A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 404 - 416

Published: Feb. 10, 2025

Language: Английский

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Colorful photothermal photonic crystal cotton fabric based on melanin-like polycaffeic acid nanoparticles

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141056 - 141056

Published: Feb. 1, 2025

Language: Английский

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Robust Injectable Hydrogels for Hemophilic Arthropathy via Anti‐Inflammation, Iron Removal and Cartilage Protection

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Hemophilic arthropathy (HA), a form of arthritis associated with joint bleeding, presents extra challenges in treatment due to intermittent bleeding‐induced iron‐overloading, oxidative stress, and inflammation. Conventional therapeutic approaches have predominantly concentrated on achieving hemostasis reducing inflammation, yet they fallen short effectively managing iron overload safeguarding cartilage, resulting less‐than‐ideal outcomes. To address these issues, series injectable hydrogels is facilely fabricated via one‐step assembly polyphenols, chelators, lipoic acid. In vitro investigations demonstrate that the not only good performances antioxidation anti‐inflammation, but also exhibit promising prospects removal, adhesion resistance, wear resistance. Moreover, vivo studies are further carried out indicate diminished inflammatory response, ameliorative iron‐overload‐related lesion indicators, cartilage preservation. This class robust multifunctional composed clinically available drugs along commonly used commercial ingredients would offer new opportunities toward efficient HA.

Language: Английский

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Carbon Nanodots-Integrated Multifunctional Nanomedicine Establishes a Regenerative Feedback Loop between Vascular-Immune-Muscle Systems for Comprehensive Therapy of Critical Limb Ischemia

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Critical limb ischemia (CLI) remains a major clinical challenge, with high amputation and mortality rates. Dysregulated intercellular interactions among vascular, immune, muscle systems in CLI undermine the body's repair processes. Herein, multiactive nanomedicine, CDs@Zn@l-Arg, was developed by integrating Panax notoginseng saponin-derived carbon nanodots (CDs-PNS), zinc ions, l-arginine to induce mutually supportive cycle of angiogenesis, macrophage reprogramming, regeneration. CDs-PNS, first identified for their potent antioxidative, angiogenic, macrophage-reprogramming properties therapy, are further enhanced leveraging zeolitic imidazolate frameworks as mediators physically encapsulate them, while is incorporated through electrostatic binding Schiff base reactions. Individual cell culture experiments demonstrate that, integration various bioactive components, CDs@Zn@l-Arg effectively promotes endothelial tube formation myosatellite proliferation reduces inflammation oxidative stress. More importantly, coculture models reveal that successfully reverses detrimental typical CLI, thereby enhancing positive crosstalk between cells, macrophages, cells. In mouse model, treatment significantly improves blood perfusion, inflammation, accelerates function recovery. Altogether, establishing regenerative feedback loop vascular-immune-muscle system, this nanomedicine holds promise overcoming multifaceted challenges providing breakthrough strategy integrated therapy.

Language: Английский

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Tannic Acid Film Based on One-Dimensional Supramolecular Self-Assembly for Electrical Conductivity and Oil–Water Separation

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 57596 - 57602

Published: Oct. 8, 2024

Tannic acid is widely regarded as one of the most promising natural polyphenolic compounds. However, current research predominantly focuses on utilization its phenolic hydroxyl groups, with limited exploration functional potential aromatic structure. Herein, one-dimensional nanofibers based supramolecular self-assembly were successfully prepared through simple alkylation reaction tannic and π–π stacking structures. These fibers, lengths reaching tens micrometers an average height 10 nm, clearly observed using SEM AFM. A film excellent electrical conductivity (σ = 37.9 μS/cm) was fabricated by vacuum filtering organic suspension these which 100-fold higher than that TA film. Additionally, hydrophobic lipophilic properties Bn-TA further investigated oil–water separation experiments, where membrane displayed efficiency durability, maintaining stable performance over multiple cycles. This strategy presents opportunities for high-value acid.

Language: Английский

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Preparation of Pla-Ppt Micro-Nanocomposites Via One-Step Emulsion Technique: Enhanced Antioxidative Properties and Biocompatibility

Published: Jan. 1, 2024

Language: Английский

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