Complexes containing zinc: synthesis, characterization, molecular docking, anticipated pkCSM value, and anticipated biological implications DOI

Mohd Washid Khan,

Amit K. Shukla,

Sahil S. Thakur

et al.

International Journal of Newgen Research in Pharmacy & Healthcare, Journal Year: 2024, Volume and Issue: unknown, P. 176 - 186

Published: June 30, 2024

The application of transition metal complexes as biochemical, medicinal, analytical, pharmacological, agronomic, antibacterial, and anticancer agents is gaining attention.There are numerous medicinal uses for sulfonamides metal-sulfonamide complexes. pharmacokinetic profile describes the process by which a compound absorbed, distributed, metabolized, eliminated from body. effectiveness drug influenced its potency, toxicity, pharmacokinetics. Molecular docking allows development medications based on their structures predicting preferred binding orientation molecules in stable In order to optimize drug-like qualities, must strike balance between pharmacokinetics, effectiveness, safety. enhanced activities zinc ligand generally explained agar diffusion method. Researchers used method conduct vitro antibacterial activity studies results these revealed that exhibited higher levels than precursor ligand. particular, Zn(II) complex had percent index (62, 90%) both Cu(II) (54, 82%) Ni(II) (41, 68%) when tested against A. niger C. albicans, respectively. novel medicine be presented clinic, it essential reaches therapeutic target adequate quantities safely provide desired physiological impact. While pharmaceutical's perfect qualities significant, they alone not sufficient.

Language: Английский

Enhancing X‐Ray Sensitization with Multifunctional Nanoparticles DOI Creative Commons
Jiayi Liu, Junyong Wu, Taili Chen

et al.

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: April 26, 2024

Abstract In the progression of X‐ray‐based radiotherapy for treatment cancer, incorporation nanoparticles (NPs) has a transformative impact. This study investigates potential NPs, particularly those comprised high atomic number elements, as radiosensitizers. aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications NPs in encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along contributions photodynamic/photothermal therapy, imaging enhancement, integration artificial intelligence technology. Despite promising preclinical outcomes, paper acknowledges challenges clinical translation these findings. conclusion maintains an optimistic stance, emphasizing ongoing trials technological advancements that bolster personalized approaches. advocates continuous research validation, envisioning revolutionary paradigm cancer ultimately enhancing patient outcomes.

Language: Английский

Citations

7
Rapid synthesis of manganese dioxide nanoparticles for enhanced biocompatibility and theranostic applications DOI Creative Commons
Xueting Wang, Xiaoqing Yang, Xiaoqing Yi

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3060 - 3065

Published: Jan. 1, 2025

Rapid preparation of MnO 2 and by using for colorimetric detection GSH.

Language: Английский

Citations

0
Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC) DOI Creative Commons

Linjia Peng,

Zixuan Gao,

Yan‐Feng Liang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.

Language: Английский

Citations

0
Condensation polymerization of 2-[(para-tolyl) oxy]-4,6-dichlorotriazine with ethylenediamine and application in metal anchoring DOI

Farag M. A. Altalbawy,

Fedhil F. Seed,

Vicky Jain

et al.

Journal of Polymer Research, Journal Year: 2025, Volume and Issue: 32(3)

Published: March 1, 2025

Language: Английский

Citations

0
Boron/hydrocarbon plasma polymer nanofuels for green energy generation via laser-driven proton-boron fusion DOI Creative Commons
Marco Tosca, Mariia Protsak, Daniil Nikitin

et al.

Materials Today Sustainability, Journal Year: 2025, Volume and Issue: unknown, P. 101118 - 101118

Published: April 1, 2025

Citations

0
Reagent-free biomolecule functionalization of atmospheric pressure plasma-activated polymers for biomedical applications: Pathways for covalent attachment DOI Creative Commons
Oliver Lotz, Anyu Zhang, Masoud Zhianmanesh

et al.

