Biocatalytic Clusterzyme Patches Restore Lung Function via Immunomodulation and Mitochondria Protection DOI
Wei Liu,

Sufei Zhou,

Ke Yang

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Currently, pulmonary complications such as lung infections during the perioperative period are still main cause of prolonged hospitalization and death in patients with injury due to lack effective drugs. Clusterzyme, a kind artificial enzyme high enzyme-like activity safety profile, exhibits good effects on reducing oxidative stress immunomodulation. Here, we present functionalized patches that is administered airways rescues injured organ via clusterzymes. The long-term antioxidant capacity significantly ameliorated lipopolysaccharide-induced function impairment significant reduction goblet cell metaplasia stress. inflammatory factors cytokines interleukin-1β, interleukin-6, tumor necrosis factor-α levels decreased by 50%, while mtDNA copy number increased 50% ATP production 100%. Mice was improved, suggesting can rescue modulating immune responses well protecting mitochondria, providing an avenue for intervention injury.

Language: Английский

Biocatalytic Clusterzyme Patches Restore Lung Function via Immunomodulation and Mitochondria Protection DOI
Wei Liu,

Sufei Zhou,

Ke Yang

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Currently, pulmonary complications such as lung infections during the perioperative period are still main cause of prolonged hospitalization and death in patients with injury due to lack effective drugs. Clusterzyme, a kind artificial enzyme high enzyme-like activity safety profile, exhibits good effects on reducing oxidative stress immunomodulation. Here, we present functionalized patches that is administered airways rescues injured organ via clusterzymes. The long-term antioxidant capacity significantly ameliorated lipopolysaccharide-induced function impairment significant reduction goblet cell metaplasia stress. inflammatory factors cytokines interleukin-1β, interleukin-6, tumor necrosis factor-α levels decreased by 50%, while mtDNA copy number increased 50% ATP production 100%. Mice was improved, suggesting can rescue modulating immune responses well protecting mitochondria, providing an avenue for intervention injury.

Language: Английский

Citations

0