Unveiling ferroptosis: a new frontier in skin disease research

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

Enhancing the Safety and Efficacy of Trastuzumab Emtansine (T‐DM1) Through Nano‐Delivery System in Breast Cancer Therapy

Small, Journal Year: 2024, Volume and Issue: 20(50)

Published: Oct. 6, 2024

Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, revolutionizes breast cancer therapy by specifically delivering DM1 to human epidermal growth factor receptor 2 (HER2) overexpressing tumor cells, effectively inhibiting cell division and proliferation. While T-DM1 demonstrates superior efficacy tolerability, T-DM1-induced thrombocytopenia remains a significant adverse event leading treatment discontinuation. To address this issue, the study investigates feasibility of using poly(lactic-co-glycolic acid) (PLGA) nanoparticles as delivery vehicle conjugate T-DM1, aiming alleviate thrombocytopenia. The T-DM1-conjugated PLGA (NPs-T-DM1) reduce binding megakaryocytes without compromising targeting ability for HER2. Administration NPs-T-DM1 not only significantly inhibits but also reduces damage megakaryocytes, thrombocytopenia, remarkably improves safety antibody-conjugated drugs. This work presents promising strategy enhance in antitumor therapy, offering potential advancing clinical application HER2-positive patients.

Language: Английский

Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137776 - 137776

Published: Nov. 1, 2024

Language: Английский