Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

ABSTRACT Alzheimer's disease (AD) is one of the most prevalent forms neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) recognized to play an essential role in pathophysiology AD. The Aβ species are known exist various forms, including soluble monomers, oligomers, and insoluble aggregates. Despite extensive efforts regulate aggregation, no successful medications have been developed date. Among strategies for AD treatment, phototherapy, photodynamic therapy (PDT), photothermal (PTT), photopharmacology, photobiomodulation (PBM) attracted increased attention because spatiotemporal controllability. Representative examples PDT, PTT, PBM discussed terms inhibitory mechanism, unique properties materials, design phototherapy modulators. major challenges against addressed promising prospects proposed. It concluded that noninvasive light‐assisted approaches will become a strategy intensifying modulation aggregation or promoting clearance thus facilitating treatment.

Language: Английский

Cerium-doped carbon dots as dual-target agents against Alzheimer's β-amyloid fibrillogenesis and reactive oxygen species

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114655 - 114655

Published: March 1, 2025

Language: Английский

Aβ aggregation inhibition via peptide-conjugated gold nanoclusters: Mechanistic insights and therapeutic potential

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 114032 - 114032

Published: May 1, 2025

Language: Английский