Inflammation-triggered Gli1+ stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology
Xinyue Cai,
No information about this author
Chen‐Xi Zheng,
No information about this author
Hao Guo
No information about this author
et al.
Cellular and Molecular Immunology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Language: Английский
Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 8, 2025
Healthy
aging
is
a
common
goal
for
humanity
and
society,
one
key
to
achieving
it
the
rejuvenation
of
senescent
resident
stem
cells
empowerment
organ
regeneration.
However,
mechanistic
understandings
cell
senescence
potential
strategies
counteract
remain
elusive.
Here,
we
reveal
that
bone
microenvironment
impairs
Golgi
apparatus
thus
diminishing
mesenchymal
(MSC)
function
Interestingly,
replenishment
aggregates-derived
extracellular
vesicles
(CA-EVs)
rescues
dysfunction
empowers
MSCs
through
regulatory
protein
Syntaxin
5.
Importantly,
in
vivo
administration
CA-EVs
significantly
enhanced
defect
repair
rate
improved
mass
mice,
suggesting
their
therapeutic
value
treating
age-related
osteoporosis
promoting
Collectively,
our
findings
provide
insights
into
regulation
aging,
which
further
highlight
as
rejuvenative
approach
Language: Английский
Gli1+ Inflamm-Stem Cells Engage Extracellular Vesicles to Prime Aberrant Neutrophils for Exacerbating Periodontal Immunopathology
Yan Jin,
No information about this author
Xinyue Cai,
No information about this author
Chen‐Xi Zheng
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
Periodontitis
is
a
prevalent
and
progressive
detrimental
disease
which
characterized
by
chronic
inflammation,
the
immunopathological
mechanisms
being
not
yet
fully
understood.
Mesenchymal
stem
cells
(MSCs)
play
crucial
roles
as
immunoregulators
maintain
tissue
homeostasis
regeneration,
but
their
in
vivo
function
in
immunopathology
periodontal
deterioration
still
unclear.
Here,
we
utilized
multiple
transgenic
mouse
models
to
specifically
mark,
ablate
modulate
Gli1
+
cells,
critical
representative
subset
of
MSCs
periodontium,
explore
specific
role
immunopathology.
We
reveal
that
upon
challenging
an
inflammatory
microenvironment,
significantly
induce
rapid
trafficking
aberrant
activation
neutrophils
thus
exacerbating
alveolar
bone
resorption.
Mechanistically,
extracellular
vesicles
(EVs)
released
act
immune
regulators
tissue,
mediating
recruitment
through
increased
generation
reactive
oxygen
species
trigger
nuclear
factor
kappa-B
signaling.
Importantly,
inhibition
EV
release
from
or
pharmacological
therapy
using
GANT61
ameliorates
inflammation
loss.
Collectively,
our
findings
identify
previously
unrecognized
orchestrating
infiltration
priming
under
provide
pathological
insights
potential
therapeutic
targets
for
periodontitis.
Language: Английский
Neutrophils Suppress Osteogenic Differentiation of Gli1+ Stem Cells via Neutrophil Extracellular Traps and Contribute to Bone Loss in Periodontitis
Xinyue Cai,
No information about this author
Siyuan Fan,
No information about this author
Bingdong Sui
No information about this author
et al.
Biochemical and Biophysical Research Communications,
Journal Year:
2024,
Volume and Issue:
737, P. 150916 - 150916
Published: Oct. 30, 2024
Language: Английский