Applied Surface Science, Journal Year: 2024, Volume and Issue: 662, P. 160101 - 160101

Published: April 14, 2024

Atmospheric pressure plasma jets (APPJs) are advancing as a versatile dry technology for creating biofunctional structures. Recently, reagent-free, single-step covalent immobilization of bioactive molecules onto surfaces was demonstrated. Despite this, the mechanisms governing attachment process remain obscure. Here, we studied morphological changes, concentrations radicals, and formation reactive species on APPJ-treated polymers to shed light underlying attachment. The polyethylene surfaces, prepared either in air or with controlled ambient gas composition, were analyzed using Fourier transform infrared, X-ray photoelectron, electron spin resonance, fluorescence spectroscopies, well atomic force microscopy. It demonstrated that only non-radical oxygen (ROS) could explain This also silicone (PDMS), broadening range possible applications. Finally, identify reaction pathways, fluorinated carbon brushes used, each presenting specific functional group. Attachment data indicated amine thiol groups can be covalently bound treated surfaces. As result, reactions involving ROS, hydroxyl, carbonyl, carboxyl, peroxides potential pathways. These findings provide means optimizing treatment features such binding site density future studies applications, thereby expanding capabilities APPJ within 3D bioprinters.

Language: Английский

Citations

2
Advances in nano‐preparations for improving tetrandrine solubility and bioavailability DOI
Jie Ling,

Jingping Wu,

Yuening Cao

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(10)

Published: June 20, 2024

Abstract Tetrandrine (TET) is a natural bis‐benzylisoquinoline alkaloid isolated from Stephania species with wide range of biological and pharmacologic activities; it mainly serves as an anti‐inflammatory agent or antitumor adjuvant in clinical applications. However, limitations such prominent hydrophobicity, severe off‐target toxicity, low absorption result suboptimal therapeutic outcomes preventing its widespread adoption. Nanoparticles have proven to be efficient devices for targeted drug delivery since drug‐carrying nanoparticles can passively transported the tumor site by enhanced permeability retention (EPR) effects, thus securing niche cancer therapies. Great progress has been made nanocarrier construction TET due their outstanding advantages increased water‐solubility, improved biodistribution blood circulation, reduced irritation, combinational therapy. Herein, we systematically reviewed latest advancements TET‐loaded respective features expectation providing perspective guidelines future research potential applications TET.

Language: Английский

Citations

1
Bioengineering nanomaterials for tumor therapy and anti-metastasis DOI
Junjie Cheng,

Yuanbo Pan,

Jianhua Zou

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101375 - 101375

Published: Sept. 1, 2024

Language: Английский

Citations

1
Breaking biological barriers: Engineering polymeric nanoparticles for cancer therapy DOI Creative Commons
Elmer Austria, M.M.M. Bilek, Pegah Varamini

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 60, P. 102552 - 102552

Published: Nov. 22, 2024

Language: Английский

Citations

1
Advances in nanotechnology-based approaches for the treatment of head and neck squamous cell carcinoma DOI Creative Commons

Bicai Tang,

Rui Huang,

MA Wen-juan

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(52), P. 38668 - 38688

Published: Jan. 1, 2024

Head and neck squamous cell carcinoma (HNSCC), one of the most common types cancers occurring in head region, is often associated with high mortality rates due to its invasiveness morbidity. The mainstream treatment methods clinical settings, including surgery, chemotherapy, radiotherapy, may cause poor overall survival rate prognosis, issues such as drug resistance, damage adjacent healthy tissues, potential recurrences. Other approaches immunotherapy, photodynamic therapy (PDT), photothermal (PPT) also suffer from inefficient tumor targeting suboptimal therapeutic outcomes. Early detection vital for HNSCC patients, but it always limited by insensitivity confusing manifestations. Hence, highly desirable develop optimized diagnostic strategies. With boom nanomaterials, nanotechnology-conducted has attracted widespread attention. Nanoparticles (NPs) are distinguished their unique morphology superior physicochemical property, some can exhibit direct antitumor activity, while others serve promising candidates delivery. In addition, NPs offer structural modification delivery targeting, enabling specific cells through conjugation biomarker ligands improving cargo biocompatibility. This work reviews current therapies diagnosis HNSCC, highlights characteristics major NPs, surveys uses advantages discusses obstacles prospects applications, aiming enlighten future research directions nanotechnology-based HNSCC.

Language: Английский

Citations

1