Effective and new technologies in kidney tissue engineering DOI Creative Commons
Hossein Rayat Pisheh, Mobin Haghdel, Muhammad Jahangir

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 16, 2024

Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable filter blood and remove waste products, these abnormalities can lead failure. In severe cases failure, transplantation is considered only definitive treatment. Worldwide, World Health Organization (WHO) repeatedly emphasizes importance organ donation increasing rates. Many countries implement national programs promote culture improve patient access transplantation. The extent which this procedure performed varies across influenced by several factors, including volume donation, medical infrastructure, technology health policies. However, transplant comes with challenges problems that impact its success. tissue engineering new approach shows promise for repairing replacing damaged tissue. This article reviews recent advances in engineering, focusing on engineered structures such as hydrogels, electrospinning, 3D bioprinting, microfluidic systems. By mimicking extracellular environment kidney, provide suitable conditions growth development cells. role formation vessels, mimicry functions field were also discussed. results study show has high potential treating diseases reducing need achieve clinical application technology, further research required biocompatibility, vascularization long-term performance tissues.

Language: Английский

3D printing and artificial intelligence tools for droplet microfluidics: Advances in the generation and analysis of emulsions DOI

Sibilla Orsini,

Marco Lauricella, Andrea Montessori

et al.

Applied Physics Reviews, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 21, 2025

Droplet microfluidics has emerged as highly relevant technology in diverse fields such nanomaterials synthesis, photonics, drug delivery, regenerative medicine, food science, cosmetics, and agriculture. While significant progress been made understanding the fundamental mechanisms underlying droplet generation microchannels fabricating devices to produce droplets with varied functionality high throughput, challenges persist along two important directions. On one side, generalization of numerical results obtained by computational fluid dynamics would be deepen comprehension complex physical phenomena microfluidics, well capability predicting device behavior. Conversely, truly three-dimensional architectures enhance microfluidic platforms terms tailoring enhancing flow properties. Recent advancements artificial intelligence (AI) additive manufacturing (AM) promise unequaled opportunities for simulating behavior, precisely tracking individual droplets, exploring innovative designs. This review provides a comprehensive overview recent applying AI AM microfluidics. The basic properties multiphase flows production are discussed, current fabrication methods related introduced, together their applications. Delving into use technologies topics covered include AI-assisted simulations real-time within systems, AM-fabrication systems. synergistic combination is expected active matter expediting transition toward fully digital

Language: Английский

Citations

3
Advancements in liposomal formulations: A comprehensive exploration of industrial production techniques DOI
Mohammad Sameer Khan, Garima Gupta,

Abdulrhman Alsayari

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124212 - 124212

Published: May 8, 2024

Language: Английский

Citations

10
Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review DOI Creative Commons

Mariana Ferreira,

Violeta Carvalho, João Ribeiro

et al.

Micromachines, Journal Year: 2024, Volume and Issue: 15(7), P. 873 - 873

Published: June 30, 2024

The evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools disease diagnosis, treatment, and monitoring. Numerical simulation has emerged a tool of increasing importance for better understanding predicting fluid-flow behavior microscale devices. This review explores fabrication techniques common materials devices, focusing on soft lithography additive manufacturing. Microfluidic applications, including nucleic acid amplification protein synthesis, well point-of-care diagnostics, DNA analysis, cell cultures, organ-on-a-chip models (e.g., lung-, brain-, liver-, tumor-on-a-chip), are discussed. Recent studies have applied computational such ANSYS Fluent 2024 software to numerically simulate flow behavior. Outside study cases, this work reports fundamental aspects simulations, fluid flow, mass transport, mixing, diffusion, highlights emergent simulations. Additionally, it takes into account application geometries improve mixing samples, surface wettability modification. In conclusion, present summarizes most relevant contributions their numerical modeling engineering.

Language: Английский

Citations

7
Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications DOI Creative Commons
Yingtong Luo, Yudong Li, Loai K. E. A. Abdelmohsen

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Polymeric nanoarchitectures are crafted from amphiphilic block copolymers through a meticulous self‐assembly process. The composition of these is finely adjustable, bestowing precise control over the characteristics and properties resultant polymeric assemblies. These nanoparticles have garnered significant attention, particularly in realm biological sciences, owing to their biocompatibility, favorable pharmacokinetics, facile chemically modifiable nature. Among myriad nanoarchitectures, micelles polymersomes stand out as frontrunners, exhibiting much potential cargo carrier systems for diverse bio‐applications. This review elucidates design strategies employed assemblies, specifically focusing on polymersomes. Subsequently, it discusses wide‐ranging bio‐applications, spanning drug delivery diagnostics bioimaging artificial cell applications. Finally, reflective analysis will be provided, highlighting current landscape carriers, discussing opportunities challenges that lie ahead. With this review, aimed summarize recent advances assemblies applications biomedical field.

Language: Английский

Citations

0
From specialization to broad adoption: Key trends in droplet microfluidic innovations enhancing accessibility to non-experts DOI Creative Commons
Jolien Breukers, Karen Ven, Wannes Verbist

et al.

Biomicrofluidics, Journal Year: 2025, Volume and Issue: 19(2)

Published: March 1, 2025

Droplet microfluidics has emerged as a versatile and powerful tool for various analytical applications, including single-cell studies, synthetic biology, directed evolution, diagnostics. Initially, access to droplet was predominantly limited specialized technology labs. However, the landscape is shifting with increasing availability of commercialized manipulation technologies, thereby expanding its use non-specialized Although these commercial solutions offer robust platforms, their adaptability often constrained compared in-house developed devices. Consequently, both within industry academia, significant efforts are being made further enhance robustness automation droplet-based not only facilitate transfer non-expert laboratories but also reduce experimental failures. This Perspective article provides an overview recent advancements aimed at accessibility systems enabling complex manipulations. The discussion encompasses diverse aspects such generation, reagent addition, splitting, washing, incubation, sorting, dispensing. Moreover, alternative techniques like double emulsions hydrogel capsules, minimizing or eliminating need microfluidic operations by end user, explored. These developments foreseen integration intricate manipulations users in workflows, fostering broader faster adoption across scientific domains.

Language: Английский

Citations

0
Effective and new technologies in kidney tissue engineering DOI Creative Commons
Hossein Rayat Pisheh, Mobin Haghdel, Muhammad Jahangir

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 16, 2024

Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable filter blood and remove waste products, these abnormalities can lead failure. In severe cases failure, transplantation is considered only definitive treatment. Worldwide, World Health Organization (WHO) repeatedly emphasizes importance organ donation increasing rates. Many countries implement national programs promote culture improve patient access transplantation. The extent which this procedure performed varies across influenced by several factors, including volume donation, medical infrastructure, technology health policies. However, transplant comes with challenges problems that impact its success. tissue engineering new approach shows promise for repairing replacing damaged tissue. This article reviews recent advances in engineering, focusing on engineered structures such as hydrogels, electrospinning, 3D bioprinting, microfluidic systems. By mimicking extracellular environment kidney, provide suitable conditions growth development cells. role formation vessels, mimicry functions field were also discussed. results study show has high potential treating diseases reducing need achieve clinical application technology, further research required biocompatibility, vascularization long-term performance tissues.

Language: Английский

Citations

1