Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Large
bone
defects,
often
arising
from
trauma
or
infection,
pose
a
considerable
therapeutic
challenge
due
to
their
limited
capacity
for
spontaneous
healing,
thus
requiring
graft
materials
effective
reparative
procedures.
The
persistence
of
inflammation
and
elevated
levels
reactive
oxygen
species
(ROS)
within
these
defect
sites
significantly
impede
regeneration
process.
Addressing
this,
an
injectable
hydrogel
system
with
ROS-responsive
functionality
is
developed,
specifically
tailored
the
high
ROS
microenvironment
characteristic
defects.
This
incorporates
hyaluronic
acid
functionalized
dopamine
introduce
catechol
moieties,
employs
4-formylphenylboronic
as
crosslinking
agent
form
dynamic
matrix
(HAC)
carboxymethyl
chitosan.
HAC
serves
carrier
dimethyl
fumarate
(DMF),
compound
established
anti-inflammatory
antioxidant
effects,
enabling
its
controlled
release
in
response
levels.
Herein,
we
investigated
physicochemical
properties
DMF
loaded
(DHAC)
by
microstructure
observation,
vitro
degradation
assay,
self-healing
test,
injectability
experiments,
drug
assay.
Meanwhile,
systematically
effects
on
inflammation,
intracellular
ROS,
osteogenesis.
Consequently,
DHAC
reduced
pro-inflammatory
cytokines
secreted
RAW264.7
cells
scavenged
MC3T3
cells.
effect
was
accompanied
augmentation
osteogenic
potential
promotion
repair
cranial
defects
rats.
DHAC,
which
exhibits
anti-inflammatory,
antioxidant,
activity,
hold
great
strategy
management
large
STATEMENT
OF
SIGNIFICANCE:
Here,
novel
fumarate-loaded
developed
treatment
Our
findings
demonstrated
that
not
only
promotes
but
also
controls
addressing
two
critical
challenges
healing.
Comprehensive
evaluations
show
significant
improvements
formation
reduction
animal
models.
Additionally,
excellent
scavenging
ability,
effectively
modulating
oxidative
stress
microenvironment.
Findings
suggest
may
serve
promising
clinical
critical-sized
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 190 - 190
Published: March 8, 2025
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
bone
defect
repair
due
to
their
excellent
biocompatibility,
high
porosity,
and
water-retentive
properties.
However,
conventional
face
significant
challenges
in
clinical
translation,
including
brittleness,
low
mechanical
strength,
poorly
controlled
drug
degradation
rates.
To
address
these
limitations,
a
multifunctional
polymer,
polydopamine
(PDA)
has
shown
great
potential
both
regeneration
delivery
systems.
Its
robust
adhesive
properties,
responsiveness
photothermal
stimulation
make
it
an
ideal
candidate
enhancing
hydrogel
performance.
Integrating
PDA
into
not
only
improves
properties
but
also
creates
environment
conducive
cell
adhesion,
proliferation,
differentiation,
thereby
promoting
repair.
Moreover,
facilitates
release,
offering
approach
optimizing
treatment
outcomes.
This
paper
first
explores
the
mechanisms
through
which
promotes
regeneration,
laying
foundation
its
translation.
Additionally,
discusses
application
of
PDA-based
nanocomposite
advanced
systems
repair,
providing
valuable
insights
research
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101687 - 101687
Published: March 20, 2025
Repairing
bone
defects
in
inflammatory
conditions
remains
a
significant
clinical
challenge.
An
ideal
scaffold
material
for
such
situations
should
enable
minimally
invasive
implantation
and
integrate
capabilities
immunomodulation,
anti-infection
therapy,
enhanced
regeneration.
In
this
study,
we
developed
injectable
calcitriol@polydopamine@gelatin
methacryloyl
hydrogel
microspheres
(CAL@PDA@GMs)
using
microfluidic
technology.
This
system
facilitates
the
sustained
release
of
calcitriol,
which
features
excellent
biocompatibility
biodegradability,
promotes
osteogenesis,
scavenges
excessive
reactive
oxygen
species
(ROS),
induces
polarization
macrophages
from
M1
to
M2
phenotype,
thereby
mitigating
lipopolysaccharide
(LPS)-induced
inflammation.
These
mechanisms
work
synergistically
create
an
optimal
immune
microenvironment
regeneration
conditions.
RNA
sequencing
(RNA-Seq)
analyses
revealed
that
immunomodulation
is
achieved
by
regulating
macrophage
phenotypes,
inhibiting
nuclear
transcription
factor-kappa
B
(NF-κB)
ROS
signaling
pathways,
reducing
secretion
pro-inflammatory
cytokines.
study
proposes
novel
method
enhance
tissue
remediating
damaged
presents
potential
therapeutic
strategy
large-scale
injuries.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
An
ideal
guided
bone
regeneration
(GBR)
membrane
for
periodontitis
treatment
should
incorporate
biocompatibility,
biodegradability,
mechanical
strength,
antibacterial
properties,
and
osteoconductivity.
