Green biosynthesis of titanium dioxide nanoparticles incorporated gellan gum hydrogel for biomedical application as wound dressing DOI Creative Commons
Ying Su,

Xiaoxue Zhu,

Guangqi Xu

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 17, 2025

Titanium dioxide nanoparticles (TiO 2 NPs) are widely synthesized chemically for industrial applications. However, these methods often have negative environmental impacts, rendering them unsuitable biomedical Green synthesis approaches offer a promising alternative due to their simplicity, friendliness, and cost-effectiveness. In this study, we report the biosynthesis of TiO NPs using Morus alba leaf extract subsequent incorporation into gellan gum (GG) biopolymer create hydrogel. The physicochemical properties biosynthesized NP@GG hydrogel were characterized Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive (EDS), photoelectron (XPS). Furthermore, bioactivity materials was investigated through antibacterial assays against Staphylococcus aureus Escherichia coli , as well in vitro wound healing studies 3T3 fibroblast scratch assay. XRD analysis confirmed successful formation anatase phase . SEM images revealed presence irregular rod-shaped nanoparticles, with EDS confirming composition oxygen titanium. particle size determined be 80–90 nm, exhibited homogeneous distribution throughout network. displayed significant activity both S. E. assay on cells seeded onto demonstrated high cell survival rate enhanced migration, suggesting potential applications dressing material.

Language: Английский

Cytotoxic Effects of ZnO and Ag Nanoparticles Synthesized in Microalgae Extracts on PC12 Cells DOI Creative Commons
Giacomo Fais, Agnieszka Sidorowicz,

Graziella Perra

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(12), P. 549 - 549

Published: Dec. 4, 2024

The green synthesis of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs), as well Ag/Ag2O/ZnO nanocomposites (NCs), using polar apolar extracts Chlorella vulgaris, offers a sustainable method for producing nanomaterials with tunable properties. impact the environment nanomaterials’ characteristics on cytotoxicity was evaluated by examining reactive species production their effects mitochondrial bioenergetic functions. Cytotoxicity assays PC12 cells, cell line originated from rat pheochromocytoma, an adrenal medulla tumor, demonstrated that Ag/Ag2O NPs synthesized (Ag/Ag2O A) P) exhibited significant cytotoxic effects, primarily driven Ag+ ion release disruption function. However, it is more likely organic content, rather than size, influenced anticancer activity, commercial Ag NPs, despite smaller crystallite sizes, exhibit less effective activity. ZnO P showed increased oxygen (ROS) generation, correlated higher cytotoxicity, while A produced lower ROS levels, resulting in diminished effects. comparative analysis revealed differences LD50 values toxicity profiles. Differentiated cells resistance to ZnO, AgNPs Ag/Ag2O-based materials had similar both types. This study emphasizes crucial role bioactive compounds C. vulgaris modulating nanoparticle surface chemistry, cytotoxicity. results provide valuable insights designing safer biomedical applications, especially targeting tumor-like exploring relationships between polarity, capping agents, nanocomposite structures.

Language: Английский

Citations

6
How can membrane lipid constituency be manipulated to produce liposomes with desired functions? DOI Creative Commons
Travis Issler,

Sonja Lisowski,

Kianmehr Farzi

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: Feb. 24, 2025

Language: Английский

Citations

0
Green biosynthesis of titanium dioxide nanoparticles incorporated gellan gum hydrogel for biomedical application as wound dressing DOI Creative Commons
Ying Su,

Xiaoxue Zhu,

Guangqi Xu

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 17, 2025

Titanium dioxide nanoparticles (TiO 2 NPs) are widely synthesized chemically for industrial applications. However, these methods often have negative environmental impacts, rendering them unsuitable biomedical Green synthesis approaches offer a promising alternative due to their simplicity, friendliness, and cost-effectiveness. In this study, we report the biosynthesis of TiO NPs using Morus alba leaf extract subsequent incorporation into gellan gum (GG) biopolymer create hydrogel. The physicochemical properties biosynthesized NP@GG hydrogel were characterized Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive (EDS), photoelectron (XPS). Furthermore, bioactivity materials was investigated through antibacterial assays against Staphylococcus aureus Escherichia coli , as well in vitro wound healing studies 3T3 fibroblast scratch assay. XRD analysis confirmed successful formation anatase phase . SEM images revealed presence irregular rod-shaped nanoparticles, with EDS confirming composition oxygen titanium. particle size determined be 80–90 nm, exhibited homogeneous distribution throughout network. displayed significant activity both S. E. assay on cells seeded onto demonstrated high cell survival rate enhanced migration, suggesting potential applications dressing material.

Language: Английский

Citations

0