Progress in Organic Coatings, Journal Year: 2024, Volume and Issue: 200, P. 108980 - 108980
Published: Dec. 5, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101557 - 101557
Published: Feb. 5, 2025
Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.
Language: Английский
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0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: Feb. 18, 2025
Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.
Language: Английский
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0
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114275 - 114275
Published: March 1, 2025
Language: Английский
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ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Language: Английский
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0
Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 00(00)
Published: March 25, 2025
Hypertension represents a highly prevalent chronic condition and stands among the foremost contributors to premature mortality on global scale. Its etiopathogenesis is intricate multifaceted, being shaped by diverse array of elements such as age, genetic predisposition, activation neuroendocrine apparatus. Mounting evidence has shed light significant part that autoimmune responses play in hypertension ensuing damage end organs. Virtually all varieties immune cells, spanning both innate adaptive compartments, exhibit close correlation with progression hypertension. These cells infiltrate kidney vascular mesenchyme, subsequently discharging potent cytokines, reactive oxygen species, metalloproteinases. This cascade events can affect functionality local blood vessels potentially precipitate adverse structural functional alterations crucial organs like heart kidney. In recent times, management end-organ emerged pivotal scientific focus. A multitude researchers are actively engaged probing efficacious intervention regimens, which immunotherapy strategies hold considerable promise anticipation prospective avenue.
Language: Английский
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ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Language: Английский
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Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Chronic wound treatment poses a substantial challenge to healthcare systems. Certain herbal medicines have demonstrated clinical efficacy in promoting chronic healing, yet their therapeutic mechanisms at the molecular level remain elusive due complex composition and multifaceted nature. In this study, Ba-Hao ointment (BHO), sophisticated formulation with diverse ingredients, is selected as model precisely investigate its wound-healing mechanism. Network pharmacology analysis docking simulations reveal that BHO specifically interacts key proteins, including vascular endothelial growth factor A (VEGFA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), suggesting ability modulate critical biological pathways involved inflammation tissue regeneration. Experimental validation further demonstrates significantly promotes cell proliferation, suppresses bacterial infection, enhances expression of essential factors such epidermal (EGF) VEGFA normal human dermal fibroblasts (NHDF), all which are vital for effective healing. vivo studies confirm accelerates closure, reduces inflammation, development well-organized granulation via activation PI3K-Akt signaling pathway. This study interesting since it unveils BHO's role furthering medicine insights.
Language: Английский
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Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162627 - 162627
Published: April 1, 2025
Language: Английский
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Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137696 - 137696
Published: April 1, 2025
Language: Английский
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0