Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
30, P. 101418 - 101418
Published: Dec. 25, 2024
Bone
graft
absorption
and
infection
are
the
major
challenges
to
guided
bone
regeneration(GBR),
yet
GBR
membrane
is
neither
osteogenic
nor
antibacterial.
Hence,
we
followed
sono-piezo
therapy
strategy
by
fabricating
an
electrospun
dispersed
with
boron
nitride
nanotubes.
The
PLLA/Gelatine/PDA@BNNT
(PGBT)
has
improved
mechanical
biocompatible
properties
generate
piezovoltages
of
130
mV
when
activated
ultrasound
stimulation
under
100
mW/cm2
without
extra
polarization.
PGBT
conducive
cellular
osteogenesis,
barrier
function,
shows
antibacterial
rate
about
40
%.
rat
cranial
defect
experiments
revealed
that
could
promote
osteogenesis
in-vivo
show
great
potentials
for
vertical
repair.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Low-intensity
ultrasound-mediated
sonodynamic
therapy
(SDT),
which,
by
design,
integrates
sonosensitizers
and
molecular
oxygen
to
generate
therapeutic
substances
(e.g.,
toxic
hydroxyl
radicals,
superoxide
anions,
or
singlet
oxygen)
at
disease
sites,
has
shown
enormous
potential
for
the
effective
treatment
of
a
variety
diseases.
Nanoscale
play
crucial
role
in
SDT
process
because
their
structural,
compositional,
physicochemical,
biological
characteristics
are
key
determinants
efficacy.
In
particular,
advances
materials
science
nanotechnology
have
invigorated
series
optimization
strategies
augmenting
efficacy
nanosonosensitizers.
This
comprehensive
review
systematically
summarizes,
discusses,
highlights
state-of-the-art
studies
on
current
achievements
nanosonosensitizer
enhanced
treatment,
with
an
emphasis
general
design
principles
nanosonosensitizers
strategies,
mainly
including
organic
inorganic
Additionally,
recent
advancements
optimized
applications
aimed
treating
various
diseases,
such
as
cancer,
bacterial
infections,
atherosclerosis,
autoimmune
clarified
detail.
Furthermore,
effects
improved
versatile
thoroughly
discussed.
The
concludes
highlighting
challenges
future
opportunities
this
rapidly
evolving
research
field
expedite
its
practical
clinical
translation
application.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Abstract
Diseases
caused
by
bacterial
infections
place
a
significant
burden
on
global
public
health.
Sonodynamic
therapy
(SDT),
as
an
emerging
antibacterial
treatment,
faces
clinical
challenges
due
to
the
non‐polar
nature
of
most
sonosensitizers.
To
address
this,
acid‐responsive
zinc‐porphyrin‐based
sonosensitizer
(Zn‐TCPP)
is
developed
via
simple
thermal
reaction,
which
then
coated
with
phenylboronic
acid‐modified
hyaluronic
acid
(B‐HA),
fabricate
B‐HA@Zn‐TCPP.
While
in
mildly
acidic
microenvironment
mimicking
infected
wound
site,
released
B‐HA@Zn‐TCPP
achieves
effective
SDT
activity.
The
disruption
membrane
and
levels
intracellular
reactive
oxygen
species
(ROS)
verified
that
inhibition
rate
can
reach
99%
within
5
min,
without
any
development
resistance
after
15
consecutive
generations
culture.
Additionally,
under
ultrasound
(US)
‐mediated
cavitation,
exhibits
excellent
penetration
into
biofilms,
achieving
90.04%
bactericidal
for
bacteria
biofilms.
In
vivo
studies
further
demonstrated
effectively
accelerate
healing
wounds
98.65%
9
days.
Therefore,
novel
offers
viable
strategy
overcome
limitations
traditional
sonosensitizers
infections.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Piezoelectric
semiconductor
nanomaterials
have
attracted
considerable
interest
in
piezocatalytic
tumor
treatment.
