Interfacial Interactions between Neural Tracing Lectin–Gold Nanoparticle Conjugate and Cell Membrane Glycoproteins DOI Creative Commons
Joel Yong,

Dan Wang,

L. Stephen Kwok

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

The use of neural tracers as targeting molecules for drug delivery has been previously established a novel and efficient method delivery. wheat germ agglutinin-horseradish peroxidase conjugate (WGAHRP) is common tracer, which used extensively to decipher pathways in vertebrates. It widely reported bind cell surfaces be transported retrograde fashion (from synapses toward the body) via dynein motors along microtubules within axons transynaptically between neurons. Here we report on differential binding WGAHRP gold-conjugated (AuNP-WGAHRP) glycoprotein profiles extracted from two neuronal lines one skeletal muscle line, well kinetics heparin. From proteomic analysis glycoproteins, suggest identity surface glycoproteins involved transport WGAHRP. This study illuminates interfacial molecular interactions protein-gold conjugates with native ligands opens door identification new targets tracing nervous system-related

Language: Английский

Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation DOI
M. B. Sharapova,

Daniil S. Zuev,

Elizaveta Silvanovich

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Interfacial Interactions between Neural Tracing Lectin–Gold Nanoparticle Conjugate and Cell Membrane Glycoproteins DOI Creative Commons
Joel Yong,

Dan Wang,

L. Stephen Kwok

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

The use of neural tracers as targeting molecules for drug delivery has been previously established a novel and efficient method delivery. wheat germ agglutinin-horseradish peroxidase conjugate (WGAHRP) is common tracer, which used extensively to decipher pathways in vertebrates. It widely reported bind cell surfaces be transported retrograde fashion (from synapses toward the body) via dynein motors along microtubules within axons transynaptically between neurons. Here we report on differential binding WGAHRP gold-conjugated (AuNP-WGAHRP) glycoprotein profiles extracted from two neuronal lines one skeletal muscle line, well kinetics heparin. From proteomic analysis glycoproteins, suggest identity surface glycoproteins involved transport WGAHRP. This study illuminates interfacial molecular interactions protein-gold conjugates with native ligands opens door identification new targets tracing nervous system-related

Language: Английский

Citations

0