Biomaterials, Journal Year: 2025, Volume and Issue: 324, P. 123450 - 123450
Published: May 31, 2025
Language: Английский
Biomaterials, Journal Year: 2025, Volume and Issue: 324, P. 123450 - 123450
Published: May 31, 2025
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer
Language: Английский
Citations
2Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100054 - 100054
Published: Oct. 1, 2024
Language: Английский
Citations
4Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 34
Published: Jan. 1, 2025
Language: Английский
Citations
0Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Language: Английский
Citations
0Biomaterials, Journal Year: 2025, Volume and Issue: 324, P. 123450 - 123450
Published: May 31, 2025
Language: Английский
Citations
0