However,
therapy
encounters
obstacles
such
as
suboptimal
piezoelectric
responses,
rapid
electron‐hole
recombination,
inefficient
energy
harvesting,
and
the
complexities
of
microenvironment.
In
this
study,
sulfur
vacancy‐engineered
cobalt
(Co)
single‐atom
doped
molybdenum
disulfide
(SA‐Co@MoS
2
)
nanoflowers
are
strategically
designed,
which
exhibit
enhanced
effects.
Specifically,
introduction
Co
single
atom
not
only
induces
lattice
distortion
out‐of‐plane
polarization
but
also
leads
to
formation
numerous
vacancies.
These
changes
collectively
narrow
intrinsic
bandgap
material,
facilitating
effective
separation
migration
charge
carriers,
enabling
efficient
production
reactive
oxygen
species
under
ultrasound
stimulation.
Additionally,
SA‐Co@MoS
demonstrate
improved
enzymatic
activity
glutathione
depletion
capabilities
attributed
mixed
valence
states
Co,
intensifying
oxidative
stress
cells,
leading
cell
cycle
arrest
apoptosis,
while
inactivation
peroxidase
4
ferroptosis.
Both
vitro
vivo
results
indicate
that
can
significantly
eliminate
cells.
This
study
offers
valuable
insights
into
exploration
doping‐enhanced
sonosensitizers
for
cancer
treatment,
potentially
paving
way
advancements
field
synergistic
enzyodynamic
therapy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
Eliciting
ferroptotic
cell
death
in
tumors
has
enhanced
prospects
for
cancer
therapy
because
of
its
proinflammatory
properties,
which
enable
damage‐associated
molecular
pattern
(DAMP)
release
and
immune
response
activation.
However,
the
immunogenicity
ferroptosis
how
to
controllably
activate
self‐enhanced
antitumor
by
cellular
require
further
investigation.
In
this
study,
a
piezoelectric
BaTiO
3
‐based
inducer
(BTO@Fe)
is
synthesized
effective
immunotherapy.
BTO@Fe
induces
moderate
introducing
excess
iron
catalyzing
Fenton
reaction.
When
subjected
ultrasound
(US)
irradiation,
piezoelectrically
excited
electrons
holes
are
separated,
reactive
oxygen
species
(ROS)
generation
glutathione
(GSH)
consumption
consequently
causing
intensified
immunogenic
(ICD).
Moreover,
activated
CD8
+
T
cells
respond
signals
releasing
interferon
gamma
(IFNγ),
sensitizes
tumor
an
intrinsic
mechanism
initiation.
The
robust
originating
from
exogenous
piezocatalytic
reactions
endogenous
responses
demonstrates
satisfactory
vitro
vivo
effects.
This
work
suggests
that
doping‐engineered
materials
with
augmented
catalytic
activity
promising
countermeasures
restoring
cells.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 6, 2025
Abstract
Sonodynamic
therapy
(SDT)
is
a
promising
cancer
treatment
due
to
its
ability
utilize
ultrasound
(US)
activate
sonosensitizers,
generating
reactive
oxygen
species
(ROS)
for
tumor
suppression.
High‐valence
bismuth,
known
unique
photoacoustic
properties
and
biocompatibility,
has
shown
great
potential
when
combined
with
SDT.
However,
conventional
sonosensitizers
large
bandgaps
electron‐hole
recombination
have
limited
SDT's
effectiveness.
Herein,
bismuth‐based
piezoelectric
sonosensitizer
developed,
DSPE‐PEG
2000‐modified
KBiO
3
(KBP),
which
features
reduced
bandgap
(1.9
eV).
This
facilitates
electron
transfer
depletes
glutathione
in
the
microenvironment.
Under
US,
KBP
generates
significant
amount
of
ROS,
leading
cell
pyroptosis
via
ROS‐NLRP3‐Caspase‐1‐GSDMD
pathway.
Both
vitro
vivo
experiments
demonstrated
that
SDT
can
effectively
inhibit
growth.
research
offers
novel
approach
by
leveraging
advantages
SDT,
demonstrating
clinical
inhibition.
