A Review of Basic Fibroblast Growth Factor Delivery Strategies and Applications in Regenerative Medicine DOI

Yuhan Tu,

Yang Li,

Gao-Er Qu

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 113(1)

Published: Dec. 30, 2024

Basic fibroblast growth factor (bFGF) is a significant member of the (FGF) family. The bFGF has three-dimensional structure comprising 12 reverse parallel β-folds. This facilitates tissue wound repair, angiogenesis, bone formation, cartilage and nerve regeneration. Consequently, it garnered attention from scholars both domestically internationally. However, instability degradation properties in vivo have limited its clinical application. Significant interest arisen development novel delivery systems that can address shortcomings enhance bioavailability by controlling release amount, timing, location. article offers comprehensive overview research recent advances various systems, including hydrogels, liposomes, microspheres, nanoparticles. Subsequently, applications pharmaceutical preparations fields are described. Finally, current drug formulations those trials discussed, along with their translation future trends.

Language: Английский

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives DOI Creative Commons
Cheng Han, Jiao Jiao, Chan Gong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский

Citations

0
Biomaterial-mediated delivery of traditional Chinese medicine ingredients for spinal cord injury: a systematic review DOI Creative Commons
Gang Liu,

Zhenzhen Pei,

Huizhong Bai

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

Biomaterials loaded with ingredients derived from traditional Chinese medicine (TCM) are viewed as a promising strategy for treating spinal cord injury (SCI). However, comprehensive analysis of the existing literature on this topic has not yet been conducted. Therefore, paper systematically reviews researches related to approach, aiming identify gaps and shortcomings in field. PubMed, EMBASE, Web Science, Biomedical Literature, Wanfang, China National Knowledge Infrastructure (CNKI) were searched retrieving studies biomaterials TCM published their inception October 2024. Two reviewers performed screening search results, information extraction, quality assessment independently. For systematic review, 41 publications included. Six ingredients-paclitaxel, curcumin, tetramethylpyrazine, resveratrol, berberine, tanshinone IIA combined treatment SCI. categorized into hydrogels, biodegradable scaffolds, nanoparticles, microspheres according type scaffold. These drug delivery systems exhibit commendable biocompatibility, drug-loading capacity, drug-release capabilities, combination ingredients, synergistically contribute anti-oxidative stress, anti-inflammatory, neuroprotective, anti-apoptotic effects. demonstrated efficacy facilitating motor function recovery neuroprotection SCI rats, providing evidence future research. complex microenvironment SCI, achieving maximum loading capacity within biomaterials, along sustained controlled release fully exert pharmacological effects, remains major challenge https://www.crd.york.ac.uk/PROSPERO/ identifier CRD42024505000.

Language: Английский

Citations

3
A Review of Basic Fibroblast Growth Factor Delivery Strategies and Applications in Regenerative Medicine DOI

Yuhan Tu,

Yang Li,

Gao-Er Qu

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 113(1)

Published: Dec. 30, 2024

Basic fibroblast growth factor (bFGF) is a significant member of the (FGF) family. The bFGF has three-dimensional structure comprising 12 reverse parallel β-folds. This facilitates tissue wound repair, angiogenesis, bone formation, cartilage and nerve regeneration. Consequently, it garnered attention from scholars both domestically internationally. However, instability degradation properties in vivo have limited its clinical application. Significant interest arisen development novel delivery systems that can address shortcomings enhance bioavailability by controlling release amount, timing, location. article offers comprehensive overview research recent advances various systems, including hydrogels, liposomes, microspheres, nanoparticles. Subsequently, applications pharmaceutical preparations fields are described. Finally, current drug formulations those trials discussed, along with their translation future trends.

Language: Английский

Citations

0