A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

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ANTICANCER LIPID-BASED DRUG DELIVERY SYSTEMS: BASIC KNOWLEDGE AND RECENT APPLICATIONS

Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100054 - 100054

Published: Oct. 1, 2024

Language: Английский

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Liver cancer: Current status of preclinical research

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 34

Published: Jan. 1, 2025

Language: Английский

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Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can’t exert a therapeutic effect due to lack of targeting cells and entrapment in lysosomes upon administration. To address the challenges associated with delivery, delivery system was developed using zinc oxide nanoparticles (ZnO NPs) coated cancer cell membranes. ZnO been recognized as effective pH-responsive are widely used development drug systems pH-responsive. The NPs were combined chitosan encapsulate siRNA, allowing dissolution acidic subsequent release complexes. would also disrupt lysosomes, facilitating escape enhancing its gene silencing effect. nano-complexes (CS/ZnO@iRNA) unstable solution lacked specific cells. Thus, homologous membrane onto nanoparticles, which has shown be an strategy their stability capabilities. Moreover, not only dissolve enhance efficacy but elevate oxidative stress levels cells, leading induction cellular apoptosis. It demonstrated both in vitro vivo that could synergistically combine anti-tumor (siSurvivin) inhibit growth 4T1 tumor. Altogether, (CCM-CS/ZnO@siSurvivin) offers new while inhibiting growth.

Language: Английский

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A multimodal imaging nanobubble enhancing sonodynamic therapy by cell membrane disruption for effective anti-melanoma

Biomaterials, Journal Year: 2025, Volume and Issue: 324, P. 123450 - 123450

Published: May 31, 2025

Language: Английский

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