Facile One‐Pot Assembly of a Versatile Photoactive Nanozyme for Highly Efficient Antibacterial Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Conventional combinational antibacterial therapy requires the complicated assembly of multiple components that might cause a premature leak therapeutic agents. Thus one‐pot highly integrated multifunctional agents is desirable for treating multidrug‐resistant (MDR) bacteria. Herein, vancomycin‐derived carbon dots (Van‐CDs) are facilely developed as compact and powerful photodynamic nanozyme platform achieves augmented reactive oxygen species (ROS) generation accelerating bacterial elimination. By residual recognition groups vancomycin, red emissive Van‐CDs gain specific affinity toward bacteria with high binding constant 20 L g −1 , manifesting superior bacteria‐imaging ability. Meanwhile, encoded an excellent peroxidase‐mimicking (POD) activity mediating H 2 O ‐activated evolvement •OH, also endowed intrinsic property simultaneously producing singlet ( 1 ). Surprisingly, possesses auxiliary photothermal feature, which enables imaging‐guided hyperthermia‐reinforced in vivo. Furthermore, subcutaneous abscess model established to validate their pronounced biofilm eradication wound healing acceleration vivo through Van‐CDs‐promoted collagen deposition. Taken together, present all‐in‐one carbon‐derived functions represents promising competitive candidate diabetic infections clinical research.

Language: Английский

Interfacial Channel Design on the Charge Migration for PEC Applications

Chinese Journal of Structural Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100398 - 100398

Published: July 1, 2024

Language: Английский