Ke Huang, Hui Jiang,

Yi Han Wang

et al.

Journal of Electroanalytical Chemistry, Journal Year: 2024, Volume and Issue: 960, P. 118193 - 118193

Published: March 19, 2024

Language: Английский

Citations

1
Dual Approach: Micellar Delivery of Chlorambucil Prodrug with Concurrent Glutathione Depletion and GST Inhibition for Enhanced Anticancer Activity DOI Creative Commons

Shaojie Wu,

Kuofei Liao,

Jiamin Chen

et al.

Nanotechnology, Journal Year: 2024, Volume and Issue: 35(34), P. 345601 - 345601

Published: May 24, 2024

Although chlorambucil (CHL) is a long-established anticancer drug, the drug failure of CHL, mediated by intracellular defense system consisting glutathione (GSH) and GSH S-transferase pi (GST-pi), has significantly limited application CHL. To overcome this issue, we first designed GSH-responsive small-molecule prodrug (EA-SS-CHL) combining CHL ethacrynic acid (EA). Subsequently, drug-loaded nanoparticles (ECPP) were formed self-assembly between EA-SS-CHL amphiphilic PEG-PDLLA to improve water solubility its ability target tumor sites. Upon exposure high concentration, gradually degrades, leading release EA The presence facilitates depletion inhibition GST-pi, ultimately attenuating detoxification Cytotoxicity studies apoptosis assays demonstrate that ECPP exhibits higher therapeutic efficiency than Additionally,

Language: Английский

Citations

0
A multifunctional nanoplatform combining self-supplied H2O2 production with CO delivery for multimodal anti-tumor therapy DOI
Mengjie Chen, Chengbin Wang, Hailin Zhang

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(36), P. 15956 - 15964

Published: Jan. 1, 2024

Covalent grafting of a MnCO complex on Cu 2+ –polydopamine-modified CaO 2 carrier yielded nanoplatform with enhanced intracellular ROS production and cellular calcification under 808 nm irradiation, achieving efficient multimodal therapy for cancer.

Language: Английский

Citations

0
An effective and specific cancer theranostic nanoplatform with NIR-II fluorescence imaging-guided photothermal/chemodynamic therapy DOI

Tingxi Han,

Di Cui,

Meng Wu

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111466 - 111466

Published: Aug. 25, 2024

Language: Английский

Citations

0
Self-assembly of Cu-glutathione nanoparticles on WO3 nanorods: amelioration of charge transfer and photocatalytic performance DOI

Er-da Zhan,

Zhiyu Liang, Ying Wang

et al.

CrystEngComm, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Under visible light irradiation, the Cu GSH/WO 3 photocatalyst demonstrated excellent degradation performance for organic pollutants, achieving of 99.8% Rh B and 98.6% TC within 60 minutes.

Language: Английский

Citations

0
Multienzyme-like polyoxometalate for oxygen-independent sonocatalytic enhanced cancer therapy DOI
Han Yang, Xueyu Li, Qian Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 319 - 330

Published: Nov. 23, 2024

Language: Английский

Citations

0
Copper homeostasis and Cuprotosis: Exploring novel therapeutic strategies for connective tissue diseases DOI
Wenlan Zhang, Zhijie Song, Yuanyuan Tian

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113698 - 113698

Published: Dec. 6, 2024

Language: Английский

Citations

0