Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance
Xu Guo,
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Haozhe Piao,
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Rui Sui
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et al.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(4)
Published: Feb. 1, 2025
ABSTRACT
Gliomas
are
the
most
ordinary
primary
virulent
brain
tumours
and
commonly
used
clinical
treatments
include
tumour
resection,
radiation
therapy
chemotherapy.
Although
significant
progress
has
been
made
in
recent
years
progression‐free
survival
(PFS)
overall
(OS)
for
patients
with
high‐grade
gliomas,
prognosis
remains
poor.
Chemoresistance
refers
to
phenomenon
of
decreased
sensitivity
cells
drugs,
resulting
reduced
or
ineffective
drug
efficacy,
is
an
important
cause
failure
Exosomes,
a
type
extracellular
vesicle,
secreted
by
cancer
various
stromal
microenvironment
(TME)
transfer
their
inclusions
cells,
increasing
chemoresistance.
Furthermore,
depletion
exosomes
reverses
certain
detrimental
effects
on
metabolism
restores
chemotherapeutic
agents.
Here,
we
summarised
correlation
between
resistance
agents
glioma
patients,
mechanisms
action
involved
value.
We
aimed
afford
new
thoughts
research,
diagnosis
intervention
chemoresistance
patients.
Language: Английский
Unlocking the Human Blood-brain barrier (BBB) Characteristics for the Development of Nano-Delivery Strategies for Central Nervous System Therapies
Cemile Gokce,
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Bağdagül Altun,
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Esen Kirit
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et al.
Journal of Drug Delivery Science and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106961 - 106961
Published: April 1, 2025
Language: Английский
Brain organoids-on-chip for neural diseases modeling: History, challenges and trends
Journal of Pharmaceutical Analysis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101323 - 101323
Published: April 1, 2025
Language: Английский
Targeted eradication of glioblastoma via venom decapeptide-conjugated dendrimers: Inducing nuclear translocation and autophagic cell death
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113780 - 113780
Published: April 1, 2025
Language: Английский
Bioprinting of GelMA-Based Hydrogels to Aid in Creation of Biomimetic 3D Models for Glioblastoma
Kaitlyn Ann Rose Schroyer,
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Klaus‐Peter Schmitz,
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Gunjeeta Raheja
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et al.
Micromachines,
Journal Year:
2025,
Volume and Issue:
16(6), P. 654 - 654
Published: May 29, 2025
Glioblastoma
(GBM,
isocitrate
dehydrogenase
wild-type)
is
the
most
common
primary
malignant
brain
tumor
in
adults
and
associated
with
a
severely
low
survival
rate.
Treatments
offer
mere
palliation
are
ineffective,
due,
part,
to
lack
of
understanding
intricate
mechanisms
underlying
disease,
including
contribution
microenvironment
(TME).
Current
GBM
models
continue
face
challenges
as
they
critical
components
properties
required.
To
address
this
limitation,
we
developed
innovative
practical
three-dimensional
(3D)
structural
mechanical
biomimicry
tunability.
These
allowed
for
more
accurate
emulation
extracellular
matrix
(ECM)
vasculature
characteristics
native
TME.
Additionally,
3D
bioprinting
was
utilized
integrate
these
complexities,
employing
hydrogel
composite
mimic
environment
that
known
contribute
cell
growth.
First,
examined
changes
physical
resulted
from
adjoining
hydrogels
at
diverse
concentrations
using
Fourier-Transform
Infrared
Spectroscopy
(FTIR),
compression
testing,
scanning
electron
microscopy
(SEM),
rheological
analysis,
degradation
analysis.
Subsequently,
refined
optimized
embedded
processes.
The
resulting
were
structurally
reliable
reproducible,
featuring
integrated
inner
channels
possessing
tunable
emulate
ECM.
Biocompatibility
testing
performed
via
live/dead
AlamarBlue
analyses
cells
(both
commercial
lines
patient-derived
lines)
encapsulated
constructs,
along
immunohistochemistry
staining
understand
how
ECM
altered
functions
cells.
observed
behavior
indicated
greater
functionality
softer
matrices,
while
incorporation
hyaluronic
acid
(HA)
into
gelatin
methacryloyl
(gelMA)
enhanced
its
findings
underscore
role
TME
components,
particularly
properties,
influencing
survival,
proliferation,
molecular
expression,
laying
groundwork
further
mechanistic
studies.
outcomes
validate
potential
leveraging
modeling,
providing
fully
controllable
explore
specific
pathways
therapeutic
targets
challenging
study
conventional
model
systems.
Language: Английский