A Microenvironment-Adaptive GelMA-ODex@RRHD Hydrogel for Responsive Release of H2S in Promoted Chronic Diabetic Wound Repair DOI Creative Commons

Zhixian Yuan,

Wei Zhang, Chang Wang

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 23, 2024

Abstract Chronic diabetic wounds present significant treatment challenges due to their complex microenvironment, often leading suboptimal healing outcomes. Hydrogen sulfide (H2S), a crucial gaseous signaling molecule, has shown great potential in modulating inflammation, oxidative stress and extracellular matrix remodeling, which are essential for effective wound healing. However, conventional H2S delivery systems lack the adaptability required meet dynamic demands of different stages, thereby limiting therapeutic efficacy. To address this, we developed an injectable, ROS-responsive donor system integrated within gelatin methacryloyl (GelMA) hydrogel matrix, forming double-network (GelMA-ODex@RRHD). The injectability this allows minimally invasive application, conforming closely contours ensuring uniform distribution. incorporation oxidatively modified dextran derivatives (ODex) not only preserves biocompatibility but also enables chemical attachment donors. GelMA-ODex@RRHD releases response stress, optimizing environment cell growth, macrophage polarization supporting vascular regeneration. This innovative material effectively suppresses inflammation during initial phase, promotes tissue regeneration proliferative phase facilitates controlled remodeling later ultimately enhancing closure functional recovery. released by expedited process improved biomechanical characteristics newborn skin mice, particularly terms stiffness elasticity. enhancement resulted quality being more similar normal process. By aligning with natural process, approach offers promising pathway toward personalized treatments chronic wounds.

Language: Английский

Antibacterial carbon dots DOI Creative Commons
Shuaishuai Wang, Dapeng Wang, Guoliang Wang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101383 - 101383

Published: Dec. 6, 2024

Language: Английский

Citations

5
Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex DOI Creative Commons
Ziwei Wang, Bo Zhu, Wei Nie

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Conventional therapy to treat thrombi (blood clots) has significant limitations: i) inflammation; ii) bleeding side effects; iii) re-embolisation, and iv) in situ that are not visible. Here it is reported Cu2Ir nanoparticles (NPs) with a Cu-coordinated tetraphenylporphyrin (TPP) core cyclometalated Ir(C^N)2(N^N) substituents integrate long-lived near-infrared (NIR) chemiluminescence (CL) imaging, photothermal (PTT) photodynamic (PDT) for thrombolysis, antioxidant anti-inflammatory properties. Based on density functional theory calculations the chemiluminescent reaction site between TPP peroxynitrite (ONOO-) confirmed first time. The presence of transition metal significantly improves properties TPP. Upon specific activation by ONOO-, NPs exhibited more than 30-fold NIR CL intensity NPs, luminescence lasted 60 min allowing precise long-lasting dynamic tracking thrombi. achieved non-invasive safe thrombolytic triggered irradiation at signaling site. 72.3% blood reperfusion obtained nearly complete restoration flow, re-embolism prevented mouse carotid artery model. Furthermore, scavenged excess reactive oxygen/nitrogen species (RONS) reduced inflammatory factors. hold promise as single-molecule strategy diagnosing treating diseases associated thrombosis.

Language: Английский

Citations

0
A Single H2S-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention DOI
Ying Yin, Wentai Guo,

Q Y Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive environments, such as hyperglycemia, bacterial infection, impaired angiogenesis. However, current are complicated need on-demand sequential release synergy of multicomponents. Herein, H2S-releasing cascade nanozyme (FeS@Au), which is composed ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), developed single component regulate glucose level, eliminate promote angiogenesis, achieving for diabetic treatment. The oxidase-like activity AuNC catalyzes into gluconic acid H2O2, not only lowers the local level but also decreases pH increases H2O2 boost peroxidase-like FeSNP generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, H2S acidified environment upregulate hypoxia-inducible factor-1 enhance vascularization through upregulating expression vascular endothelial growth factor (VEGF) other angiogenesis-related genes, reducing damage cells caused by excessive ROS produced nanozyme. In full-thickness MRSA-infected rat model, FeS@Au significantly eliminates bacteria, enhances promotes collagen deposition, accelerates healing. This work with H2S-release interventions, providing versatile strategy extensive tissue diabetes.

Language: Английский

Citations

0
A Microenvironment-Adaptive GelMA-ODex@RRHD Hydrogel for Responsive Release of H2S in Promoted Chronic Diabetic Wound Repair DOI Creative Commons

Zhixian Yuan,

Wei Zhang, Chang Wang

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 23, 2024

Abstract Chronic diabetic wounds present significant treatment challenges due to their complex microenvironment, often leading suboptimal healing outcomes. Hydrogen sulfide (H2S), a crucial gaseous signaling molecule, has shown great potential in modulating inflammation, oxidative stress and extracellular matrix remodeling, which are essential for effective wound healing. However, conventional H2S delivery systems lack the adaptability required meet dynamic demands of different stages, thereby limiting therapeutic efficacy. To address this, we developed an injectable, ROS-responsive donor system integrated within gelatin methacryloyl (GelMA) hydrogel matrix, forming double-network (GelMA-ODex@RRHD). The injectability this allows minimally invasive application, conforming closely contours ensuring uniform distribution. incorporation oxidatively modified dextran derivatives (ODex) not only preserves biocompatibility but also enables chemical attachment donors. GelMA-ODex@RRHD releases response stress, optimizing environment cell growth, macrophage polarization supporting vascular regeneration. This innovative material effectively suppresses inflammation during initial phase, promotes tissue regeneration proliferative phase facilitates controlled remodeling later ultimately enhancing closure functional recovery. released by expedited process improved biomechanical characteristics newborn skin mice, particularly terms stiffness elasticity. enhancement resulted quality being more similar normal process. By aligning with natural process, approach offers promising pathway toward personalized treatments chronic wounds.

Language: Английский

Citations

0