However,
no
commercially
available
GBR
meets
all
these
criteria
simultaneously.
In
this
study,
a
novel
biodegradable
piezoelectric
double-layered
is
developed,
with
non-piezoelectric
Poly-L-lactic
acid
(PLLA)
side
facing
the
gingiva
PLLA-ZnO
alveolar
bone.
This
asymmetric
membrane,
distinct
fiber
orientations
charge
distribution,
combines
synergizes
degradability,
barrier
function,
activity
osteogenic
potential
to
enhance
efficacy.
The
can
effectively
prevent
fibroblast
migration,
inhibits
bacterial
infection,
promotes
both
in
vitro
vivo.
testing
shows
good
rate
against
Porphyromonas
gingivalis
(P.
gingivalis)
Staphylococcus
aureus
(S.
aureus)
after
10
min
of
ultrasound
stimulation.
Expression
levels
genes
Bone
morphogenetic
Protein
2
(BMP2),
Runt-related
transcription
factor
(RUNX2),
Osteopontin
(OPN)
Osteocalcin
(OCN)
are
over
twice
that
control.
mouse
P.
gingivalis-mediated
model,
our
composite
demonstrates
effective
antimicrobial
effects
promote
2-
4-weeks
implantation,
facilitated
by
mechanisms
such
as
physical
isolation,
zinc
ion
release,
effects,
enhanced
expression
through
activation
osteogenesis-related
signaling
pathways,
underscoring
its
strong
applications.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Abstract
The
distinctive
structure
and
composition
of
the
Haversian
canal
within
osteons
play
a
pivotal
role
in
sustaining
nutritional
supply
to
individual
bone
cells.
Consequently,
osteon's
inherent
advantages
facilitating
repair
have
garnered
increasing
attention.
However,
most
existing
designs
emulate
only
partial
aspects
architecture,
failing
replicate
its
functionality
comprehensively.
This
study
aimed
develop
functional
3D
biomimetic
osteon
enhance
regeneration.
To
achieve
this,
oriented
nanofibers
mimicking
osteonal
lamellae
are
fabricated
via
electrospinning,
while
blood
vessel,
simulating
canal,
is
constructed
using
microfluidics
technology.
vessels,
seeded
with
rat
umbilical
vein
endothelial
cells,
secreted
morphogenetic
protein
stimulate
osteogenesis
released
platelet‐derived
growth
factor
promote
angiogenesis,
further
supporting
processes.
nanofibers,
composed
type
I
collagen
nano‐hydroxyapatite,
calcium
ions,
can
facilitate
recruitment
marrow
mesenchymal
stem
their
adhesion
fibers,
osteogenic
differentiation.
These
findings
demonstrate
that
replicating
both
natural
function
tissue
provides
superior
strategy
for
repair.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
MXenes-based
composite
materials,
as
emerging
two-dimensional
have
shown
extensive
potential
in
the
biomedical
field
due
to
their
excellent
electrical,
mechanical,
and
surface
properties.
MXenes
possess
diverse
chemistry
that
enables
interactions
with
a
variety
of
biomolecules,
promoting
innovations
drug
delivery,
cellular
imaging,
cancer
therapy,
more.
By
combining
various
biomaterials
such
polymers,
metal
nanoparticles,
carbon
performance
is
further
enhanced,
improving
biocompatibility,
stability,
functionality.
These
materials
demonstrated
significant
promise
cancer-targeted
tissue
engineering,
sensor
development,
antimicrobial
treatment.
This
chapter
summarizes
latest
advancements
applications
composites
discusses
challenges
future
directions
for
development.
Host
immune
rejection
has
long
been
recognized
as
a
major
contributor
to
the
poor
survival
rates
of
exogenous
stem
cells
(ESCs).
In
this
study,
we
present
simple
and
versatile
strategy
protect
ESCs
from
host
system
insults
by
developing
protective
"armor."
This
armor
was
designed
using
tannic
acid
(TA),
leveraging
its
strong
affinity
for
biomacromolecules
anti-inflammatory
properties.
Prior
implantation,
can
be
readily
applied
surface
individual
ESCs,
cell
aggregates,
sheets,
or
cell-laden
hydrogel
systems
simply
immersing
them
in
TA
solution
several
seconds,
without
additional
processing
steps.
The
TA-based
effectively
modulates
acute
inflammatory
response
during
initial
days
postimplantation
scavenging
reactive
oxygen
species
(ROS),
thereby
creating
an
ESCs-friendly
microenvironment.
evidenced
reduction
infiltration
pro-inflammatory
secretion
cytokines.
Consequently,
engrafted
significantly
enhanced,
with
preserved
stemness
immunomodulatory
functions.
regenerative
potential
further
demonstrated
rat
periodontal
defect
model.
These
findings
provide
novel
approach
enhancing
performance
offer
straightforward
shield
rejection.
