Noninvasively Real‐Time Monitoring In‐Vivo Immune Cell and Tumor Cell Interaction by NIR‐II Nanosensor

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Immunocytotherapy holds significant promise as a novel cancer treatment, but its effectiveness is often hindered by delayed responses, requiring evaluations every 2–3 weeks based on current diagnostic methods. Early assessment of immune cell‐tumor cell interactions could provide more timely insights into therapeutic efficacy, enabling adjustments to treatment plans. In this study, noninvasive nanosensor (C8R‐DSNP) for real‐time monitoring in vivo activities the second near‐infrared long‐wavelength (NIR‐II‐L) window (1500–1900 nm), which offers deep tissue transparency, reported. The C8R‐DSNP responds rapidly caspase‐8, key apoptotic signaling molecule generated during between natural killer (NK‐92) cells and tumor cells. Using ratiometric NIR‐II‐L fluorescence imaging, dynamic observations NK‐92 cells' engagement with mouse model are captured. These results demonstrate apoptosis that happens early 4.5 h after infusion. Additionally, vitro urine imaging confirmed initiation via cleaved fluorescent small molecules, while single‐cell tracking within blood vessels tumors further elucidated dynamics. This approach valuable optimizing immunocytotherapy strategies.

Language: Английский

The graphite-phase carbon nitride/silver nanoclusters nanocomposites ratiometric fluorescent probe for detection of glutathione and recognition of cancer cells

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113706 - 113706

Published: April 1, 2025

Language: Английский