Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123027 - 123027
Published: Dec. 15, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
The article provides an overview of the current understanding interplay between metabolic pathways and immune function in context triple-negative breast cancer (TNBC). It highlights recent advancements single-cell spatial transcriptomics technologies, which have revolutionized analysis tumor heterogeneity microenvironment TNBC. review emphasizes crucial role reprogramming modulating cell function, discussing how specific pathways, such as glycolysis, lipid metabolism, amino acid can directly impact activity phenotypes various populations within TNBC microenvironment. Furthermore, explores implications these metabolic-immune interactions for efficacy checkpoint inhibitor (ICI) therapies TNBC, suggesting that strategies targeting may enhance responsiveness to ICI treatments. Finally, outlines future directions potential combination integrate modulation with immunotherapeutic approaches, offering promising avenues improving clinical outcomes patients.
Language: Английский
Citations
2
Advanced Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.
Language: Английский
Citations
1
Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637
Published: March 1, 2025
Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 7, 2025
Abstract Breast cancer is the most commonly diagnosed worldwide. Despite advancements in therapeutic modalities, its prognosis remains poor owing to complex clinical, pathological, and molecular characteristics. Sonodynamic therapy (SDT) a promising approach for tumor elimination, using sonosensitizers that preferentially accumulate tissues are activated by low-intensity ultrasound produce reactive oxygen species. However, clinical translation of SDT faces challenges, including limited efficiency resistance posed microenvironment. The emergence nanomedicine offers innovative strategies address these obstacles. This review discusses enhancing efficacy sonosensitizers, rational structural modifications, improved tumor-targeted enrichment, microenvironment remodeling, imaging-guided therapy. Additionally, SDT-based multimodal therapies, such as sono-chemotherapy, sono-immunotherapy, sono-photodynamic therapy, their potential applications breast treatment summarized. underlying mechanisms briefly outlined. Finally, this highlights current challenges prospects SDT, providing insights into future may improve outcomes cancer. Graphical abstract
Language: Английский
Citations
0
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
The complex tumor microenvironment (TME) affects reactive oxygen species (ROS)-based therapies; breaking the limitations of TME to enhance effectiveness sonodynamic therapy (SDT) is full great challenges. Herein, iron atomically dispersed nanoparticles (Fe-N-C) were first reported as sonosensitizers with highly efficient ROS generation by overcoming limitations. Its peroxidase and catalase-like activities catalyze H2O2 produce toxic ·OH in situ O2, respectively, then O2 molecules adsorbed at Fe active sites obviously lower energy barrier for formation. Meanwhile, its glutathione-oxidase-like activity can rapidly consume glutathione (GSH) induce cell apoptosis ferroptosis. Density functional theory calculation results elucidate possible mechanism generation: are activated receiving sonoelectrons generate ·O2-, which further reacts H2O OH-. Then OH- oxidized sonoholes form ·OH. Fe-N-C displays a superior specificity SDT.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123027 - 123027
Published: Dec. 15, 2024
Language: Английский
Citations
0