Constructing a hierarchical composite scaffold with a honeycomb-like micro-network for bone regeneration using a one-step freeze-casting strategy

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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The Role of Magnesium, Zinc, and Strontium in Osteoporotic Fracture Repair

Bioengineering, Journal Year: 2025, Volume and Issue: 12(2), P. 201 - 201

Published: Feb. 18, 2025

Osteoporotic fractures represent a significant public health challenge in the context of an aging global population, with rising prevalence osteoporosis intensifying demand for effective fracture treatment. Restoring structure and function bone tissue damaged by osteoporosis-induced defects remains critical issue clinical practice. In recent years, bioactive metallic materials such as magnesium, zinc, strontium have gained considerable attention due to their exceptional mechanical properties, biocompatibility, biodegradability, positioning them promising osteoporotic repair. This review systematically explored biological mechanisms, application advancements, associated challenges healing. Key topics included roles promoting osteoblast proliferation differentiation, inhibiting osteoclast activity, modulating microenvironment. Additionally, this examined optimization strategies application, integration into scaffolds, functionalization conventional materials, synergistic effects between different metals. Finally, analyzed current progress unresolved issues field, offering forward-looking perspective on potential precision treatment fractures.

Language: Английский

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Mg-Co double hydroxide/lactoferrin composite coating on Ti-based orthopedic implants: A pioneering strategy for augmenting bone defect restoration

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 308, P. 142489 - 142489

Published: March 26, 2025

Language: Английский

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Injectable Hydrogel Technologies for Bone Disease Treatment

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies their biocompatibility, adjustable mechanical properties, capacity to respond external stimuli, including pH, temperature, light, redox potential, ionic strength, enzymatic activity. These features enable enhanced targeted bioactive agents. This mini-review evaluates synthesis injectable well recent advancements treating range bone disorders, focusing on mechanisms sustained DDSs delivering drugs, nanoparticles, growth factors, cells (e.g., stem cells). Moreover, it highlights clinical studies disease treatment. Additionally, emphasizes potential synergy between hydrogel-based point-of-care technologies, which are anticipated play pivotal role future therapies. have transform treatment by facilitating precise, sustained, minimally invasive therapeutic delivery. Nevertheless, significant challenges, long-term scalability, reproducibility, precise regulation release kinetics, must be addressed unlock fully. Addressing these challenges will not only advance therapy but also open new avenues regenerative medicine personalized healthcare.

Language: Английский

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Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 195 - 212

Published: Dec. 14, 2024

Language: Английский

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