ATP-Responsive ZIF-based NIR Fluorescent Nanosystem for Enhanced Chemo-Photodynamic Therapy of Tumors DOI
Sisi Chen,

Xiao-Fan Xu,

Wei-Qun Deng

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An ATP-responsive fluorescence nanosystem for chemo-photodynamic therapy is reported. The can avoid premature drug leakage and enhance local delivery.

Language: Английский

Nanoparticle‐Mediated Cuproptosis and Photodynamic Synergistic Strategy: A Novel Horizon for Cancer Therapy DOI Creative Commons
Junrui Zhang,

Anren Zhang,

Yibing Guo

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: Jan. 27, 2025

Photodynamic therapy (PDT) is a noninvasive cancer treatment that works by using light to stimulate the production of excessive cytotoxic reactive oxygen species (ROS), which effectively eliminates tumor cells. However, therapeutic effects PDT are often limited hypoxia, prevents effective cell elimination. The (O2) consumption during can further exacerbate leading post-treatment adverse events. This review aims explore potential cuproptosis, recently discovered copper-dependent form programmed death, enhance anticancer PDT. Cuproptosis highly dependent on mitochondrial respiration, specifically tricarboxylic acid (TCA) cycle, and increase O2 ROS levels or decrease glutathione (GSH) levels, thereby improving outcomes. discusses latest research advancements in field, detailing mechanisms regulate cuproptosis It also explores how nanoparticle (NP)-based strategies be used exploit synergistic between article examines prospects activity guided nanodelivery systems, could overcome challenges associated with hypoxia treatment. combination PDT, facilitated NP-based delivery presents promising approach effectiveness therapy. concludes discussing future directions for this therapy, highlighting need investigation into optimization improve outcomes

Language: Английский

Citations

1
A "Building-Block" Strategy for Porphyrin-Based Two-Photon Photosensitizers Dual-Targeting Cancer Cells and Subcellular Organelles DOI

Chaorui Su,

Peipei Xing,

Jinghui Zhang

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112759 - 112759

Published: March 1, 2025

Language: Английский

Citations

0
ATP-Responsive ZIF-based NIR Fluorescent Nanosystem for Enhanced Chemo-Photodynamic Therapy of Tumors DOI
Sisi Chen,

Xiao-Fan Xu,

Wei-Qun Deng

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An ATP-responsive fluorescence nanosystem for chemo-photodynamic therapy is reported. The can avoid premature drug leakage and enhance local delivery.

Language: Английский

Citations

1