Biomaterial-based strategies: a new era in spinal cord injury treatment

Neural Regeneration Research, Journal Year: 2025, Volume and Issue: 20(12), P. 3476 - 3500

Published: Jan. 13, 2025

Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention recently. Spinal is associated with a complex molecular cellular microenvironment. This complexity has prompted researchers to elucidate underlying pathophysiological mechanisms changes identify effective treatment strategies. Traditional approaches for repair include surgery, oral or intravenous medications, administration neurotrophic factors; however, efficacy these remains inconclusive, serious adverse reactions continue be concern. With advancements in tissue engineering regenerative medicine, emerging strategies now involve nanoparticle-based nanodelivery systems, scaffolds, functional techniques that incorporate biomaterials, bioengineering, stem cell, growth factors as well three-dimensional bioprinting. Ideal biomaterial scaffolds should not only provide structural support neuron migration, adhesion, proliferation, differentiation but also mimic mechanical properties natural tissue. Additionally, facilitate axon neurogenesis by offering adjustable topography range physical biochemical cues. The three-dimensionally interconnected porous structure appropriate physicochemical enabled biomimetic printing technology can maximize potential biomaterials used treating injury. Therefore, correct selection application coupled successful clinical translation, represent promising objectives enhance review elucidates key occurrence regeneration post-injury, including neuroinflammation, oxidative stress, regeneration, angiogenesis. briefly discusses critical role systems injured cord, highlighting influence nanoparticles affect delivery efficiency. Finally, this highlights It various types their integrations cells factors, optimization scaffold design.

Language: Английский

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Enzymatically Degradable Electrospun Nanogel Scaffolds Promoted in Vitro Proliferation of rADSC

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Scaffolds that mimic the extracellular matrix (ECM) can promote proliferation of stem cells. Poly(N-isopropylacrylamide) (PNIPAM)/gelatin (PG) nanogel electrospun membranes were designed to replicate hierarchical and dynamic nature ECMs. First, PG nanogels with semi-interpenetrating network structures synthesized by emulsion polymerization. Characterization using 1H NMR FTIR spectroscopies confirmed successful incorporation gelatin into PNIPAM-based network. The spherical a size 184.1–231.9 nm, they demonstrated thermoresponsive behavior. rehydrated nanofibers exhibited an average diameter 663.6 ± 50.1 nm Young's modulus 1.3 0.1 MPa at 37 °C. membrane completely degraded within 10 min collagenase treatment. Adipose-derived cells from rats good on membranes, cell in PNI50 group being 1.47 times tissue culture plate (TCP) group. showed potential for expansion.

Language: Английский

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Stimuli-Responsive Nanomedicines for the Treatment of Non-cancer Related Inflammatory Diseases

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Nanomedicines offer a means to overcome the limitations associated with traditional drug dosage formulations by affording protection, enhanced bioavailability, and targeted delivery affected sites. Inflamed tissues possess unique microenvironmental characteristics (including excessive reactive oxygen species, low pH levels, hypoxia) that stimuli-responsive nanoparticles can employ as triggers support on-demand delivery, accumulation, controlled release, activation of anti-inflammatory drugs. Stimuli-responsive nanomedicines respond physicochemical pathological factors diseased improve specificity multidrug resistance, ensure accurate diagnosis precision therapy, control release efficacy safety. Current react intracellular/microenvironmental stimuli such pH, redox, hypoxia, or specific enzymes exogenous temperature, magnetic fields, light, ultrasound via bioresponsive moieties. This review summarizes general strategies employed produce tailored for inflammatory diseases all recent advances, reports their applications in illustrates progress made toward clinical translation.

Language: Английский

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Bioinspired fibrous scaffolds with hierarchical orientations for enhanced spinal cord injury repair

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157969 - 157969

Published: Nov. 1, 2024

Language: Английский

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